Mary Philip
Nashville
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Articles by Mary Philip
Duration of antibiotic treatment for infective endocarditis: should we move towards tailored therapy?
The POET II trial reports that stopping antibiotic treatment in patients with endocarditis once they are clinically stable shortens the treatment duration without excess risk of death or surgery, but triples the rates of relapse of endocarditis or bacteraemia. This response-guided strategy marks a genuine shift beyond the oral-antibiotic-switch paradigm from the POET trial, and the safety of the approach will depend on rigorous patient selection and close multidisciplinary follow-up.
New insights into progenitor exhausted T cell populations
In this Viewpoint, eight experts from the field of T cell exhaustion discuss current understanding of the self-renewing population of PD1+TCF1+TOX+ precursor and/or progenitor exhausted CD8+ T cells and controversies related to their development and function.
Immune cells become exhausted within hours of encountering tumors
A key function of our immune system is to detect and eliminate foreign pathogens such as bacteria and viruses. Immune cells like T cells do this by distinguishing between different types of proteins within cells, which allows them to detect the presence of infection or disease. A type of T cell called cytotoxic T cells can recognize the mutated proteins on cancer cells and should therefore be able to kill them. However, in most patients, cancer cells grow unchecked despite the presence of T cells.
Cancer exhausts immune cells - understanding why could help strengthen their response
A key function of our immune system is to detect and eliminate foreign pathogens such as bacteria and viruses. Immune cells like T cells do this by distinguishing between different types of proteins within cells, which allows them to detect the presence of infection or disease. A type of T cell called cytotoxic T cells can recognise the mutated proteins on cancer cells and should therefore be able to kill them. However, in most patients, cancer cells grow unchecked despite the presence of T cells.
Immune cells are exhausted within hours of encountering tumors - new research
(THE CONVERSATION) A key function of our immune system is to detect and eliminate foreign pathogens such as bacteria and viruses. Immune cells like T cells do this by distinguishing between different types of proteins within cells, which allows them to detect the presence of infection or disease. A type of T cell called cytotoxic T cells can recognize the mutated proteins on cancer cells and should therefore be able to kill them.
Immune cells that fight cancer become exhausted within hours of first encountering tumors, new research shows
A key function of our immune system is to detect and eliminate foreign pathogens such as bacteria and viruses. Immune cells like T cells do this by distinguishing between different types of proteins within cells, which allows them to detect the presence of infection or disease. A type of T cell called cytotoxic T cells can recognize the mutated proteins on cancer cells and should therefore be able to kill them. However, in most patients, cancer cells grow unchecked despite the presence of T cells.
T cells burn out just a few hours after encountering cancer tumors
A key function of our immune system is to detect and eliminate foreign pathogens such as bacteria and viruses. Immune cells like T cells do this by distinguishing between different types of proteins within cells, which allows them to detect the presence of infection or disease. A type of T cell called cytotoxic T cells can recognize the mutated proteins on cancer cells and should therefore be able to kill them. However, in most patients, cancer cells grow unchecked despite the presence of T cells.
Immune cells that fight cancer become exhausted within hours of first encountering tumors
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)
Immune cells that fight cancer become exhausted within hours of first encountering tumors
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.)
Immune cells that fight cancer become exhausted within hours of first encountering tumors - new research Original
A key function of our immune system is to detect and eliminate foreign pathogens such as bacteria and viruses. Immune cells like T cells do this by distinguishing between different types of proteins within cells, which allows them to detect the presence of infection or disease. A type of T cell called cytotoxic T cells can recognize the mutated proteins on cancer cells and should therefore be able to kill them. However, in most patients, cancer cells grow unchecked despite the presence of T cells.
Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research | Flipboard
7 hours ago What's four-legged, furry, and often serves up a quick little mood boost? That's right, a dog. It turns out even short, friendly interactions with canines can be good for our health. I started pondering the power of dogs during one of my daily strolls around my neighborhood. Almost invariably, I'll …
Immune cells that fight cancer become exhausted within hours of first encountering tumors - new research
Thu Aug 3 Written by Mary Philip, Assistant Professor of Medicine and Pathology, Vanderbilt University A key function of our immune system is to detect and eliminate foreign pathogens such as bacteria and viruses. Immune cells like T cells[1] do this by distinguishing between different types of proteins within cells, which allows them to detect the presence of infection or disease.
Immune cells that fight cancer become exhausted within hours of first encountering tumors - new research
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) Mary Philip, Vanderbilt University and Michael Rudloff, Vanderbilt University kAmW%wt r~}'t#$p%x~}X p <6J 7F?4E:@? @7 @FC :>>F?6 DJDE6> :D E@ 56E64E 2?5 6=:>:?2E6 7@C6:8? A2E9@86?D DF49 2D 324E6C:2 2?5 G:CFD6D] x>>F?6 46==D =:<6 k2 9C67lQ9EEADi^^E964@?G6CD2E:@?]4@>^4@C@?2G:CFD\3\46==D\2?5\E\46==D\6IA=2:?65\`c`gggQm% 46==Dk^2m 5@ E9:D 3J 5:DE:?8F:D9:?8 36EH66?
Immune cells that fight cancer become exhausted within hours of first encountering tumors - new research
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) Mary Philip, Vanderbilt University and Michael Rudloff, Vanderbilt University kAmW%wt r~}'t#$p%x~}X p <6J 7F?4E:@? @7 @FC :>>F?6 DJDE6> :D E@ 56E64E 2?5 6=:>:?2E6 7@C6:8? A2E9@86?D DF49 2D 324E6C:2 2?5 G:CFD6D] x>>F?6 46==D =:<6 k2 9C67lQ9EEADi^^E964@?G6CD2E:@?]4@>^4@C@?2G:CFD\3\46==D\2?5\E\46==D\6IA=2:?65\`c`gggQm% 46==Dk^2m 5@ E9:D 3J 5:DE:?8F:D9:?8 36EH66?
Immune cells that fight cancer become exhausted within hours of first encountering tumors - new research
(The Conversation is an independent and nonprofit source of news, analysis and commentary from academic experts.) Mary Philip, Vanderbilt University and Michael Rudloff, Vanderbilt University kAmW%wt r~}'t#$p%x~}X p <6J 7F?4E:@? @7 @FC :>>F?6 DJDE6> :D E@ 56E64E 2?5 6=:>:?2E6 7@C6:8? A2E9@86?D DF49 2D 324E6C:2 2?5 G:CFD6D] x>>F?6 46==D =:<6 k2 9C67lQ9EEADi^^E964@?G6CD2E:@?]4@>^4@C@?2G:CFD\3\46==D\2?5\E\46==D\6IA=2:?65\`c`gggQm% 46==Dk^2m 5@ E9:D 3J 5:DE:?8F:D9:?8 36EH66?
Impact of cardiac surgery on left-sided infective endocarditis with intermediate-length vegetations
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CD8+ T cell differentiation and dysfunction in cancer
1. De Plaen, E. et al. Immunogenic (tum-) variants of mouse tumor P815: cloning of the gene of tum- antigen P91A and identification of the tum- mutation. Proc. Natl Acad. Sci. USA 85, 2274–2278 (1988). This is the first study to identify a somatic mutation in a mouse cancer cell line variant creating a cytolytic T lymphocyte-recognized epitope using a cloning-based approach. PubMed PubMed Central Article Google Scholar 2. Mandelboim, O. et al.
CD226 Throttles up CD8+ T Cell Antitumor Activity
Summary In this issue of Immunity, Weulersse et al. and Braun et al. explain how CD226 expression loss on CD8 + T cells impairs TCR-driven activation, and thereby anti-tumor effector responses, tantamount to taking the CD8 + T cell’s foot off the gas pedal. To read this article in full you will need to make a payment Purchase one-time access Read-It-Now Purchase access to all full-text HTML articles for 6 or 36 hr at a low cost. Click here to explore this opportunity.
Comparison Between ESC and Duke Criteria for the Diagnosis of Prosthetic Valve Infective Endocarditis:
Abstract Objectives The primary objective was to assess the value of the European Society of Cardiology (ESC) criteria, including 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG-PET/CT) in prosthetic valve infective endocarditis (PVE).
Defining ‘T cell exhaustion’ - Nature Reviews Immunology
Abstract ‘T cell exhaustion’ is a broad term that has been used to describe the response of T cells to chronic antigen stimulation, first in the setting of chronic viral infection but more recently in response to tumours. Understanding the features of and pathways to exhaustion has crucial implications for the success of checkpoint blockade and adoptive T cell transfer therapies.
Prognostic Value of 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Infective Endocarditis
Journal of the American College of Cardiology Original Investigation Sovannarith San, Eleonore Ravis, Laetitia Tessonier, Mary Philip, Serge Cammilleri, Flora Lavagna, Giulia Norscini, Florent Arregle, Hélène Martel, Leopold Oliver, Olivier Torras, Sébastien Renard, Pierre Ambrosi, Laurence Camoin, Anne Claire Casalta, Sandrine Hubert, Jean Paul Casalta, Frédérique Gouriet, Alberto Riberi, Jean-François Avierinos, Hubert Lepidi, Frederic Collart, Didier Raoult, Michel Drancourt and Gilbert...
Microenvironmental Metabolism Regulates Antitumor Immunity
Reviews Verra M. Ngwa, Deanna N. Edwards, Mary Philip and Jin Chen DOI: 10.1158/0008-5472.CAN-19-0617 Published August 2019 This article requires a subscription to view the full text. You may purchase access to this article or login to access your subscription using the links below. Abstract Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors.
Microenvironmental Metabolism Regulates Antitumor Immunity
Review Verra M. Ngwa, Deanna N. Edwards, Mary Philip and Jin Chen DOI: 10.1158/0008-5472.CAN-19-0617 Abstract Metabolic reprogramming of cancer cells and the tumor microenvironment are emerging as key factors governing tumor growth, metastasis, and response to therapies including immune checkpoint inhibitors. It has been recognized that rapidly proliferating cancer cells, tumor-infiltrating lymphocytes, and vascular endothelial cells compete for oxygen and nutrients.
Friday Night ‘Special’
Illustrated by David Beling By Mary Anne Philip Welcome to Lanka who has lost her good reason, Where people must fight in and out of their season. Each one for themselves and not one for the other, Now whom can you turn to and call your own brother? Each hour brings a new dread, for we cannot tell, What deeds will come under the sorcerer’s spell. The days of the week do go by in a flash, And Friday once more brings in some new trash.
Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis
Dynamic Molecular Program Associated with the Differentiation and Fate Commitment of Tumor Antigen-Specific T Cells to the Dysfunctional State Tumor-Specific CD8+ T Cells Isolated from Pre- and Early Malignant Lesions Exhibit the Molecular Hallmarks of CD8+ T Cells from Late-Stage Human and Mouse Tumors Tumor-Specific CD8+ T Cells in Pre-malignant Lesions Reveal Conserved and Distinct Molecular Characteristics of Exhausted and Self-Tolerant CD8+ T Cells Presence and Persistence of Antigen...
Deciphering the epigenetic programming underlying CD8 T cell dysfunction in solid tumors
Tumor-specific CD8 T cells in progressive solid tumors express inhibitory receptors and fail to proliferate and produce effector cytokines. Using a mouse model (ASTxCre-ERT2) in which tamoxifen (TAM) treatment induces an oncogenic driver neoantigen, SV40 large T antigen (Tag) in hepatocytes, we previously showed that tumor-specific CD8 T cells (TCR ) become unresponsive quite early during the pre-/early malignant phase.
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