Matt Kaeberlein on Muck Rack

Matt Kaeberlein

As seen in: Nature, The Hill, Science Magazine, The Lancet, JoVE- Journal of Visualized Experiments, The Journal of Biological Chemistry, Tiger Sniff
Husband, father, scientist, athlete (sort of), CEO, recovering academic. Passionate about helping people and companion animals live longer, healthier lives.
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Articles

全球首例人体内细胞重编程抗衰老疗法开始临床试验，治疗青光眼

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By David Sinclair, Matt Kaeberlein
| Tiger Sniff
一种声称能让人体细胞“返老还童”的疗法，不久前刚完成了首例患者给药。这也是第一次有人尝试使用这种技术，在人体内直接重编程细胞，诱导衰老细胞恢复年轻状态。 当地时间6月9日，美国生物科技公司Life Biosciences宣布，首次接受治疗的是青光眼患者，将评估“ER-100”疗法的安全性和耐受性，包含受试者视觉功能恢复情况。 ER-100是一种极具想象力的创新基因疗法，它通过激活3个基因，从而改造衰老细胞，让它们恢复年轻时的功能。研究人员还设计了一个开关——多西环素。如果停止服用这种抗生素，“激活年轻的程序”就会关闭。 “如果能安全地应用于人体，基因重编程技术将具有巨大的潜力。”华盛顿大学健康老龄化与长寿研究所Matt Kaeberlein教授对《自然》表示。 但他同样担忧，这项技术仍处于非常早期的阶段，出现灾难性副作用的可能性很高。 “返老还童针” Life Biosciences成立于2017年，由哈佛医学院遗传学系教授、抗衰老专家David Sinclair联合创立。 根据公司官网，Life...
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An anti-depressant drug vortioxetine suppresses malignant glioblastoma cell growth.

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By Matt Kaeberlein, Mayur Nimbadas Devare
| biorxiv.org
Abstract Glioblastoma (GBM) stands as the predominant primary malignant brain tumor in adults, characterized by an exceedingly grim prognosis. Urgent efforts are essential to pioneer effective therapeutics capable of addressing both the intrinsic and acquired resistance exhibited by GBM towards existing treatments. This study employs a drug repurposing strategy to explore the anti-cancer potential of vortioxetine in malignant U251 and T98G glioblastoma cells.
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ExplaiNAble BioLogical Age (ENABL Age): an artificial intelligence framework for interpretable biological age

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By Wei Qiu, Hugh Chen, Matt Kaeberlein, Su-In Lee
| The Lancet Verified
Research in context Evidence before this study Biological age has an important role in understanding the mechanisms underlying ageing. We searched PubMed with the terms “biological age” for original articles published in all languages from database inception to June 22, 2022. Most previous studies focused on the first generation of biological age clocks that were designed to predict chronological age.
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