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Articles by Matthew Block
Five-year survival with neoadjuvant therapy in melanoma: updated pooled analysis from the International Neoadjuvant Melanoma Consortium (INMC)
Abstract Neoadjuvant immune checkpoint inhibitors (ICIs) are standard of care for resectable stage IIIB–D melanoma, but knowledge gaps remain regarding optimal treatment type, long-term survival, postsurgical management and clinical, histopathological or molecular subgroups.
Latvian Lutherans elect a new archbishop
On June 7, the Evangelical Lutheran Church of Latvia (Latvijas Evaņģēliski luteriskā baznīca – LELB) elected Bishop Rinalds Grants to serve as its new archbishop. The election took place during the LELB’s 30th Synod, which was held June 6-7 in Riga. At the time of his election, Bishop Grants was serving as Auxiliary Bishop of Riga.
Neoadjuvant cobimetinib and atezolizumab with or without vemurafenib for stage III melanoma: outcomes and the impact of the microbiome from the NeoACTIVATE trial
Discussion Here, we show that a short course of the neoadjuvant combination of targeted therapy and immune checkpoint blockade leads to favorable recurrence-free and DMFS in a substantial portion of patients with high-risk stage III melanoma. To the best of our knowledge, this is the first neoadjuvant study to test the combination of a targeted agent plus immune checkpoint blockade in patients with BRAFwt melanoma.
Plasma exchange and radiation resensitize immunotherapy-refractory melanoma: a phase I trial - Nature Communications
Abstract Immune checkpoint inhibitors (ICI) are effective for advanced melanoma. However, most develop ICI resistance. Tumor-derived soluble PD-L1 (sPD-L1) and other immunosuppressive factors drive resistance. We hypothesized that therapeutic plasma exchange (TPE) may remove sPD-L1 from circulation and overcome ICI resistance. Patients with metastatic ICI-resistant melanoma and elevated sPD-L1 received radiotherapy to a minority of metastatic lesions, TPE, and ICI re-challenge.
The oncolytic adenovirus TILT-123 with pembrolizumab in platinum resistant or refractory ovarian cancer: the phase 1a PROTA trial - Nature Communications
Abstract Immune checkpoint inhibitors have demonstrated modest efficacy as a monotherapy in ovarian cancer. Originally developed to improve efficacy of T-cell therapies such as immune checkpoint inhibitors and adoptive cell transfer, TILT-123 (Ad5/3-E2F-D24-hTNFα-IRES-hIL-2) is a serotype chimeric oncolytic adenovirus encoding tumor necrosis factor alpha and interleukin-2.
Conflicts of Interest in an Evolving Landscape: Potential Areas of SEC Examination Risk for GP‑Led Secondary Transactions
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PG545 sensitizes ovarian cancer cells to PARP inhibitors through modulation of RAD51-DEK interaction - Oncogene
Reagents PG545 was provided by Zucero Therapeutics (Brisbane, Australia). Olaparib and niraparib were purchased from LC Laboratories (Woburn, MA) and Chemietek (Indianapolis, IN), respectively. Rucaparib was kindly provided by Clovis Oncology (Boulder, CO). The concentrations used for all drugs in vitro and in vivo were therapeutically achievable [10, 34]. Other reagents and antibodies are listed in Table S1. Cell culture and drug sensitivity Cell lines used in this study are listed in Table S2.
3. Results A total of 287 patients with melanoma ITM from 21 institutions in eight different countries treated with immunotherapy were included in the analysis ( Supplementary Table 1 ). Overall, 161 patients (56%) were male, and the median age at the start of ICI was 69 years (IQR 59–78). The median time from melanoma diagnosis to the first in-transit recurrence was 13 months (IQR 5–30).
Ongoing salary freeze harming prosecutor retention
Law Rule of law Not addressing it will result more unfilled positions, and less justice for rural Albertans. BY Matthew Block 20 Feb 2020 As one of the few departments to see an increase in the 2019 provincial budget, the Alberta Crown Prosecution Service will have funding for 50 new prosecutors over the next three years. This is a needed investment in a justice system that has gradually slipped into critical underfunding.
No Live Concerts, No Problem!
While we are all social distancing, we need to be entertained so enjoy these concerts: Note : These are raw live streaming videos from artists, that can include graphic language, viewer discretion is advised.
Rapid generation of sustainable HER2-specific T cell immunity in HER2 breast cancer patients using a degenerate HLA class II epitope vaccine
Research Article Keith L Knutson, Matthew S. Block, Nadine Norton, Courtney L. Erskine, Timothy J Hobday, Allan B. Dietz, Douglas Padley, Michael P. Gustafson, Danell Puglisi-Knutson, Toni Kay Mangskau, Saranya Chumsri, Amylou C. Dueck, Lavakumar Karyampudi, Glynn Wilson and Amy C. Degnim DOI: 10.1158/1078-0432.CCR-19-2123 Abstract Purpose: HER2+ breast cancer patients benefit from trastuzumab-containing regimens with improved survival.
New Job Opportunities In Amarillo With No Limits No Excuses
No Limits No Excuses (NLNE) welcomed 14 new partners to their organization in hopes in continuing to build the economy and job opportunities in Amarillo. While their goal is to build and train the future workforce, NLNE strives to have students find jobs locally and stay local to help build the economy here in Amarillo. There are tons of jobs currently available in Amarillo due to the resources already available.
Perryton ISD To Open A New Daycare
The Ranger Roundup Learning Center , a joint project of Perryton Independent School District and Ochiltree General Hospital, will open its doors on a limited basis on Monday, Aug. 19. During this time, students will be limited to children of Perryton ISD employees who pre-registered. Licensing restrictions limit the number of students based on staff size. Ranger Roundup is still hiring and training staff.
Donate School Supplies To Help Children Start The School Year Right
Donate School Supplies To Help Children Start The School Year Right
Braids And Fades Event Helps Students Start School Year With Fresh Look
Braids And Fades Event Helps Students Start School Year With Fresh Look
Two Fritch Residence Dead In Hobbs Crash
Two Fritch residence and one other individual where part of a vehicle collision near Hobbs, New Mexico. On July 24th at 5:45 a.m. the driver of a semi, 60-year-old James Law of Hobbs, failed to yield on State Road 529, approaching intersection U.S. 62 and 180. 47-year-old Brady Steele of Dublin, Texas, was the driver of the pickup that was struck by the semi’s trailer. 25-year-old Dakota Lujin, 21-year-old Nigel Key of Fritch, and Brady Steele where all pronounced dead at the scene.
Amarillo College Matney Mass Media Honors KGNC's Patrick Clark
The Amarillo College Matney Mass Media Advisory Board’s 2019 meeting will be August 13 at 11 a.m. in the Panhandle PBS studio. The meeting takes place once a year to seek guidance from industry professionals regarding the curriculum and to obtain feedback regarding how to best prepare students for media related careers.
P.E.T.S Clinic Is One Step Closer To Being Open To The Public
The P.E.T.S clinic is not officially open to the public until August 5, but they say with appointments filling up quickly, they are ready to hit the ground. The clinic has some renovations to be completed before the grand opening but they are already working with other animal advocates by performing surgeries. Executive Director Dacia Anderson said they have performed 40 surgeries this week and they will do 40 more surgeries next week.
New Ronald McDonald House will Be Build
Ronald McDonald House-EM The Ronald McDonald House Charities of Amarillo will soon be torn down but a new one will be going up. The Ronald McDonald House is a home away from home for families who come to Amarillo for their kids to receive medical care from all over the country. The 12 room house will be torn down in less than a month though the new house will be two stories with 14 rooms and is expected to have new appliances.
Yellow City Sounds Goes Western
Western music icon Michael Martin Murphey will be headlining the next Yellow City Sounds concert. The show is a celebration of Murpheys career as an American songwriter with over 50 years of influence in the Texas music scene, blurring the lines between pop, country, rock and jazz. PBS Producer, Chip Chandler, https://www.kgncnewsnow.com/wp-content/uploads/2019/07/7-15-YCSL-CHIP-CHANDLER-FULL.wav The concert will begin at 7 P.M., August 5, at the Panhandle PBS studio on 2408 S.
Canyon ISD Moves Forward With New Schools
Canyon ISD Moves Forward With New Schools In 2018, Canyon ISD voted on a bond election to help construct a new high school and two elementary schools. The plans are still in the design phase and will take some time to complete. However the elementary schools are scheduled to be completed by August of 2021 and the high school is set to be finished August of 2022. -KG
Lake Meredith's "Movies at the Lake" Summer Schedule
Lake Meredith is pleased to announce “Movies at the Lake” Summer Movie Series. Here are the following dates and times: Saturday, June 15th 9:15 PM- Aquaman Wednesday July 3rd 10:15 PM- The Wizard of Oz Saturday August 3rd 9:00 PM- Captain Marvel Movies will be shown at the Lake Meredith Fritch Fortress Amphitheater, admission is free and concessions will be available on site.
Amarillo Native Serves Aboard Navy Warship
Petty Officer 3rd Class Tyler Lamberth, an Amarillo native carries on a proud family tradition of serving in the Navy. Lamberth, a 2016 graduate of Tascosa High School serves aboard one of the Navy’s most advanced amphibious ships at Fleet Activities Sasebo in Japan.
Local Law Enforcement Teams Up
Drinking and driving continues to be a major problem in our area. Local law enforcement is attacking the problem head on. Sergeant Cindy Barkley with the Texas Department of Public Safety.
Amarillo Public Library Launches New Program With The Amarillo Zoo
The Amarillo Public Library is offering some fun in the sun this summer for families. The APL is joining with the Amarillo Zoo to launch a new Family Zoo Pass Program. This program will allow families to check out a pass to the zoo at the library just like they would check out a book. One pass will be available for check out at each of the library’s five locations. The pass gives one family—two adults and up to six children—a one-time free visit to the Zoo.
Homeless Campaign to Announce $300,000 in Grants
The Interfaith Campaign for the Homeless will be at the Neely Conference Center at 10:00 AM on May 30 with the announcement of $300,000 in grants. Interfaith, run with the help of over 50 volunteers, helps raise and distribute funds to support multiple programs to keep men, women and children off the street. Thanks to the Katherine E. Brandy Fund, these grants will be shared between 14 nonprofit organizations across Amarillo. The announcement will be made at the Amarillo Area Foundation at 801 S.
High Plains Food Bank Let Provide A Summertime Meal
Tina Brohlin Kids are eating free all summer long thanks to High Plains Food Bank. Kids Café, a Feeding America Program run by the HPFB is providing free weekday lunches at 8 places starting June 3rd through August 2nd.
News Talk Sports 710AM & 97.5FM
A vacant warehouse in the 200 block of South Pierce Street caught fire on Wednesday night. At 9:53pm the Amarillo Fire Department arrived at the scene and requested assistance to help contain the blaze that raised a second level alarm. Eight units of the AFD were called to assist and where able to put out the fire. Officials reported that the warehouse was vacant, and there was evidence of transient people living around the building where the fire was said to have started.
Amarillo College Shares No Excuses Initiative
Amarillo College is beginning to see the benefits of the No Excuses Poverty Initiative. With a consistent increase in graduations following the addition of new programs to the AC system. Over 150 reps from 60 different facilities of higher education have come to Amarillo to see what makes AC tick.
Nine People Arrested For Failing To Register As Sex Offenders
Nine people were arrested this month for failing to register sex offenders. From May 13th through May 17th, a sex offender compliance check was conducted by the Amarillo Police Department Special Victims Unit Detectives, United States Marshal Service and Texas Department of Public Safety. Officials checked a total of 662 offenders in the Amarillo area to make sure they were in compliance with their registration requirements. Nine were found to be out of compliance and arrested.
AISD School Board Sets Regular Meeting
A regular meeting of the Board of Trustees of the Amarillo Independent School District will be held on May 21st. Agenda items to be discussed include recognizing trustees going off the board, administering the oath of office to declared winners in the May 4th election. Consider a request from the NAACP to change the name of Lee Elementary School, as well as consider a board resignation from Trustee John Ben Blanchard.
Amarillo Police Crack Down On Alcohol Sales to Minors
The Amarillo Police Department Detective Division conducted an operation to catch convenience store workers who have reportedly been selling alcohol to minors. During these operations a minor was able to buy alcohol from two different locations resulting in the arrests of two individuals. Tam Minh Trinh, 49, and Richie Tommy Inthavong Vang, 17, have both been booked and placed in the Potter County Detention Center. The APD Detective Division will not stop the crack-down on alcohol sales to minors.
APD And DPS Team Up To Enforce Seat Belt And Child Safety Seat Laws
The Amarillo Police Department is participating in the national Click It or Ticket campaign from Monday, May 20th through Sunday June 2nd. The Texas Department of Transportation gave a grant to the APD to fund extra officers to patrol, concentrating on seat belt and child restraint violations. Texas law requires that every person in a vehicle be secured by a safety belt.
Playa Event Rescheduled Due To Recent Rainfall
The Panhandle Chapter of the Texas Master Naturalists has rescheduled an upcoming event. A Playa Field Day event is rescheduled for Tuesday, May 21st starting at 9:30 a.m. in the Courtroom at Abernathy City Hall, 811 Avenue D due to recent heavy rainfall. The day will being with two presentations covering playa ecosystems, best management practices and playa restoration.
Memorial Run/Walk For The Fallen To Honor Chief Petty Officer
Chief Petty Officer Jack R. Barnes A chance to honor those who gave all. The Chief Petty Officer Jack R. Barnes Memorial Run/Walk for the Fallen will be held Monday, May 17th at Stephen F. Austin Park 2400 Crockett Street. The 5K Memorial Run will start at 8 am. The 1 Mile Walk for the Fallen will start at 9:30 am. Lunch, snacks and prizes will be available after the Mile Walk. You can register for this event online at http://getmeregistered.com/RunfortheFallen or on race day at 7 am at the park.
National Pet Adoption Weekend Hosted by PetSmart, Amarillo SPCA
PetSmart National Charities and the Amarillo SPCA are hosting the National Pet Adoption Weekend. This event allows the public to adopt some furry friends for a special price of $85. This adoption fee includes sterilization, rabies vaccinators, micro-chipping and up-to-date shots.
USA Cycling Hosts Championship
USA Cycling is coming to Amarillo for their Marathon Mountain Bike National Championship. The event will be held Saturday, May 11th starting at 10 am. An award ceremony will be held at the Pioneer Amphitheater at the end of the race.
Yellow City Comic Convention
Yellow City Comic Convention is back! It will be held at the Amarillo Civic Center on Friday, May 10th from 5 p.m. – 10 p.m., on Saturday, May 11th from 10 a.m. – 10 p.m. and on Sunday, May 12th from 11 a.m. – 6 p.m. This event will include appearances from several celebrity guests. Travis Tidmore with the Board of Directors of YC3 tells more about the guests. https://www.kgncnewsnow.com/wp-content/uploads/2019/05/0509-YC3-SHORT.mp3 To learn more about YC3, visit YELLOWCITYCON.COM.
Second San Jacinto Neighborhood Plan Meeting
The second San Jacinto Neighborhood Plan meeting will be held Tuesday, May 14th at 6 p.m. – 7:30 p.m. at the Rehrer Center at San Jacinto Christian Academy. This meeting is open to the public and a discussion will be held over the vision and guiding principles of the San Jacinto neighborhood for improvement. To learn more about the plan, please visit Amarillo.gov/sanjacintoplan For more information, visit our website KGNCNEWSNOW.COM
Muttfest 2019 To Be Held At Memorial Park
Muttfest is back! This annual event hosted by the Amarillo Society for the Prevention of Cruelty to Animals will be held at Memorial Park, Sunday, May 19th from noon-5 pm. This event is free and open to the public and will include many activities, such as pet contests, the Skyhoundz Frisbee championship, a silent auction, and a 50/50 cash drawing raffle. Pet-related vendor booths will be available and Lone Star Veterinary Services will be offering low-cost vaccinations.
City Transit Will Continue To Run Despite Weather, Delays Expected
Amarillo City Transit will continue to run regularly scheduled service hours for Tuesday, May 7. However, due to severe weather, end-of-day service operations may be impacted, causing delays. For more information on delays, please contact Amarillo City Transit at 806-378-3095.
Salvation Army Hosts Luncheon To Put A Face On The Homeless Crisis
The Salvation Army’s Lunch with The Homeless Day is back! For $5, members of the community can share a meal with someone without a home. Stephanie Pena, Public Relations/Donor Development Director with the Salvation Army talks about the importance of the event.
Elections Update For Amarillo Mayor, City Council, AISD Board, & AC Bond
The public has spoken. The mayor and current council members have overwhelmingly received a vote of confidence. Mayor Ginger Nelson easily defeated Claudette Smith and Kip Billips. In Place 1, Elaine Hays was given another two years, as well as Freda Powell in Place 2. In Place 3, Dr. Eddie Sauer defeated Tom Warren and Brad Torch. In Place 4, Howard Smith was the people’s choice. There will be three new members on the Amarillo Independent School District Board of Trustees.
The Panhandle Auto Burglary and Theft Unit Finds Stolen Vehicles
The Panhandle Auto Burglary and Theft Unit recovered a trailer and ATV stolen from in front of a local business along I-27. The property was located at a home in the 3700 block of Gamma Lane in Randall County. The PABTU recovered the property as well as a stolen RV. This incident is still under investigation.
Mission Amarillo’s Fam Fest
Join Mission Amarillo at their Fam Fest fundraising event. Live music, food trucks, and carnival games will be available at Sam Houston Park on Saturday, May 4th, from 11:00 a.m. to 2:00 p.m. Admission is free, but carnival games cost $1 each, or you can buy a wristband for $10, allowing unlimited play. We spoke with the Executive Director of Mission Amarillo, Jeff Parsons.
Texas Tech University Health Sciences Center Name Pharmacy School After Jerry Hodge
The Texas Tech University Health Sciences Center has named their pharmacy school after Amarillo businessman and philanthropist Jerry Hodge. In a press conference on Thursday, April 25th at 3:00 p.m., The TTU System Chancellor and TTUHSC President Tedd Mitchell officially announced the naming of TTUHSC Jerry H. Hodge School of Pharmacy. We spoke with Dr. Mitchell on the importance of naming the pharmacy school after Jerry Hodge.
City Of Amarillo Utility Billing Resumes Normal Practices
The City of Amarillo has finished transitioning to a new utility billing system. Beginning in May 2019, the Utility Billing Department will resume normal billing practices. For information regarding billing practices, take a look at the back of your utility bill. They can be paid online at billing.amarillo.gov, or by phone at (806) 576-1932. If you would like to pay in person, go to the Amarillo City Hall at 601 South Buchanan. Hours are from 8:00 a.m. to 5:00 p.m., Monday through Friday.
AISD Responds To Complaint
The Superintendent of the Amarillo Independent School District, Doug Loomis has issued an official response to Dr. Marc Henson’s complaint regarding Coach Kori Clements’ resignation. Dr. Henson’s complaint was filed to the Texas Education Agency in March. The TEA denied jurisdiction and said that the allegations should be filed within the district.
FogelEarth Festival At Wildcat Bluff
The Fogel-Eurth Festival will take place at the Wildcat Bluff Nature Center in honor of Earth Day! Doors open at 10:00 a.m. and admission is free. There will be many activities for kids, including a telescope for kids to look at sunspots.
Bob Wills Day 2019
Bob Wills Day is being held in Turkey, Texas from Thursday, April 25th through Saturday, April 27th. Thursday will kick off the event with the annual Bob Wills Dances and an all-star salute to the legends from 7:00 to 11:00 p.m. On Friday, the dance ticket will get you in for both Jake Hooker and the Outsiders and Friends of the Texas Playboys. Dancing will go down from 5:30 p.m. to midnight. Saturday brings back Jody Nix and the Texas Cowboys for an evening of dance.
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