World Sickle Cell Day lands on Juneteenth each year, a calendar coincidence for a genetic blood disorder that mostly affects people of African ancestry. More specifically, however, sickle cell disease is shaped by evolution in malaria-endemic regions of the world. And perhaps as triumphantly, it is entering an era of potential cures involving bone marrow transplants and newly FDA-approved gene therapies. The problem, as always, is cost and accessibility.