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A pilot translational study of neoadjuvant fulvestrant plus abemaciclib in women with advanced low-grade serous carcinoma

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By Lauren Cobb, Yibo Dai, Max Ayala, Nejla Ozirmak Lermi, Sharia Hernandez, Joseph Davis Verified, SangHoon Lee, Richard Hajek, Joseph Celestino, Jinsong Liu, Linghua Wang, Cara Haymaker, Ken Chen, Mei Jiang, Wei Lu, Minghao Dang, Sara Hagen Hull, David Vining, Bryan M. Fellman, Ying Yuan, Anil K Sood, Shannon N. Westin, Jolyn S. Taylor, Aaron Shafer, Nicole Fleming, Karen H. Lu, David M. Gershenson, Amir A Jazaeri, Barrett Craig Lawson, Beatriz Sanchez-Espiridion, Michael Bevers
| Nature Verified
Abstract Low-grade serous carcinoma of the ovary (LGSOC) is relatively resistant to chemotherapy. Given its biological parallels to hormone receptor-positive breast cancer, including responsiveness to anti-estrogen therapies, we conducted a pilot phase II study to assess clinical benefit of neoadjuvant fulvestrant and abemaciclib in women with advanced, unresectable LGSOC (NCT03531645). Imaging assessments were performed every 8 weeks until resectable.
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