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Sex-specific APOE4-dependent innate immunity regulates meningeal lymphatics, brain lipids, neuroinflammation, and cognition
Keywords APOE4 sexual dimorphism meninges macrophages lymphatic drainage CSF1R inhibitor brain lipids neuroinflammation cognition human brain leukocytes Introduction Apolipoprotein E (APOE) is the main lipid carrier in the brain. The human APOE gene has three polymorphic alleles, namely APOE2, APOE3 (E3), and APOE4 (E4).
Severe thrombotic complications secondary to antiphospholipid syndrome and undiagnosed systemic lupus erythematosus
KEY POINTS Antiphospholipid syndrome (APS) is an autoimmune condition characterized by the production of autoantibodies and is associated with venous, arterial or small-vessel thrombosis and obstetric complications.
Arrhythmias from the Right Ventricular Moderator Band: Diagnosis and Management
Login or register to view PDF. Abstract The moderator band in the right ventricle is being increasingly recognised as a source for arrhythmias in the absence of identifiable structural heart disease. Because it carries part of the conduction system from the right ventricle septum to the free wall, it is a source of Purkinje-mediated ventricular arrhythmias that manifest as premature ventricular contractions (PVC) or repetitive ventricular tachycardia.
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