1 Introduction Heart failure (HF) remains a growing public health concern, affecting approximately 6.7 million adults over the age of 20 in the United States (US) alone [1]. This burden is predicted to increase, with US prevalence rates expected to reach 8.7 million by 2030 and 11.4 million by 2050. Despite advances in our understanding of HF pathogenesis, mortality rates have steadily increased since 2012.