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original posts at bsky.app/profile/bowtiepolitics.bsky.social. here: mostly RTs
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Correction to: Nature Communications https://doi.org/10.1038/s41467-026-69622-7, published online 27 February 2026 In the version of this article initially published, funding information did not acknowledge the sponsor of the trial is the Frankfurt Institute of Clinical Cancer Research IKF GmbH and that financial support and drug supply for the conduct of the trial was granted by Bristol-Myers Squibb GmbH & Co. KGaA, while the title was incomplete and did not reference the Institut für...
Abstract This multi-cohort study evaluates whether dual immune checkpoint inhibition with nivolumab and ipilimumab in parallel or sequentially, or triplet chemotherapy with nivolumab can enhance efficacy as first-line therapy for advanced or metastatic gastroesophageal adenocarcinoma. Patients are randomized 1:1 to Arm A (mFOLFOX + nivolumab 240 mg every two weeks + ipilimumab 1 mg/kg every six weeks in parallel or Arm B (mFOLFOX).
Abstract Aberrant cellular signaling underlies cancer development and progression. Identifying alterations in these pathways yields critical insights for personalized oncology. Clinically, assessing the activation status of signaling proteins complements genetic and histopathological analyses, improving therapeutic evaluation and accuracy.
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