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Articles by Michael Gillette
Study finds biomarkers, drug targets, risk factors for most common form of lung cancer
By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never smoked. These factors include a pattern of DNA damage and signatures of exposures to chemicals found in processed foods and cosmetics. The findings could lead to better precision medicine strategies for this most common type of lung cancer.
Study finds biomarkers, drug targets, risk factors for most common form of lung cancer
By analyzing tens of thousands of genes, proteins, and protein modifications in hundreds of lung tumors, an international research team has uncovered new factors linked to poor outcomes in lung adenocarcinoma in both smokers and people who have never smoked. These factors include a pattern of DNA damage and signatures of exposures to chemicals found in processed foods and cosmetics. The findings could lead to better precision medicine strategies for this most common type of lung cancer.
Integrative analysis of lung adenocarcinoma across diverse ethnicities and exposures
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Keywords proteogenomics lung adenocarcinoma genomics mass spectrometry PTMs biomarkers smokers never-smokers CPTAC ICPC Introduction Lung adenocarcinomas (LUAD), the most prevalent subtype of non-small cell lung cancers (NSCLC), represent a significant global health challenge with marked geographical and epidemiological diversity in incidence and disease progression.1 Despite advances in targeted therapies and improved diagnostic techniques, LUAD continue to exhibit high mortality rates,2...
By Shankha Satpathy, Natalie Clark, Yi-Ju Chen, Noshad Hosseini, Ya-Hsuan Chang, Yi Hsiao, Jonathan T. Lei, Francesca Petralia, Jin-Shing Chen, Yifat Geffen, David Heiman, Indranil Paul, Hanbyul Cho, Michelle Hollenberg, Giacomo B Marino, Kuen-Tyng Lin, Rahul Mannan, C. White, Joe Allen, Shayan C. Avanessian, M. Kane, Ashley Wolfe, Wenke Liu, Shankara Anand, Mong-Wei Lin, Moe Haines, Erik Bergström, Grant A. Hussey, Ginny Xiaohe Li, Deepak Mani, Hao Fang, Eric J. Jaehnig, Hasmik Keshishian, Kang-Yi Su, Yi-Jing Hsiao, Hsao-Hsun Hsu, Min-Shu Hsieh, Kuo-Hsuan Hsu, Simone Gohsman, John R. Thorup, Yamei Deng, Yo Akiyama, Eden Z. Deng, Eric Chen, Azra Krek, Rodrigo Espinoza, Weiping Ma, Daniel Charytonowicz, Robert Sebra, Jyun-Hong Lin, Yin-Chen Hsu, Kun-Chieh Chen, Yu-Tai Wang, Alexander J. Lazar, Mehdi Mesri, Xu Zhang, Karl R. Clauser, David Fenyö, Arul M. Chinnaiyan, Bing Zhang, Kelly V. Ruggles, Chelsea Newton, Pei Wang, Galen Hostetter, Gilbert S. Omenn, Chandan Kumar-Sinha, Ramaswamy Govindan, Paul K. Paik, Abhijit Parolia, QING LI, Avi Ma’ayan, Gad Getz, Saravana M. Dhanasekaran, Ana I. Robles, Gee-Chen Chang, Pan-Chyr Yang, Sung-Liang Yu, Hsuan-Yu Chen, Alexey I. Nesvizhskii, Steven Carr, D.R. Mani, Marcin Cieslik, Yu-Ju Chen, Michael Gillette, Chao-Wen Lu, Cheng-Hsiang Chu, Chia-Li Han, Chien-Yu Lin, Ching-Wen Chen, Chung-Hsien Lin, Hsiang-En Hsu, Jia-Jun Wu, Pei-Hsing Chen, Pei-Rong Huang, Wan-Chun Lai, Xu-Heng Chiang, Ya-Ling Chang, Yan-Ming Chen, Yi-Ling Chen, Yi-Wen Wang, Yi-Wei Lin, Yu-Cheng Chang, Yu-Ting Huang, Zhe-Rong Zheng, Akhilesh Pandey, Alexander Pilozzi, Alex Webster, Amanda G. Paulovich, Andrew Godwin, Barbara L Pruetz, Bart O. Williams, Brian Druker, Daniel Rohrer, Daniel Chan, Danail Petrov, Elizabeth Duffy, George Wilson, Grace Zhao, Jan Lubinski, Jasmine Huang, Jason M. Hafron, Jeffrey W. Tyner, John M. Koomen, Maciej Wiznerowicz, Marcin Domagalski, Meenakshi Anurag, Nathan Edwards, Paul D Piehowski, Qin Li, Rafael Fonseca, Rashna Madan, Ross Bremner, Sandra López Cerdá, Shuang Cai, Tao Liu, Thomas A. Bauer, Xiaojun Jing, Yuping Zhang, Zoran Andrić, Miloni Kinarivala, Brecca Miller, Alexi Monovoukas, Yan-Si Chen, Ze-Shiang Lin, Chang-Wei Yeh, Eunkyung An, Mathangi Thiagarajan, Chi-Ya Shen, Chien-Chia Lin, Hsing-Jui Tsai, Jing-Wei Lin, Juani Waniwan, Ki-Hok Liao, Sin-Ming Huang, Tai-Ching Lin, Wei-Tzu Chiu, Yuju Lien, Abdul Samad Hashimi, Adrij Mohan, Aniket Dagar, David Chesla, Diwakar Davaar, Iga Kołodziejczak, Kakhaber Zaalishvili, Karen A. Ketchum, Melissa Borucki, Negin Vatanian, Pamela Grady, Popovici Bogdan, Ratna R. Thangudu, Reese Crispen, Ronald Matteotti, Sandra L. Cottingham, Shirley Tsang, William W. Maggio, Yvonne Shutack
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Cell Press
Verified
Proteogenomic analysis of the CALGB 40601 (Alliance) HER2+ breast cancer neoadjuvant trial reveals resistance biomarkers
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Clinical trial details The study design and pCR (pathological complete response) outcomes of the CALGB 40601 trial (NCT00770809) have been previously published.4 In this study, a total of 305 untreated women newly diagnosed with stage II and III HER2-positive breast cancer were randomly assigned to different treatment groups.
By Eric J. Jaehnig, Aranzazu Fernández-Martínez, Matthew Holt, Jonathan T. Lei, Beom-Jun Kim, Yongchao Dou, Haoquan Zhao, Viktoriya Korchina, Richard A Gibbs, Harshavardhan Doddapaneni, Charles M. Perou, Lisa Carey, Ana I. Robles, Terry Hyslop, Yujia Wen, Azra Krek, Francesca Petralia, George Miles, Shyam M. Kavuri, Michael Gillette, D.R. Mani, Steven Carr, Bing Zhang, Matthew Ellis, Shankha Satpathy, Meenakshi Anurag, Tanmayi D. Vashist, LaTerrica Williams, Donna Marie Muzny, Linda McCart
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Cell Reports Medicine
Verified
"Acute Tubular Injury in a Patient on a Proprotein Convertase Subtilisi" by June K Pickett, Maulin Shah et al.
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Bond Lifestyle Holiday Gift Guide 2023
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Workflow enabling deepscale immunopeptidome, proteome, ubiquitylome, phosphoproteome, and acetylome analyses of sample-limited tissues - Nature Communications
PDX and human tumor samples and cell lines All experiments with live mice were performed according to institutional and national regulations and approved by the Institutional Animal Care and Use Committee at Washington University in St.Louis, MO. Patient-derived xenograft (PDX) tumors from established basal (WHIM6) and luminal (WHIM20) breast cancer subtypes were raised subcutaneously in 8-week-old NOD. Cg-Prkdcscid Il2rgtm1Wjl/SzJ mice (Jackson Labs, Bar Harbor, ME)44,83.
Cancer proteogenomics: current impact and future prospects - Nature Reviews Cancer
Abstract Genomic analyses in cancer have been enormously impactful, leading to the identification of driver mutations and development of targeted therapies. But the functions of the vast majority of somatic mutations and copy number variants in tumours remain unknown, and the causes of resistance to targeted therapies and methods to overcome them are poorly defined.
New member interested in seeing if the previous owner of my car is a member
New member interested in seeing if the previous owner of my car is a member Hello everyone I am fairly confident that I own a car I've seen on here before, I believe it to be the car that was blown up by the upholstery shop, if the previous owner is still on here id like to discuss some things about the car to see if it is indeed the same car
Letter: Senate Must Vote to Convict
Letter: Senate Must Vote to Convict Numerous recent letters to the editor have urged removing the current president from office. Trump could be removed for conviction on his second impeachment charge. That would prevent him from holding federal office again. Failing that, retired Arizona Supreme Court Chief Justice Feldman's suggestion in his 1/14/21 opinion letter regarding Representative Finchem et al could be brought to bear.
Improving the Identification of Therapeutic Vulnerabilities in Breast Cancer
Researchers at Baylor College of Medicine, the Broad Institute of MIT, and Harvard have applied powerful proteogenomics approaches to better understand the biological complexity of breast cancer. Matthew Ellis MD, BChir, BSc., Ph.D., FRCP, serves as director of the Lester and Sue Smith Breast Center at Baylor. He is a world-renowned clinician and researcher of the molecular profiling of breast cancer. Ellis is a native of the United Kingdom.
The grace of humility
In some ways, COVID-19 seems made for our times: a disease that actually moves faster than the news cycle. And yet treating patients with COVID-19 is what I imagine practicing medicine at the end of the 19th century was like—illnesses partially understood, every physician a half-scientist, and limited (sometimes questionable) therapeutics. Then, as now, our crude clinical tools were on the cusp of being replaced with life-changing treatments.
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Under a Creative Commons license open access Highlights • Comprehensive LUAD proteogenomics exposes multi-omic clusters and immune subtypes • Phosphoproteomics identifies candidate ALK-fusion diagnostic markers and targets • Candidate drug targets: PTPN11 (EGFR), SOS1 (KRAS), neutrophil degranulation (STK11) • Phospho and acetyl modifications denote tumor-specific markers and druggable proteins Summary To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic...
Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
Highlights • Comprehensive LUAD proteogenomics exposes multi-omic clusters and immune subtypes • Phosphoproteomics identifies candidate ALK-fusion diagnostic markers and targets • Candidate drug targets: PTPN11 (EGFR), SOS1 (KRAS), neutrophil degranulation (STK11) • Phospho and acetyl modifications denote tumor-specific markers and druggable proteins Summary To explore the biology of lung adenocarcinoma (LUAD) and identify new therapeutic opportunities, we performed comprehensive...
New blood test could be used to help millions infected with TB
Rushdy Ahmad (left) and the research team worked with staff at the Public Health Laboratory-Ivo de Carneri on the Tanzanian island of Pemba to obtain blood samples from patients with suspected tuberculosis for the study. Credit: Rushdy Ahmad New blood test could be used to help millions of people infected with tuberculosis More than 10 million people around the world have active tuberculosis (ATB), and every year more than a million die from it.
Triage Test for Tuberculosis Spots Infections Within an Hour
Measuring a particular set of proteins in the blood can distinguish patients with active tuberculosis infections from those with similar respiratory symptoms, according to a report in Science Translational Medicine today (October 23). The accuracy of the test, which delivers results in under an hour, comes close to that recommended by the World Health Organization for an until-now elusive TB triage test.
Febrile Illness Evaluation in a Broad Range of Endemicities (FIEBRE)
Explore more Centres, Projects and Groups Welcome Bottom Content About About FIEBRE The objective of FIEBRE is to provide evidence: on the most common infectious causes of fever; on antibiotic susceptibility of bacterial causes; on how local perceptions of fever affect treatment practices including the use of diagnostics and antimicrobial drugs; to inform clinical guidelines and algorithms on how to manage non-malarial fevers.
A Husband and Wife Story: Men's Health.com
SHE STEPS INTO THE ROOM WEARING an attractive yellow robe, cinched tightly at the waist. It's not transparent, but it's thin enough that I can detect subtle hints of movement underneath, and loose enough to catch glimpses of her bare skin. It clings to her in all the right spots: hips, chest, her fine rear end. She looks gorgeous. Finally, my wife unties the robe, pulls it off, and places it on a chair. The move is brisk and confident—without a moment's hesitation. There she stands, au naturel.
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