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Articles by Michael Karin
Author Correction: Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce T FH differentiation
Correction to: Nature Immunology https://doi.org/10.1038/s41590-025-02179-7, published online 17 June 2025. In the version of this article initially published, incorrect representative images were presented in the “58 d” and “100 d” rows in Fig. 1a and the “None” row in Fig. 5q (which inadvertently duplicated the PLA (DNA/IgG) negative-control condition in Fig. 5r). The figures have been updated in the HTML and PDF versions of the article.
Editorial Expression of Concern: Carcinoma-produced factors activate myeloid cells through TLR2 to stimulate metastasis
Addendum to: Nature https://doi.org/10.1038/nature07623 Published online 1 January 2009 The Editors would like to alert the readers that concerns have been raised about Fig. 4g in this article as the immunoprecipitation appears to lack the Input loading control. Due to the age of the article, the authors could not retrieve the original data.
Advancing cancer detection and treatment using longitudinal routine clinical data
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Results To build a predictive model capable of learning cancer-associated signals from routine clinical data, we developed a unified, multimodal framework, Oncoformer, and validated it on a large-scale, multi-cohort dataset (Figure 1). The core of our study is a large-scale discovery cohort, COMPASS-Main, which includes longitudinal data from 2,810,742 individuals.
By Kai Wang, Hui XU, Cheng Tang, Xian Shen, Meihao Wang, Li N Liu, Changxi Hu, Wei Wu, Zixing Zou, Bingzhou Li, Sian Liu, Jin Ho Kang, JungHo Kong, Ting Li, Xiaoying Huang, Gang Chen, Wenyang Lu, Charlotte Zhang, Yiwen Sun, Weihong Lin, Caiwen Ou, Manson Fok, Taiwa Hou, Winston Wang, Kanmin Xue, Yun Yin, Hao Yue Zhu, Jonathan S. Gootenberg, Omar O. Abudayyeh, Michael Karin, Alexandre Loupy, John Rasko, Trey Ideker, Huiyan Luo, Eric K. Oermann, Kang Zhang, Ian Ziyar
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Cell Press
Verified
Inflammation starves antitumour immunity
When cells sense amino acids, they activate a kinase complex known as mTORC1 in a process that can regulate cancer metabolism and growth. Work now shows that in nutrient-limiting conditions, inflammatory cytokines aberrantly activate mTORC1 in cancer cells, thereby depriving cancer-screening CD8+ T cells of amino acids and causing their death.
Activated ATF6α is a hepatic tumour driver restricting immunosurveillance - Nature
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Abstract Hepatocellular carcinoma (HCC) is the fastest growing cause of cancer-related mortality and there are limited therapies1. Although endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) are implicated in HCC, the involvement of the UPR transducer ATF6α remains unclear2.
By Clementine Druelle-Cedano, Charlotte Rennert, Júlia Huguet-Pradell, Laimdota Zizmare, Pierluigi Ramadori, Vikas Ranvir, Peng Shen, Mihael Vucur, Olivia Coleman, Miray Cetin, Stefania Del Prete, Mohammad Rahbari, Aihua Sun, Li Gu, Laura Kim, Suchira Gallage, Nana Talvard-Balland, Albert Gris-Oliver, Alessio Bevilacqua, Pooja Sant, Jun-Hoe Lee, M. Simon, Sven Nahnsen, Almut Schulze, Ping-Chih Ho, Jan-Philipp Mallm, Darjus F. Tschaharganeh, Stephanie Roessler, Bertram R Bengsch, Geoffroy Andrieux, Melanie Boerries, Nisar P. Malek, Marco Prinz, Achim Weber, Robert Zeiser, Peter Bronsert, Konrad Kurowski, Robert Thimme, Detian Yuan, Tom Luedde, Roser Pinyol, Felix J. Hartmann, Michael Karin, Alpaslan Tasdogan, Christoph Trautwein, Moritz Mall, Maike Hofmann, Dirk Haller, Randal J. Kaufman, Cynthia Lebeaupin, Aikaterini Kadianaki, Niklas Vesper, Robert Stefan Piecyk, Menjie Qiu, Mirian Fernández-Vaquero, Insook Jang
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Nature
Verified
Obesity-related microbial dysbiosis as a potential modulator of tumour progression
Article metrics loading... /content/journal/acmi/10.1099/acmi.0.001055.v4 Metrics Download as PowerPoint /deliver/fulltext/acmi/7/10/acmi001055.v4.html?itemId=/content/journal/acmi/10.1099/acmi.0.001055.v4&mimeType=html&fmt=ahah References Ward ZJ, Bleich SN, Cradock AL, Barrett JL, Giles CM et al. Projected U.S. State-Level prevalence of adult obesity and severe obesity.
A Lymphotoxin-Driven Pathway to Hepatocellular Carcinoma
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Main text (Cancer Cell 16, 295–308; October 6, 2009) We, the authors of this publication, described the role of lymphotoxin signaling in the development of hepatocellular carcinoma. We have become aware of several errors involving duplicated images in the figures. Specifically, in Figure 7E (group tg1223 Tnfr1−/−), three consecutive liver sections stained for H&E, B220, and CD3 were duplicated in Figure S7B (group tg1223IKKβF/F).
By Johannes Haybaeck, Monika Wolf, Achim Weber, Ulrich Wagner, Michael Kurrer, Juliane Bremer, Pierre-Alain Clavien, Robert Thimme, Hubert Erich Blum, Sergei A. Nedospasov, Kurt Zatloukal, Muhammad Ramzan, Sandra Ciesek, Thomas Pietschmann, Patrice N. Marche, Michael Karin, Manfred Kopf, Jeffrey L. Browning, Adriano Aguzzi, Mathias Heikenwalder, Nicolas Zeller, Giandomenica Iezzi
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Cell Press
Verified
mAChR4 suppresses liver disease via GAP-induced antimicrobial immunity - Nature
Abstract Alcohol-use disorder and alcohol-associated liver disease (ALD) are major causes of death and liver transplantation1. The gut–liver axis has a crucial yet poorly understood role in ALD pathogenesis, which depends on microbial translocation.
FBP1 controls liver cancer evolution from senescent MASH hepatocytes - Nature
Abstract Hepatocellular carcinoma (HCC) originates from differentiated hepatocytes undergoing compensatory proliferation in livers damaged by viruses or metabolic-dysfunction-associated steatohepatitis (MASH)1. While increasing HCC risk2, MASH triggers p53-dependent hepatocyte senescence3, which we found to parallel hypernutrition-induced DNA breaks. How this tumour-suppressive response is bypassed to license oncogenic mutagenesis and enable HCC evolution was previously unclear.
Hexokinase 2 senses fructose in tumor-associated macrophages to promote colorectal cancer growth
Section snippets Fructose promotes tumor growth in APCmin/+ mouse model To investigate the role of fructose in CRC immune microenvironment, we employed both spontaneous adenoma and orthotopic tumor models.
Metabolic regulation of the glioblastoma stem cell epitranscriptome by malate dehydrogenase 2
Glioblastomas (GBMs) are the most prevalent and lethal primary malignant brain tumors in adults, with the current standard-of-care offering only palliation.1 GBMs exhibit the Warburg effect, or aerobic glycolysis, in which increased glucose uptake is associated with preferential production of lactate, even in the presence of oxygen.2 Cancer cells dysregulate the tricarboxylic acid (TCA) cycle to sustain proliferation and generate oncometabolites that initiate and maintain tumors.3,4,5...
Multifaceted collagen-DDR1 signaling in cancer
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Collagen architecture and signaling orchestrate cancer development
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Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells | Proceedings of the National Academy of Sciences
Skip to main content Angiotensin II receptor inhibition ameliorates liver fibrosis and enhances hepatocellular carcinoma infiltration by effector T cells Li Gu, Yahui Zhu, Maiya Lee, +9 , Albert Nguyen, Nicolas T. Ryujin, Jian Yu Huang, Shusil K. Pandit, Shadi Chamseddine, Lianchun Xiao, Yehia I. Mohamed, Ahmed O.
Oxidized mitochondrial DNA: a protective signal gone awry
The origin and diversification of mitochondria. Curr. Biol. 2017; 27: R1177-R1192 Chakrabarty R.P. Chandel N.S. Beyond ATP, new roles of mitochondria. Biochem. (Lond.). 2022; 44: 2-8 The rise of oxygen in Earth's early ocean and atmosphere. Nature. 2014; 506: 307-315 Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context. Cell Metab. 2021; 33: 2464-2483 Rubalcava-Gracia D. et al. No role for nuclear transcription regulators in mammalian mitochondria?. Mol. Cell.
“Sweet death”: Fructose as a metabolic toxin that targets the gut-liver axis
Abdel-Sayed A. Binnert C. Lê K.A. Bortolotti M. Schneiter P. Tappy L. A high-fructose diet impairs basal and stress-mediated lipid metabolism in healthy male subjects. Br. J. Nutr. 2008; 100: 393-399 Adelman R.C. Ballard F.J. Weinhouse S. Purification and properties of rat liver fructokinase. J. Biol. Chem. 1967; 242: 3360-3365 Ahlfors H. Morrison P.J. Duarte J.H. Li Y. Biro J. Tolaini M. Di Meglio P. Potocnik A.J. Stockinger B.
Targeting cancer-promoting inflammation - have anti-inflammatory therapies come of age?
1. Greten, F. R. & Grivennikov, S. I. Inflammation and cancer: triggers, mechanisms, and consequences. Immunity 51, 27–41 (2019). CAS PubMed PubMed Central Article Google Scholar 2. Grivennikov, S. I., Greten, F. R. & Karin, M. Immunity, inflammation, and cancer. Cell 140, 883–899 (2010). CAS PubMed PubMed Central Article Google Scholar 3. Balkwill, F. & Mantovani, A. Inflammation and cancer: back to Virchow? Lancet 357, 539–545 (2001). CAS PubMed Article PubMed Central Google Scholar 4. Diakos, C. I., Charles, K.
Pas de Deux: Control of Anti-tumor Immunity by Cancer-Associated Inflammation
Alspach E. Lussier D.M. Schreiber R.D. Interferon γ and Its Important Roles in Promoting and Inhibiting Spontaneous and Therapeutic Cancer Immunity. Cold Spring Harb. Perspect. Biol. 2019; 11: a028480 Ammirante M. Shalapour S. Kang Y. Jamieson C.A.M. Karin M. Tissue injury and hypoxia promote malignant progression of prostate cancer by inducing CXCL13 expression in tumor myofibroblasts. Proc. Natl. Acad. Sci. USA. 2014; 111: 14776-14781 Arpaia N. Campbell C. Fan X. Dikiy S. van der Veeken J. deRoos P. Liu H.
The Fire within: Cell-Autonomous Mechanisms in Inflammation-Driven Cancer
Afshar-Kharghan V. The role of the complement system in cancer. J. Clin. Invest. 2017; 127: 780-789 Amundadottir L.T. Pancreatic cancer genetics. Int. J. Biol. Sci. 2016; 12: 314-325 Amundadottir L. Kraft P. Stolzenberg-Solomon R.Z. Fuchs C.S. Petersen G.M. Arslan A.A. Bueno-De-Mesquita H.B. Gross M. Helzlsouer K. Jacobs E.J. et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat. Genet. 2009; 41: 986-990 Aran D. Lasry A. Zinger A. Biton M.
Publisher Correction: The gut-liver axis and the intersection with the microbiome
In the original version of Table 1 published online, upward arrows to indicate increased translocation of PAMPs were missing from the row entitled ‘Translocation’ for both the column on alcoholic liver disease and nonalcoholic fatty liver disease. This error has now been updated in the PDF and HTML version of the article.
Fatty Acid-Induced T Cell Loss Greases Liver Carcinogenesis
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