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Articles by Michael Ott
Author Correction: In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial
Correction to: Nature Medicine https://doi.org/10.1038/s41591-026-04254-4, published online 3 March 2026. In the original version of this article, Table 1 contained errors in the baseline apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1) values. These errors resulted from a transcription error during unit conversion from g/L to mg/dL, in which the ApoB and ApoA1 rows were inadvertently misaligned with the adjacent HDL-C and non-HDL-C rows, respectively.
3 Strategies To Reduce AI Sycophancy In Legal Work
By Michael Ott · October 28, 2026, 11:45 AM EDT By now, every lawyer knows the artificial intelligence hallucination story: fake cases, sanctions orders, a public database tracking more than 2,000 court decisions and counting.... To view the full article, register now.
3 Strategies To Reduce AI Sycophancy In Legal Work
By Michael Ott ( October 28, 2026, 11:45 AM EDT) -- By now, every lawyer knows the artificial intelligence hallucination story: fake cases, sanctions orders, a public database tracking more than 2,000 court decisions and counting.... Law360 is on it, so you are, too. A Law360 subscription puts you at the center of fast-moving legal issues, trends and developments so you can act with speed and confidence.
Investing in Tulare's fire & emergency service future - The Sun-Gazette Newspaper
In Tulare, public safety is not an abstract idea. It is the peace of mind a family feels when help arrives quickly in an emergency, the confidence a business owner has that responders are ready when needed, and the trust a community places in the people who serve it every day. For the Tulare Fire Department, that responsibility grows more demanding as our city continues to expand. Growth is something to celebrate. New homes, new businesses and new neighborhoods means Tulare is moving forward.
Op-Ed: Tulare needs to continue investing in long-term public safety priorities
In Tulare, public safety is not an abstract concept. It is the peace of mind a family feels when help arrives quickly during a medical emergency. It is the confidence a business owner has that trained responders are ready when disaster strikes. And it is the trust a community places in the people who answer the call, day and night. As Tulare grows, that responsibility grows with it.
The Intellectual Partner | JD Supra
At the beginning of Star Trek IV: The Voyage Home -you know, the one with the whales (stay with me here)-the newly reborn Spock is completing a battery of tests administered by a Vulcan educational computer. The machine challenges him across disciplines: mathematics, astrophysics, history, logic, technical specifications. It demands synthesis, presses him to reason under pressure, and moves fast enough to keep a half-Vulcan genius working to keep up.
Use of Artificial Intelligence and Risk to Privileged Information
Generative AI tools like ChatGPT, Claude, Harvey, and Microsoft Copilot are increasingly being used to research legal questions, review documents, summarize information, and draft content. While these tools can be helpful, their use can also create unexpected risks to attorney‑client privilege and work product protections if not used carefully. Recent court decisions have begun to address these risks, and they have not all reached the same result. In U.S. v.
Output vs. Process: When Attorneys Should, and Shouldn't, Use AI
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Output vs. Process: When Attorneys Should — and Shouldn't — Use AI
Credit: InfiniteFlow/Adobe Stock Two attorneys receive the same deposition transcript on the same Monday morning. The first feeds it to an AI tool and has an accurate summary by lunch. The second spends two days reading, highlighting, and writing by hand. Both produce useful work product. Only one made the right call — and which one depends entirely on a question neither may have asked. Not "can AI do this?" It almost always can.
Output vs. Process: When Attorneys Should — and Shouldn't — Use AI
Search Input Law.com CompassLaw.com RadarVerdict SearchScholar .China Law & PracticeLegal Dictionary Click to enter your existing username and password or create a new account. Click to purchase an individual user subscription with your credit card. Related information Law Firms/Representation Topics Expert OpinionArtificial Intelligence Clients have pushed back on what they are willing to pay for since long before anyone heard of a large language model.
Output vs. Process: When Attorneys Should — and Shouldn't — Use AI
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The Confidence Dashboard: Why AI Humility Beats AI Accuracy
Imagine a junior associate who delivers every memo with identical confidence. “The controlling case is Smith v. Jones,” she says, whether she has spent three hours confirming the citation or is half-remembering something from law school. “The statute of limitations is two years,” she announces with the same unwavering certainty, regardless of whether she checked the code or is simply guessing. You would not tolerate this associate for long.
The Confidence Dashboard: Why AI Humility Beats AI Accuracy
Search Input Law.com CompassLaw.com RadarVerdict SearchScholar .China Law & PracticeLegal Dictionary Click to enter your existing username and password or create a new account. Click to purchase an individual user subscription with your credit card. Related information Topics Expert OpinionArtificial Intelligence There is a paradox at the heart of AI trustworthiness: The path to being trusted is admitting when you are uncertain.
Im Einzelhandel gab es auch einige Schnäppchen zu ergattern.
Ende vergangenen Jahres belebten die Mitglieder der Werbegemeinschaft Illertissen das Weihnachtsgeschäft mit attraktiven Adventsrabatten. Mit den in Illertissen gestreuten Rabatt-Coupons konnten im Illertisser Einzelhandel Schnäppchen ergattert werden und zeitgleich nahm man an der Verlosung von Illertisser-Stadtgutscheinen teil. Die zwei Hauptpreise über je 50 Euro wurden vor Kurzem nun feierlich überreicht.
Review: Toronto’s Top TV detectives return in season 3 premiere of Law & Order Toronto: Criminal Intent
Season 3 of Law & Order Toronto: Criminal Intent premiered last week on CityTV The episode featured a story seemingly ripped from the headlines Performances by stars Kathleen Munroe and Aden Young are highlights Toronto’s favourite TV crime drama is back. The very Canadian Law & Order Toronto: Criminal Intent returns for season three on CityTV March 5 and finally feels like it’s hit its stride.
Preclearance to the U.S. is coming to Toronto’s Billy Bishop Airport
Travellers heading to the U.S. from YTZ can now obtain customs clearance before their flight instead of when they land. No further inspection will be required upon landing, and travellers can head to their next destination immediately after deboarding. The federal government says the new system could allow for the opening of routes to new U.S. destinations. Travellers bound for U.S. destinations can now receive customs preclearance for their flight instead of after landing.
Here are 13 Toronto events for the girls this International Women’s Day
This Sunday is International Women’s Day 2026, meaning there are a ton of events taking place around Toronto in observance and celebration. This year’s IWD theme is “Give to Gain,” a worldwide call to contribute to causes and organizations in your community that further gender equality. Check out these IWD events for a chance to contribute, support, and celebrate.
In vivo base editing gene therapy for heterozygous familial hypercholesterolemia: a phase 1 trial - Nature Medicine
Abstract Heterozygous familial hypercholesterolemia is a common genetic disorder characterized by lifelong elevation of serum low-density lipoprotein cholesterol (LDL-C) and premature atherosclerotic cardiovascular disease. YOLT-101 is an investigational in vivo gene therapy that uses adenine base-editing technology, delivered via GalNAc-modified lipid nanoparticles to inactivate PCSK9 and achieve sustained LDL-C reduction.
The Confidence Dashboard: Why AI Humility Beats AI Accuracy
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Spring rec programming registration opens next week in Toronto
The registration portal opens next week for Toronto’s spring recreation programming. Programs include fitness classes, sports, arts and crafts, skill training, hobby clubs, and more. The City of Toronto has announced registration dates for its spring recreation programming, which includes more than 14,000 classes, activities, and more.
Safety aspects of lithium treatment for affective disorders
Nyckelord: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bipolar disorder; schizoaffective disorders; mood disorders; lithium; mood stabilisers; drug-related side effects and adverse reactions; poisoning; drug interaction; medication adherence; toxicity; long QT syndrome; electrocardiography; systematic review; kidney; diabetes insipidus; renal insufficiency; psychotropic drugs; incidence; psykiatri; Psychiatry; Sammanfattning: Bipolar disorder (BD) and schizoaffective disorder...
Preclinical evaluation of AGT mRNA replacement therapy for primary hyperoxaluria type I disease
Zusammenarbeit über die Rhein- und Kantonsgrenze
Home Region Schweiz/Ausland Sport Agenda Magazin Die Reisegruppe aus Bad Ragazern und Maienfeldern wartet am Zugersee auf das Schiff.
Myocardial markers are highly altered by higher rates of fluid removal during hemodialysis
INTRODUCTION Hemodialysis is a lifesaving therapy in patients with kidney failure.
Comment on Liu et al. Hemodialysis Treatment for Patients with Lithium Poisoning. Int. J. Environ. Res. Public Health 2022, 19, 10044
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Comment on Liu et al. Hemodialysis Treatment for Patients with Lithium Poisoning. Int. J. Environ. Res. Public Health 2022, 19, 10044
Open AccessComment by Michael Ott 1,* and Ursula Werneke 2 1 Department of Public Health and Clinical Medicine–Medicine, Umeå University, 901 87 Umeå, Sweden 2 Sunderby Research Unit, Department of Clinical Sciences, Division of Psychiatry, Umeå University, 901 87 Umeå, Sweden * Author to whom correspondence should be addressed. Int. J. Environ. Res.
Coaching reduces resident burnout
Fainstad T, Mann A, Suresh K, Shah P, Dieujuste N, Thurmon K, et al. Effect of a Novel Online Group-Coaching Program to Reduce Burnout in Female Resident Physicians: A Randomized Clinical Trial. JAMA Netw Open. 2022;5:e2210752. • None An exploratory study of resident burnout and wellness. : • None Impostorism and anxiety contribute to burnout among resident physicians. :
Efficacy and safety of extended duration to perioperative thromboprophylaxis with low molecular weight heparin on disease-free survival after surgical resection of colorectal cancer (PERIOP-01): multicentre, open label, randomised controlled trial
Intended for healthcare professionals Toggle navigation The BMJ logo Toggle top menu Research Efficacy and safety of...
Hermès Case Could Determine How Courts Assess Trademark Rights In Connection With NFTs
The Southern District of New York has issued one of the first opinions addressing the IP implications of non-fungible tokens (NFTs) in Hermès International et al. v. Rothschild case (Case No. 22-CV-384 (JSR)). This is one of the first—but certainly not the last—IP cases involving NFTs. NFTs are uniquely identifiable digital media files "minted" using blockchain technology. The allure of NFTs derives from the exclusivity owners receive from having a digitally unique item that no one else has.
DTN Livestock Midday: Feeder Cattle Lead Futures Complex Higher
Cattle feed lot. Photo: K-State Research and Extension - Creative Commons Feeder cattle markets have rebounded from previous losses with triple-digit gains holding in nearby contracts. The focus on continued strong feeder cattle demand, despite elevated feed prices, has brought buyers back to the table at the end of the week.
DTN Livestock Open: Follow-Through Selling Pressure Expected
The livestock complex took a large hit Thursday with the greater pressure on the lean hog complex. Disappointing cash trade for hogs sent the October contract limit down. Cattle reflected the possibility of limited cattle trade and limited gains for cash cattle. Cattle: Steady Futures: Mixed Live Equiv: $216.81 +2.11* Hogs: Steady Futures: Lower Lean Equiv: $129.96 +0.16** * based on formula estimating live cattle equivalent of gross packer revenue. (The Live Cattle Equiv.
DTN Livestock Close: Limited Cash Cattle Trade, Support
Cash cattle markets have remained quiet Thursday and Friday. Most likely, needed business is done for the week. Both sides appear to be willing to hold out until next week, potentially sparking renewed interest early next week. Futures bounced higher in late-day trade, offsetting morning pressure.
DTN Fertilizer Trends: Potash, Phosphate Continue Higher, UAN Moves Lower
Corn fertilizer application. ©Debra L Ferguson Stock Photography Farmers could purchase a ton of potash for $353 last July. That same ton of fertilizer costs $549 today, according to DTN’s weekly survey of fertilizer retailers for the last week of July 2021. While the average retail cost of potash is up 15% from the same time last month, none of the seven other fertilizers tracked by DTN saw a significant increase, which DTN designates as a price change of 5% or more.
DTN Livestock Open: Export Sales May Set Direction
Cattle and hogs diverged Wednesday. Live cattle futures found support from higher cash and continued higher boxed beef prices. Feeder cattle found some support from a lower corn price. Hogs fell apart later in the day as cutouts posted substantial losses. Cattle: Higher Futures: Higher Live Equiv: $214.70 +2.58* Hogs: Steady Futures: Mixed Lean Equiv: $129.80 -4.68** * based on formula estimating live cattle equivalent of gross packer revenue. (The Live Cattle Equiv.
Soil Health: Dig a Little, Learn a Lot - DTN
Soil showing fragipan layer. Photo: Kentucky Corn Growers Association One of the best ways to measure soil health and the effectiveness of crop production practices is several feet underground. Mike Petersen gave his 1,755th soil pit talk at Grant and Tana Guetzko’s farm near Delhi, Iowa.
How to Critique Authoritarian Populism
Acknowledgements Illustrations Notes on Contributors Introduction: Frankfurt School Methodologies Jeremiah Morelock and Daniel Sullivan PART 1 Dialectics 1 When History Fails Us: Immanent Critique of Capitalism to the New Right and Beyond Robert J.
Bankruptcy Implications Of New COVID-19 Legislation
To print this article, all you need is to be registered or login on Mondaq.com. The United States Congress revived the age-old tradition of passing a lame-duck Christmas Tree appropriations bill to fund the government and provide a second wave of much-needed COVID-19 relief legislation.1 The nearly 5,600-page bill includes temporary alterations to the Bankruptcy Code to help those affected by the COVID-19 crisis.
Current Status Of Bankruptcy Remote Entities
To print this article, all you need is to be registered or login on Mondaq.com. As lenders prepare for a world with an increased risk of borrower failures, liquidations, and bankruptcies, many have begun focusing on requiring that borrowers form special purpose entities ("SPEs") to mitigate against those risks. In this publication, we explore how recent case law has viewed the formation and use of SPEs and which structures have been more effective than others.
Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion
Comments The FASEB Journal (2005) - doi: 10.1096/fj.04-2514fje issn: 0892-6638 issn: 1530-6860 pubmed: 15514102 Michael C. Ott, Jeffrey R. Scott, Aurelia Bihari, Amit Badhwar, Leo E. Otterbein, Daryl K. Gray, Kenneth A. Harris, Richard F. Potter
Geschichte des Alpenvereins: Im Schatten der Berge
Die Unterzeichneten beabsichtigen, einen Allgemeinen deutschen Alpen-Verein in’s Leben zu rufen, der sich der Durchforschung der gesammten deutschen Alpen, die erleichterte Bereisung derselben und die Herausgabe periodischer Schriften zur Aufgabe stellt.“ Ob die zehn Männer, die im Mai 1869 im Münchner Weingasthof „Zur Blauen Traube“ diesen „Aufruf an alle deutschen Alpenfreunde“ unterschrieben, ahnten, welch durchschlagender Erfolg ihrer Unternehmung beschieden sein sollte?
Rural Iowa needs better broadband access
Guest Columnist Columns are the opinion of the author, and include both facts and the individuals personal perspective. Community members are encouraged to submit guest columns up to 600 words for consideration. Sat., September 07, 2019 A Rantizo unmanned aerial vehicle sits on the ground near a vineyard at Fireside Winery, 1755 P Avenue, in Marengo, Iowa, on Friday, April 26, 2019.
How Edmonton became a political battleground for queer students’ rights
Bridget Stirling didn’t expect to find herself at the centre of a battle for queer rights when she stood up for her students. Now, as Edmonton’s public schools become an arena for a fierce political war, she’s standing her ground. The Edmonton Public School Board trustee had a simple mission: send a letter to the province affirming the board’s support for gay-straight alliances (GSAs).
Innovative Therapies for Severe Asthma
More than 39.5 million people in the U.S. have been diagnosed with asthma, and about 3,400 deaths occur annually due to asthma complications.1 Although the prevalence of atopy and asthma have increased over the past few decades in western countries, control and outcomes are improving.2 Use of asthma protocols and early recognition by the primary care provider (PCP) are among the main reasons for trends toward decreased hospitalization and fewer asthma-related deaths.3,4 In addition to the...
New database seeks to amplify women's voices in the news media
This story was funded by the J-Source Patreon campaign “We couldn’t find any expert women,” cannot be an excuse. That’s the mantra of a new website dedicated to amplifying women’s voices in Canadian news media. Expertwomen.ca seeks to create a database of women from across the country who are experts in their fields. Shari Graydon, the founder of both Expert Women and its collaborative project, Informed Opinions, said there is a severe lack of female representation as sources in journalism.
Canadian journalists can learn a lot from the US media’s Trump coverage, says Toronto Star’s Washington correspondent
By Michael Ott for the Ryerson Journalism Research Centre The loss of trust between the media and audiences that has characterised the Donald Trump era in the United States also played out when Rob Ford was mayor of Toronto, says the Toronto Star’s Washington correspondent Daniel Dale.
A Graphic Exploration of Journalism
In her new graphic novel, Rolling Blackouts: Dispatches from Turkey, Syria, and Iraq, Sarah Glidden travels across the Middle East to answer big questions about journalism. What is journalism? Is it ethical? Can a journalist’s work create substantial change? Rolling Blackouts tells the story of Glidden’s quest to study how news is produced, perceived, and consumed. The cover of Glidden’s graphic novel.
Lithium intoxication: Incidence, clinical course and renal function - a population-based retrospective cohort study
When prescribing lithium, the risk of toxicity remains a concern. In this study, we examined a cohort of patients exposed to lithium between 1997 and 2013. The aims of this study were to determine the frequency of lithium intoxication and to evaluate the clinical course and changes in renal function. Of 1340 patients, 96 had experienced at least one episode of lithium levels ⩾1.5 mmol/L, yielding an incidence of 0.01 per patient-year.
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