Michael Preuss
Black Rock
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Articles by Michael Preuss
A shared filesystem for AI agents
Hey everyone! Nico here, one of the founders of Blaxel. Agents do real work in files. The awkward part starts when two sandboxes need to share that work. Teams often end up moving artifacts through an object store, rebuilding context between runs, or creating another handoff layer. We built Agent Drive to give agents a shared place to work. Agent Drive is a distributed filesystem that multiple sandboxes can mount at the same time with concurrent read-write access.
Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorder
The authors have declared no competing interest. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Clean energy research funds under threat
President Donald Trump agreed to a critical minerals deal with Australian Prime Minister Anthony Albanese. Picture: Imago. There has been much excitement since Australia signed a landmark agreement with the United States last month to expand cooperation on critical minerals and rare earth elements. Please login below to view content or subscribe now. Membership Login
Cuts to key research facilities threaten Australia’s ability to be a global scientific leader
There has been much excitement since Australia signed a landmark agreement with the United States last month to expand cooperation on critical minerals and rare earth elements. These materials are essential for electric vehicles, wind turbines, and clean energy technologies. The deal promises to help Australia move beyond simply digging and shipping raw materials. Instead, we would refine and manufacture advanced, high-value products here at home.
Genetic subtyping of obesity reveals biological insights into the uncoupling of adiposity from its cardiometabolic comorbidities - Nature Medicine
Abstract Obesity is a heterogeneous condition not adequately captured by a single adiposity trait. We conducted a multi-trait genome-wide association analysis using individual-level data from 452,768 UK Biobank participants to study obesity in relation to cardiometabolic health. We defined continuous ‘uncoupling phenotypes’, ranging from high adiposity with healthy cardiometabolic profiles to low adiposity with unhealthy ones.
Genome‐wide associations with metabolic syndrome among UK Biobank participants reporting use of second‐generation antipsychotics
1 INTRODUCTION Second-generation antipsychotic (SGA) medications are commonly used to treat numerous mental disorders. They are, however, associated with weight gain and/or metabolic abnormalities, which can occur soon after treatment initiation.1 SGA vary in their propensities to increase the risk of weight gain and metabolic syndrome (MetS).
Genome Wide Association Study (GWAS) Identifies Novel Genetic Loci for Second‐Generation Antipsychotics (SGA)‐Induced Metabolic Syndrome (MetS)
What is the current knowledge on the topic? ○ Second Generation Antipsychotics are associated with a heightened risk of MetS. ○ Previous research has been limited to candidate gene studies and/or secondary analyses of data from clinical trials with predominantly European ancestry. What question did this study address? ○ This study primarily aimed to identify common genetic variant association of SGA-MetS in diverse patient populations using a GWAS of EHR-linked biobank data.
A Large-Scale Transcriptome-Wide Association Study (TWAS) of 10 Blood Cell Phenotypes Reveals Complexities of TWAS Fine-Mapping
Abstract Hematological measures are important intermediate clinical phenotypes for many acute and chronic diseases and are highly heritable. Although genome-wide association studies (GWAS) have identified thousands of loci containing trait-associated variants, the causal genes underlying these associations are often uncertain.
The PRIMED Consortium: Reducing disparities in polygenic risk assessment
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Keywords polygenic risk score equity diversity Introduction As genomic technologies spur progress in several areas of precision medicine, inequity in translating these advances to diverse groups has become evident.
By Iftikhar J. Kullo, Matthew P. Conomos, Sally N. Adebamowo, Ananyo Choudhury, Stephanie Fullerton, Stephanie M Gogarten, Ben Heavner, Whitney E. Hornsby, Eimear E. Kenny, Alyna khan, Amit V. Khera, Yun Li Verified, Iman K. Martin, Josep M. Mercader, Maggie Ng, Laura M. Raffield, Alex P. Reiner, Robb Rowley, Daniel J. Schaid, Adrienne M. Stilp, Ken Wiley, Riley Wilson, John Witte, Pradeep Natarajan, Clement Adebamowo, Paul L. Auer, Jennifer E. Below, Palwende Romuald Boua, Kristin Boulier, Michael Bowers, Joseph Breeyear, Nilanjan Chatterjee, Tinashe Chikowore, Jaewon Choi, Nancy Cox, Sinead Cullina, Burcu F Darst, Aaron Deutsch, Yi Ding, Todd Edwards, Eleazar Eskin, Segun Fatumo, Jose C. Florez, José Miguel Florez, José Fernando Flórez, Nelson B. Freimer, Tian Ge, Daniel H Geschwind, Chris R. Gignoux, Mark O Goodarzi, Xiuqing Guo, Christopher A. Haiman, Neil A. Hanchard, Scott Hazelhurst, Susan R. Heckbert, Jibril B. Hirbo, Kangcheng Hou, Qinqin Huang, Alicia Huerta, Guoqian Jiang, Katherine Johnston, Linda Kachuri, Takashi Kadowaki, Abram Bunya Kamiza, Sarah L. Kerns, Joohyun Kim, Iain R. Konigsberg, Charles Kooperberg, Matt Kosel, Peter Kraft, Soo-Heon Kwak, Leslie Lange, Loic Le Marchand, Hyunsuk Lee, Aaron Leong, Meng Lin, Kirk E. Lohmueller, Ruth J. F. Loos, Kevin Lu, Alisa Manning, Alicia Martin, Hilary Abom Martin, Rasika A. Mathias, James B Meigs, Rachel Mester, Mariah C. Meyer, Tyne Miller-Fleming, Braxton D. Mitchell, Nicola Mulder, Jie Na, Kristjan Norland, Loes Olde Loohuis, Suna Onengut-Gumuscu, Roel A. Ophoff, Päivi Pajukanta, Bogdan Pasaniuc, Aniruddh Patel, Ulrike Peters, Jimmy Phuong, Michael Preuss, Bruce M. Psaty, Michèle Ramsay, Kenneth Rice, Stephen F. Rich, Jerome I. Rotter, Yunfeng Ruan, Lori C. Sakoda, Philip Schroeder, Jonathan A Shortt, Megan Shuey, Xueling Sim, Roelof A.J. Smit, Johanna Smith, Lucia Sobrin, Daniel O. Stram, Ken Suzuki, Lukasz Szczerbinski, Ran Tao, Bamidele Tayo, Timothy Thornton, Buu Truong, Miriam S. Udler, David van Heel, Luciana B. Vargas, Vidhya Venkateswaran, YING WANG, Jennifer A. Wessel, Laura Wiley, Lynne R Wilkens, Genevieve L Wojcik, Quenna Wong, Toshimasa Yamauchi, Lisa R. Yanek, Yue Stell Yu, Haoyu Zhang, Yuji Zhang, Michael Zhong, Nicholette Allred, Ethan Lange, Ravi Mandia, Ebuka Oneyobi, Bryce Rowan, Siram Sankararaman, Dan Schaid, Dan Schrider, Ruhoilah Shemirani, Lauren Stalbow, Teresa Tusie, David Conti
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The American Journal of Human Genetics
Verified
Connectivity: Ultra-Responsive ERA™ Chip at the Heart of Infinio
Discover the revolutionary ERA chip at the core of Infinio, providing unparalleled connectivity and versatility. With future-ready compatibility and seamless device switching, ERA sets a new standard for stability, speed, and efficiency, ensuring better connections both indoors and outdoors. Experience the next level of digital signal processing and enjoy a full day of listening with ERA's energy-efficient technology.
Multi-ancestry genome-wide association study of major depression aids locus discovery, fine mapping, gene prioritization and causal inference - Nature Genetics
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Abstract Most genome-wide association studies (GWAS) of major depression (MD) have been conducted in samples of European ancestry. Here we report a multi-ancestry GWAS of MD, adding data from 21 cohorts with 88,316 MD cases and 902,757 controls to previously reported data. This analysis used a range of measures to define MD and included samples of African (36% of effective sample size), East Asian (26%) and South Asian (6%) ancestry and Hispanic/Latin American participants (32%).
By Xiangrui Meng, Daniel F Levey, Dora Koller, Mark Adams, Miguel E. Rentería, Dan Stein, Megan Campbell Verified, Sarah Finer, Andrew McQuillin, V. Kartik Chundru, qin huang, Chia-Yi Chu, Po-Hsiu Kuo, Hsi-Chung Chen, Shih-Jen Tsai, Kenneth S. Kendler, Roseann E. Peterson, Na Cai, Yu Fang, Laura Scott, Margit Burmeister, Michael Preuss, Lea K. Davis, Derek E. Wildman, Robert J. Ursano, Ronald Kessler, Masahiro Kanai, Yukinori Okada, Saori Sakaue, Brion Maher, Carlos S. Cruz-Fuentes, Gabriela A. Martinez-Levy, Adrian Campos Verified, Iona Y. Millwood, Sylvia Wassertheil-Smoller, Nicholas Martin, Brittany Mitchell, Enda M. Byrne, Stephan Ripke, BioBank Japan Project, Tamar Sofer, Robin G Walters, Andrew McIntosh, Andrew Mcintosh, Renato Polimanti, Murray B. Stein, Joel Gelernter, Cathryn M. Lewis
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Nature
Verified
BridgePRS leverages shared genetic effects across ancestries to increase polygenic risk score portability - Nature Genetics
Abstract Here we present BridgePRS, a novel Bayesian polygenic risk score (PRS) method that leverages shared genetic effects across ancestries to increase PRS portability. We evaluate BridgePRS via simulations and real UK Biobank data across 19 traits in individuals of African, South Asian and East Asian ancestry, using both UK Biobank and Biobank Japan genome-wide association study summary statistics; out-of-cohort validation is performed in the Mount Sinai (New York) BioMe biobank.
Branched chain amino acids harbor distinct and often opposing effects on health and disease - Communications Medicine
Abstract The branched chain amino acids (BCAA) leucine, isoleucine, and valine are essential nutrients that have been associated with diabetes, cancers, and cardiovascular diseases. Observational studies suggest that BCAAs exert homogeneous phenotypic effects, but these findings are inconsistent with results from experimental human and animal studies.
Mosaic chromosomal alterations in blood across ancestries using whole-genome sequencing - Nature Genetics
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Abstract Megabase-scale mosaic chromosomal alterations (mCAs) in blood are prognostic markers for a host of human diseases. Here, to gain a better understanding of mCA rates in genetically diverse populations, we analyzed whole-genome sequencing data from 67,390 individuals from the National Heart, Lung, and Blood Institute Trans-Omics for Precision Medicine program.
By Yasminka A. Jakubek, Adrienne M. Stilp, Justin Wong, Zuhal Özcan, Kathleen C. Barnes, Joshua C. Bis, April P. Carson, Matthew P. Conomos, Myriam Fornage, Xiuqing Guo, Joshua Lewis, Mitchell J Machiela, Taralynn M. Mack, Rasika A. Mathias, Braxton D. Mitchell, Nathan Pankratz, Patricia A. Peyser, Michael Preuss, Bruce M. Psaty, Laura M. Raffield, Ramachandran S. Vasan, Stephen S. Rich, Jerome I. Rotter, Jennifer Smith, Jeong Yun, Yun Li Verified, Alexander Bick, Paul Scheet
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Nature
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Embracing Fear
To get content like this in your inbox, check out my Substack. The rate of change continues to increase, and embracing innovation and adaptability is critical to one's job security. In " The Fifth Discipline " by Peter Senge, he emphasizes the importance of developing a learning organization to ensure success in a rapidly changing world [1]. You and your team become indispensable assets by embracing new technologies, optimizing processes, automating tasks, and reinventing yourselves.
Untangling competition between epitaxial strain and growth stress through examination of variations in local oxidation - Nature Communications
Abstract Understanding corrosion mechanisms is of importance for reducing the global cost of corrosion. While the properties of engineering components are considered at a macroscopic scale, corrosion occurs at micro or nano scale and is influenced by local microstructural variations inherent to engineering alloys. However, studying such complex microstructures that involve multiple length scales requires a multitude of advanced experimental procedures.
Whole genome sequencing identifies structural variants contributing to hematologic traits in the NHLBI TOPMed program - Nature Communications
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Abstract Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown.
By Adrienne M. Stilp, Bjarni V Halldorsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Min-Zhi Jiang, Fritz J Sedlazeck, Joshua B. Bis, Nathalie Chami, Wonji Kim, Lisa R. Yanek, John Blangero, Michael Cho, Joanne Curran, Myriam Fornage, Joshua Lewis, Alanna C. Morrison, Michael Preuss, Bruce M. Psaty, Stephen S. Rich, Hua Tang, Albert Smith, Andrew Johnson, Rasika A. Mathias, Matthew P. Conomos, Magnus Magnusson, Nathan Pankratz, Daniel Bauer, Paul L. Auer
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Nature
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Genome-wide discovery of genetic loci that uncouple excess adiposity from its comorbidities
Abstract Obesity is a major risk factor for cardiometabolic diseases. Nevertheless, a substantial proportion of individuals with obesity do not suffer cardiometabolic comorbidities. The mechanisms that uncouple adiposity from its cardiometabolic complications are not fully understood. Here, we identify 62 loci of which the same allele is significantly associated with both higher adiposity and lower cardiometabolic risk.
Strain localisation and failure at twin-boundary complexions in nickel-based superalloys
Abstract Twin boundaries (TBs) in Ni-based superalloys are vulnerable sites for failure in demanding environments, and a current lack of mechanistic understanding hampers the reliable lifetime prediction and performance optimisation of these alloys. Here we report the discovery of an unexpected γ″ precipitation mechanism at TBs that takes the responsibility for alloy failure in demanding environments.
The role of polygenic susceptibility to obesity among carriers of pathogenic mutations in MC4R in the UK Biobank population
Loading metrics Open Access Peer-reviewed Research Article Nathalie Chami, Michael Preuss, Ryan W. Walker, Arden Moscati, Ruth J. F. Loos Nathalie Chami, Michael Preuss, Ryan W. Walker, Arden Moscati, Ruth J. F. Loos Published: July 21, 2020 https://doi.org/10.1371/journal.pmed.1003196 Figures Abstract Background Melanocortin 4 receptor (MC4R) deficiency, caused by mutations in MC4R, is the most common cause of monogenic forms of obesity.
The business of Design Thinking
One of my life principles is: Always understand the ‘why’. Friedrich Nietzsche succinctly said: He who has a why to live can bear any how. Design thinking is a method and set of frameworks that facilitates solving problems from first principles*. Design thinking encourages learning, experimentation, and solutions that are based in knowledge. Design thinking is made up of 3 things that are well acknowledge and a 4th that gets less recognition: People: what do they need?
Apolipoprotein E gene polymorphisms and intraventricular haemorrhage in infants born preterm: a large prospective multicentre cohort study
Infants born preterm are at risk of intraventricular haemorrhage (IVH) but individual susceptibility related to genes is not well defined in this vulnerable population. Apolipoprotein genotypes APOE2 and APOE4 increase the hazard of cerebral haemorrhages in adults. We investigated whether APOE is associated with prevalence of IVH and is likely to have a particular genotype.
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