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Michael Wang

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Articles

Reversible and irreversible BTK inhibition promotes stem-like functional multipotency, persistence, and antitumor efficacy of CD19-directed CAR T cells in mantle cell lymphoma

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By Yixin Yao, Yue Fei, Fangfang Yan, Xiaolin Li, Joseph McIntosh, Yang Liu Verified, Michael Wang
| Nature Verified
To the Editor, Mantle cell lymphoma (MCL) is a distinct subtype of B-cell lymphoma characterized by overexpression of cyclin D1 [1]. BTK inhibition and CD19-directed chimeric antigen receptor (CAR) T-cell therapy have achieved substantial efficacy. However, MCL frequently relapses, due to therapy resistance, immune escape, and failure of adoptive cell therapies [2].
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BRG1-mediated suppression of ferroptosis underlies BTK inhibitor resistance

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By Soo-Yeon Hwang, Xiangao Huang, Belem Yoval-Sánchez, Peter Martin, Caitlin Gribbin, Preetesh Jain, Michael Wang, Lalit Sehgal, Robert A Baiocchi, Inah Hwang, Alexander Galkin, Hojoong Kwak, Lapo Alinari, Selina Chen-Kiang, Jihye Paik, Helgi Nikolli, Sieun Yang, Jeongbin Heo, Maurizio DiLiberto, Hongwu Zheng
| Nature Verified
Abstract Resistance to Bruton’s tyrosine kinase inhibitors (BTKi) remains a major therapeutic challenge in B-cell malignancies. Here, we identify chromatin remodeler BRG1-mediated suppression of ferroptosis as a central mechanism of BTKi resistance in mantle cell lymphoma (MCL), in which aberrant BRG1-dependent transcription program protects cells from BTKi-induced ferroptosis by restricting reactive oxygen species (ROS) and labile iron.
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A Pilot Study of Ex-vivo High Frequency Ultrasound and Core Needle Biopsy to Improve Clinical Tumor Staging of Cancer of the Bladder.

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By Daniel Roberson, Michael Wang, Nancy Wei
| UroToday Verified
To evaluate whether high-frequency ultrasound (HF-US) and ultrasound-guided core needle biopsy (CNB) can accurately detect muscle-invasive bladder cancer (MIBC) in an ex-vivo setting. In this prospective study, patients undergoing radical cystectomy (RC) for urothelial carcinoma underwent ex-vivo HF-US of the extirpated bladder to assess depth of tumor invasion (ultrasound stage, usT). In a subset, HF-US guided CNB of the opened bladder targeted the deepest region of tumor invasion (cnbT).
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