Mingchuang Sun

Get full text access Log in, subscribe or purchase for full access. References 1. Minikes, A.M. ∙ Liu, P. ∙ Wang, H. ... HIF-Independent Oxygen Sensing Regulates Ferroptosis Mol. Cell. 2025; 85:2973-2987.e6 2. Stockwell, B.R. Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications Cell. 2022; 185:2401-2421 3. Lei, G. ∙ Zhuang, L. ∙ Gan, B. The roles of ferroptosis in cancer: Tumor suppression, tumor microenvironment, and therapeutic interventions Cancer Cell.

Results The involvement of cuproptosis in RT remains unclear. We observed a dose-dependent increase in intracellular copper levels following RT in cancer cells (Figure 1A), suggesting a potential link between RT and cuproptosis. The inductively coupled plasma mass spectrometry (ICP-MS) analysis further confirmed that RT induced an increase in copper concentrations in cancer cells (Figure 1B).

1 Introduction Esophageal cancer ranks sixth in mortality in human cancer, among which c (ESCC) accounts for approximately 90%.[1] ESCC is related to the extensive lymphatic spread and is always diagnosed at advanced stages.[2-4] Chemotherapy is crucial for ESCC patients, as it plays an irreplaceable role in postoperative adjuvant therapy and first-line treatment.[5] Cisplatin is still the foremost agent for treating ESCC, but drug resistance limits its actual effect and worsens ESCC...