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As seen in: Nature, MDPI, Science Magazine, Cell Press, Cell Reports Medicine, The Journal of Clinical Investigation, Texas Medical Center, Lung Cancer

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Articles

Cuproptosis-immunity crosstalk informs strategy to overcome immunotherapy resistance

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By Guang Lei, Zhengze Lu, Zhihao Xu, David Huo, Jian Hua Gao, Lin Tan, Ting Hong, Shengrong Wu, Mingchuang Sun, Xi Juan Zhao, Qidong Li, Xiong Chen, Yuelong Yan, Hyemin Lee, Li Zhuang, Li-Ting Ku, Nahum Puebla, Hampartsoum B. Barsoumian, Jun Yao, Lingzhi Hong, Jianjun Zhang, Hai L Tran, don gibbons, Ara A Vaporciyan, John Heymach, Chunru Lin, Eyal Gottlieb, Mingjian James You, James Welsh, Steven Lin, Xingxing Zang, Ziyi Li, Boyi Gan, Chen Braun, Jiun-Kae Jack Lee
| Cell Press Verified
Constructs and CRISPR-Cas9–mediated gene knockout and overexpression cell line generation Cell lines with knockout of target genes were generated as previously described.49,50 CRISPR-mediated KO plasmids containing gRNAs targeting FDX1, IRF1, STAT1, and JAK1 were generated in lentiCRISPR v2 (Addgene) according to the standard protocol. The sequences of sgRNAs used in the current study are listed in Table S3.
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Deciphering small sequence differences in T cell receptor-antigen pairing

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By Yi Han, Yuqiu Yang, James Z Zhu, Farjana Fattah, Mitchell von Itzstein, Minying Zhang, Casey Bermack, Peixin Jiang, Shailbala Singh, Yanhua Tian, Yifei Hu, Yafang Deng, Xiongbin Kang, Donghan M. Yang, Jialiang Liu, Chaoying Liang, Indu Raman, Chengsong Zhu, Olivia Xiao, Jonathan E. Dowell, Jade Homsi, Sawsan Rashdan, Ke Pan, Shengjie Yang, David Hsiehchen, Fangjiang Wu, John Heymach, don gibbons, Junzhou Huang, Jianjun Zhang, Cassian Yee, Alexandre Reuben, David E. Gerber, Tao Wang, Yaming Xue, Mary E. Gwin, Yvonne Gloria- McCutchen
| Nature Verified
Abstract T cells have important functions in development and disease processes through T cell receptor (TCR)-dependent activities. Many tools were developed to predict the binding between TCRs and antigens. However, one of the uncertainties is whether such tools can decipher how small changes in the TCRs or antigenic peptides contribute to binding. We develop a deep learning model, pMTnet-omni, which not only predicts the binding vs.
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SARS-CoV-2 mRNA vaccines sensitize tumours to immune checkpoint blockade - Nature Original

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By Adam Grippin, Cole Woody, Benjamin R. Schrank, Yifan Wang Verified, Yifan Ma, Kyle A. Dyson, Jordan Jafarnia, Nina Nariman, Jacob New, Gabriel Alatrash, Jack Lee, Ji-Hyun Lee, Ryan Sun, Padmanee Sharma, Jianjun Zhang, don gibbons, Jennifer Wargo, John Heymach, Wen Jiang, Elias Sayour
| Nature Verified
Abstract Immune checkpoint inhibitors (ICIs) extend survival in many patients with cancer but are ineffective in patients without pre-existing immunity1,2,3,4,5,6,7,8,9. Although personalized mRNA cancer vaccines sensitize tumours to ICIs by directing immune attacks against preselected antigens, personalized vaccines are limited by complex and time-intensive manufacturing processes10,11,12,13,14.
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