Shengrong Wu on Muck Rack

Shengrong Wu

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Articles

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

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By Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack Roth, Nicholas E Navin, Albert C. Koong, Mingjian James You, Steven Lin, Boyi Gan
| Cell Press Verified
Results The involvement of cuproptosis in RT remains unclear. We observed a dose-dependent increase in intracellular copper levels following RT in cancer cells (Figure 1A), suggesting a potential link between RT and cuproptosis. The inductively coupled plasma mass spectrometry (ICP-MS) analysis further confirmed that RT induced an increase in copper concentrations in cancer cells (Figure 1B).
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