Mark Frye
San Antonio
Former co-host Military City USA Radio
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by Mark Frye
Multi-omics analysis links kynurenic acid to lithium response in bipolar disorder
Abstract The kynurenine pathway (KP) is implicated in bipolar disorder through its effects on glutamate signaling and neuroinflammation, but its role in clinical heterogeneity and treatment response is unclear. We used a multi-omic approach to test whether KP metabolites and their corresponding genetic risk scores are associated with clinical phenotypes, particularly response to lithium.
Modulation of GABA and glutamate by ketamine in depression: A systematic review and meta-analysis of magnetic resonance spectroscopy studies
Abstract Disrupted excitation–inhibition (E/I) balance involving GABA and glutamate (Glu) is implicated in the pathophysiology of depression. Ketamine, an NMDA receptor antagonist with rapid antidepressant properties, may modulate this balance, yet proton magnetic resonance spectroscopy (¹H-MRS) studies report inconsistent findings regarding the direction, magnitude, and timing of neurochemical effects.
Temporal elements of speech in mania
Abstract Computational analysis of speech enables precise, objective measurements of a behavioral signal closely linked to manic episodes. In a prospective cohort study conducted in Rochester, MN (ClinicalTrials.gov Identifier: NCT05956340), eighteen English-speaking adults voluntarily hospitalized for a manic episode of Bipolar I Disorder between August 2023 and September 2024 were enrolled.
Thyroid Dysfunction and the Risk of Clinically Relevant Depression: A Longitudinal Cohort Study
Abbreviations and Acronyms BMI (body mass index) CCI (Charlson Comorbidity Index) CRD (clinically relevant depression) EHR (electronic health record) FT4 (free thyroxine) HR (hazard ratio) MSAC (mood stabilizer anticonvulsant) PHQ-9 (Patient Health Questionnaire-9) SARI (serotonin antagonist and reuptake inhibitor) SNRI (serotonin-norepinephrine reuptake inhibitor) SSRI (selective serotonin reuptake inhibitor) TCA (tricyclic antidepressant) THT (thyroid hormone therapy) Get full text access...
Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder
Abstract Immune dysfunction has been increasingly implicated in bipolar disorder, but the underlying mechanisms remain unclear. To address this, we profile 833 genome-wide chromatin immunoprecipitation sequencing datasets spanning five histone marks in peripheral blood immune cells from 88 Type I bipolar disorder patients and 92 controls, integrating them with whole-genome sequencing and clinical data.
Pharmacogenomics of antiepileptic drug mood stabilizer treatment response in bipolar disorder: A MoStGen Consortium study - Molecular Psychiatry
|
Abstract Identifying biological and clinical factors associated with response to mood-stabilizing medications is critical for improving bipolar disorder (BD) treatment. The Mood Stabilizer Genomics (MoStGen) Consortium was established to investigate pharmacogenomic and clinical predictors of response to treatment of BD with antiepileptic drug mood stabilizers (AMS).
By Ada Ho, Brandon J Coombes, Anthony Batzler, Vanessa Pazdernik, Richard S. Pendegraft, Michelle Skime, Narjes Bendjemaa, Bernardo Carpiniello, Martina Contu, Nina Dalkner, Frederike T Fellendorf, Giovanna Fico, Claudio Fullerton, Manuel Gardea-Resendez, Sarai Gonzalez-Garza, Nematollah Jaafari, Esther Pinilla Jiménez Verified, Oussama Kebir, Adrien Legrand, Sofia Luna-Garza, Anna Meloni, Bruno Millet, Faycal Mouaffak, Abraham J. Nunes, Claire E. O’Donovan, Pasquale Paribello, Marco Pinna, Claudia Pisanu, Edith Pomarol-Clotet, Francisco Romo-Nava, Raul Sanchez, Katie Scott, Alessio Squassina, Elisabet Vilella, Alessandro Serretti, Miguel Prieto, Eva Z Reininghaus, Susanne A. Bengesser, Alfredo Cuellar-Barboza, Marie-Odile Krebs, Boris Chaumette, Eduard Vieta, Mirko Manchia, Susan L. McElroy, Martin Alda, Mark Frye, Joanna M. Biernacka
|
Nature
Verified
Oregon city council discusses data center, associated electric costs
If you put a data center here, your electric bills are probably going to go up some in the next three to five years.
Metabolic plasticity: an evolutionary perspective on metabolic and circadian dysregulation in bipolar disorder - Molecular Psychiatry
Abstract The emerging field of metabolic psychiatry has brought mechanisms of metabolic dysfunction into focus in bipolar disorder research. In this manuscript, we propose that the metabolic features of bipolar disorder provide a new vector from which to understand the role of circadian dysfunction in this condition.
Ferroptosis as a potential molecular mechanism of bipolar disorder - Translational Psychiatry
Abstract The unclear pathogenesis of bipolar disorder (BD) poses a challenge, especially with the striking rates of comorbid medical and psychiatric disorders, treatment resistance, and premature mortality in the absence of a specific diagnostic marker. We put forward the hypothesis of ferroptosis, a recently identified iron-dependent cell death, as a potential underlying mechanism of BD.
Molecular gradients shape synaptic specificity of a visuomotor transformation - Nature
Abstract How does the brain convert visual input into specific motor actions1,2? In Drosophila, visual projection neurons (VPNs)3,4 perform this visuomotor transformation by converting retinal positional information into synapse number in the brain5. The molecular basis of this phenomenon remains unknown. We addressed this issue in LPLC2 (ref.
Editorial on: The Underappreciated Importance of Mania
In this issue of Acta Psychiatrica Scandinavica, Drs. Manchia, Miola, Tondo, and Baldessarini [1] provide an important study of individuals with unipolar mania (UPM), defined by these authors as mania or hypomania without depressive episodes.
Serotonin selectively modulates visual responses of object motion detection in Drosophila
Abstract Serotonin (5-HT) is a hormonal messenger that confers state-level changes upon the nervous system in both humans and flies. In Drosophila, lobula columnar (LC) cells are feature-detecting neurons that project from the optic lobe to the central brain, where each population forms an anatomically-distinct glomerulus with heterogeneous synaptic partners. Here, we investigated serotonin's effect on two LC populations with different 5-HT receptor expression profiles.
Suspensión del inhibidor selectivo de la recaptación de serotonina para el tratamiento con psilocibina y contribución a la recaída en la adicción al alcohol
Las investigaciones sobre el uso de psicodélicos para tratar afecciones psiquiátricas, como la depresión y la adicción, están en auge. Sin embargo, las interacciones entre estos tratamientos experimentales y los tratamientos convencionales, como los inhibidores selectivos de la recaptación de serotonina (isrs), siguen siendo áreas de estudio crítico.
SSRI Discontinuation and AUD Relapse
There is an expanding clinical trial portfolio investigating psychedelics for psychiatric conditions.1 This case report reviews a recommendation, based on early clinical observations,2 to discontinue selective serotonin reuptake inhibitor (SSRI) therapy before psilocybin treatment and the possible association with subsequent addiction relapse. Mr A is a 31-year-old businessperson with major depressive disorder, generalized anxiety disorder, and alcohol use disorder (AUD), seen for consultation.
102. Insulin Receptor Substrate 1 (IRS1) Isolated From Neuronally Derived Exosomes is Associated With Mood State in Bipolar Disorder
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.
Clinical and genetic contributions to medical comorbidity in bipolar disorder: a study using electronic health records-linked biobank data - Molecular Psychiatry
Abstract Bipolar disorder is a chronic and complex polygenic disease with high rates of comorbidity. However, the independent contribution of either diagnosis or genetic risk of bipolar disorder to the medical comorbidity profile of individuals with the disease remains unresolved.
3. Thyrotropin Suppression During Intoxication Mediates a Positive Effect of Alcohol on Kidney Function in Males
These cookies are necessary for the website to function and cannot be switched off in our systems. They are usually only set in response to actions made by you which amount to a request for services, such as setting your privacy preferences, logging in or filling in forms. You can set your browser to block or alert you about these cookies, but some parts of the site will not then work. These cookies do not store any personally identifiable information.
Reply to Sun: Dynamic and accessible pharmacogenomic results: a response to pharmacogenomic testing for antidepressant treatment selection - Neuropsychopharmacology
We thank Dr. Sun and colleagues for their timely, clinically relevant perspective on how dynamic access to pharmacogenomic testing results is critical to ensure this new knowledge can optimize the potential to inform clinical decision making.
Classifying and clustering mood disorder patients using smartphone data from a feasibility study - npj Digital Medicine
Abstract Differentiating between bipolar disorder and major depressive disorder can be challenging for clinicians. The diagnostic process might benefit from new ways of monitoring the phenotypes of these disorders. Smartphone data might offer insight in this regard. Today, smartphones collect dense, multimodal data from which behavioral metrics can be derived. Distinct patterns in these metrics have the potential to differentiate the two conditions.
Effect of non-invasive spinal cord stimulation in unmedicated adults with major depressive disorder: a pilot randomized controlled trial and induced current flow pattern | Molecular Psychiatry
Abstract Converging theoretical frameworks suggest a role and a therapeutic potential for spinal interoceptive pathways in major depressive disorder (MDD). Here, we aimed to evaluate the antidepressant effects and tolerability of transcutaneous spinal direct current stimulation (tsDCS) in MDD. This was a double-blind, randomized, sham-controlled, parallel group, pilot clinical trial in unmedicated adults with moderate MDD.
Pharmacogenomic testing for antidepressant treatment selection: lessons learned and roadmap forward - Neuropsychopharmacology
Abstract Pharmacogenomic technology is a developing field with enthusiastic interest and broad application potential. Three large, controlled studies have been published exploring the benefit of pharmacogenomically guided antidepressant treatment selection.
Association of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder | Molecular Psychiatry
|
Abstract Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consistently effective, with only 30% of patients showing a favorable response to treatment. To provide personalized treatment options for bipolar patients, it is essential to identify prediction biomarkers such as polygenic scores.
By Azmeraw T. Amare, Klaus Oliver Schubert, Janice M. Fullerton, Simon Hartmann, Sergi Papiol, Urs Heilbronner, Bárbara Arias, Joanna M. Biernacka, Hsi-Chung Chen, Sven Cichon, Cristiana Cruceanu, Piotr Czerski, J. Raymond DePaulo, Bruno Etain, Andreas J. Forstner, Mark Frye, Julie Garnham, Fernando S. Goes, Janos L. Kalman, Mojtaba Oraki Kohshour, Eva C. Schulte, Jens Wiltfang, Philipp Ritter, Julia Schmidt, Marius Koch, Joanna Hauser, Po-Hsiu Kuo, Sarah Kittel-Schneider, Ichiro Kusumi, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Alfonso Tortorella, Michael McCarthy, Michael Mccarthy, Francesc Colom, Vincent Millischer, Markus M Nöthen, Tomáš Novák, Claudia Pisanu, Andreas Reif, Eva Z Reininghaus, Guy Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Giovanni Severino, Alessio Squassina, Gustavo Turecki, Eduard Vieta, Stephanie Witt, Peter P. Zandi, Martin Alda, Marcella Rietschel, Francis J. McMahon, Scott Clark Verified, Cynthia Marie-Claire, Maria Del Zompo, Stephane Jamain, Maria Grigoroiu-Serbanescu, Jens Reimer, Cüneyt Yildiz, Kathrin Gade, Palmiero Monteleone, Katzutaka Shimoda, Pavla Stopkova
|
Nature
Verified
GABABR silencing of nerve terminals
Accepted manuscript, PDF only. Full online edition to follow. Author Accepted Manuscript PDF only version. The full online version will follow soon. Accepted Manuscript published April 4, 2023 (This version) Accepted April 3, 2023 Received September 17, 2022 Share this article Cite this article GABABR silencing of nerve terminals eLife 12:e83530. https://doi.org/10.7554/eLife.83530 Abstract Control of neurotransmission efficacy is central to theories of how the brain computes and stores information.
Columnar neurons support saccadic bar tracking in Drosophila
Gamma oscillations are believed to underlie cognitive processes by shaping the formation of transient neuronal partnerships on a millisecond scale. These oscillations are coupled to the phase of breathing cycles in several brain areas, possibly reflecting local computations driven by sensory inputs sampled at each breath.
Opinion: 5 ways businesses can prevent a costly mental health crisis Original
This op-ed is a collaboration between the mental health doctors in the United States from the National Network of Depression Centers, and Project Healthy Minds, a new millennial-driven mental health nonprofit startup focused on destigmatizing mental illness, using technology to expand access to mental health solutions, and engaging employers to tackle the mental health crisis. The opinions expressed in this commentary are the authors' own.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with Mark
Contact Mark, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack