Nacim Kerrouche on Muck Rack

Nacim Kerrouche

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Articles

Human TMEFF1 is a restriction factor for herpes simplex virus in the brain

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By Yi-Hao Chan, zhiyong Liu, Paul Bastard, Noopur V. Khobrekar, Yasuhiro Yamazaki, Qing Fan, Daniela Matuozzo, Oliver Harschnitz, Koji Nakajima, Ahmad Yatim, Darawan Rinchai, Jie Chen, Peng Zhang, Gabriele Ciceri, Jia Chen, Kerry Dobbs, Serkan Belkaya, Danyel Lee, Adrian Gervais, Kürşad Aydın, Ayşe Nur Kartal, Shuxiang Zhao, Eduardo Garcia Reino, Yoon Seung Lee, Yoann Seeleuthner, Matthieu Chaldebas, Rasheed Bailey, Lazaro Lorenzo, Soraya Boucherit, Nico Marr, Trine H. Mogensen, Melodie Aubart, Aurélie Cobat, Olivier Dulac, Melike Emiroglu, Søren R. Paludan, Laurent Abel, Luigi D. Notarangelo, Richard Longnecker, Greg Smith Verified, Lorenz Studer, Jean-Laurent Casanova Verified, Shen-Ying Zhang, Kennen M. Hutchison, Nacim Kerrouche, Mary L. Hasek, Catherine Vanhulle, Flore Rozenberg
| Nature Verified
Abstract Most cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained1,2. Here, we report on two unrelated people who had HSE as children and are homozygous for rare deleterious variants of TMEFF1, which encodes a cell membrane protein that is preferentially expressed by brain cortical neurons. TMEFF1 interacts with the cell-surface HSV-1 receptor NECTIN-1, impairing HSV-1 glycoprotein D- and NECTIN-1-mediated fusion of the virus and the cell membrane, blocking viral entry.
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