Melodie Aubart

The transition from pediatric to adult health care systems may be challenging. It should be accurately planned, especially in patients with complex epilepsies. The transition program should be holistic and personalized, addressing patients' and families' multidisciplinary needs. Diagnosis and individual needs should be evaluated during transition until the last step before the transfer to adult care.

Abstract Most cases of herpes simplex virus 1 (HSV-1) encephalitis (HSE) remain unexplained1,2. Here, we report on two unrelated people who had HSE as children and are homozygous for rare deleterious variants of TMEFF1, which encodes a cell membrane protein that is preferentially expressed by brain cortical neurons. TMEFF1 interacts with the cell-surface HSV-1 receptor NECTIN-1, impairing HSV-1 glycoprotein D- and NECTIN-1-mediated fusion of the virus and the cell membrane, blocking viral entry.

Coronavirus disease 2019 (COVID-19) owing to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was declared a world pandemic in March 2020. 1 Huang C. Wang Y. Li X. Ren L. Zhao J. Hu Y. et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. In adults, infection ranges from asymptomatic infection to severe respiratory failure.