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Articles by Nicholas Clark
ExtUtils-Constant-0.25_50
To install ExtUtils::Constant, copy and paste the appropriate command in to your terminal. For more information on module installation, please visit the detailed CPAN module installation guide.
Devel-Size-0.87
Changes for version 0.87 - 2026-03-31 Changes for version 0.86_50 - 2026-02-10 Fix the build on v5.38.5 - reported as CPAN #173167, but identified already Modules Perl extension for finding the memory usage of Perl variables To install Devel::Size, copy and paste the appropriate command in to your terminal. cpanm cpanm Devel::Size CPAN shell perl -MCPAN -e shell install Devel::Size For more information on module installation, please visit the detailed CPAN module installation guide.
Devel-Size-0.86
Changes for version 0.86 - 2026-02-10 Changes for version 0.85_50 - 2026-04-06 Modules Perl extension for finding the memory usage of Perl variables To install Devel::Size, copy and paste the appropriate command in to your terminal. cpanm cpanm Devel::Size CPAN shell perl -MCPAN -e shell install Devel::Size For more information on module installation, please visit the detailed CPAN module installation guide.
Devel-Size-0.85_50
Changes for version 0.85_50 - 2026-04-06 Modules Perl extension for finding the memory usage of Perl variables To install Devel::Size, copy and paste the appropriate command in to your terminal. cpanm cpanm Devel::Size CPAN shell perl -MCPAN -e shell install Devel::Size For more information on module installation, please visit the detailed CPAN module installation guide.
Direct and indirect viral associations predict coexistence in wild plant virus communities
Virus networks 55 Hanley J.A. Mcneil B.J. The meaning and use of the area under a receiver characteristic (ROC) curve. Radiology.
Measuring complexity of muscle force control: Theoretical principles and clinical relevance in musculoskeletal research and practice
Bali K. Dhillon M. Vasistha R. Kakkar N. Chana R. Prabhakar S. Efficacy of immunohistological methods in detecting functionally viable mechanoreceptors in the remnant stumps of injured anterior cruciate ligaments and its clinical importance. Knee Surg. Sports Traumatol. Arthrosc. 2012; 20: 75-80 Spinal interneurons providing input to the final common path during locomotion. Prog. Brain Res. 2010; 187: 81-95 Biomedical Signal Processing and Signal Modelling.
Regulatory T Cells Support Breast Cancer Progression by Opposing IFN-γ-Dependent Functional Reprogramming of Myeloid Cells
Highlights • Anti-tumor phenotype requires reprogramming of inflammatory monocytes/macrophages • Myeloid cell functional reprogramming is dependent on IFN-γ produced by CD4T cells • TAM reprogrammed transcriptome correlates with better prognosis in human cancer Summary Regulatory T (Treg) cell infiltration of solid tumors often correlates with poor prognosis, but their tumor-suppressive function lacks mechanistic understanding.
Cheminformatics Tools for Analyzing and Designing Optimized Small-Molecule Collections and Libraries
Highlights • Existing small-molecule collections vary greatly on selectivity and target coverage • A data-driven approach to library design enhances diversity and library performance • The LSP-OptimalKinase library enhances selectivity and coverage for kinome targets • The LSP-MoA library optimally targets 1,852 genes in the liganded genome Summary Libraries of well-annotated small molecules have many uses in chemical genetics, drug discovery, and therapeutic repurposing.
The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection
4e-bp Is Transcriptionally Induced by ATF4 during Infection in the Fat Body and Gut Levels of AMP Proteins, but Not Transcripts, Are Reduced in 4e-bp Mutants The 5? UTRs of Drosomycin, Attacin A, and 4e-bp Support Cap-Independent Translation Much research has focused on the transcriptional response to infection mediated by the innate immune response pathways (Buchon et al., 2014xImmunity in Drosophila melanogaster—from microbial recognition to whole-organism physiology.
The role of Pdia3-dependent 1α,25-dihydroxy vitamin D3 signaling on IgE-mediated mast cell activation
Active 1,25(OH)2 Vitamin D3 (1,25D3) is most commonly known for its role in the regulation of bone metabolism. However, research has now indicated it is a potent immune regulator beyond its calcemic effects. Vitamin D deficiency has been implicated in the pathogenesis of allergic diseases including asthma and atopic dermatitis. 1,25D3 is known to signal through the canonical Vitamin D receptor (VDR) facilitating its anti-inflammatory properties and regulating over 100 genes.
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