1 Introduction Chemical modifications are employed in oligonucleotides to improve the properties of these polymers for various applications, including therapeutics, biosensing, and materials chemistry.[1-4] Of interest are amino-modifiers given their ability to make site-specific conjugates,[5-12] and improve self-replicating processes within nonenzymatic genome replication.[13-19] Notably, certain short interfering RNA (siRNA) therapeutics conjugated with a GalNAc have made it to market...