Nirad Banskota

Abstract Aging is associated with detrimental changes in chromatin structure and gene expression, contributing to inflammation, metabolic decline and tissue dysfunction. SIRT6, a histone deacetylase, plays a key role in maintaining chromatin integrity and promoting longevity.

1 Introduction Physical activity is associated with higher skeletal muscle mitochondrial oxidative capacity [1-3]. Individuals who engage in regular physical activity exhibit higher levels of mitochondrial proteins and lower levels of splicing-related proteins in their skeletal muscle [4, 5].

Keywords senescence ER stress ATF4 translation integrated stress response ISR proteomics ribosome sequencing nanopore direct RNA sequencing senescence-associated secretory phenotype SASP Introduction Cellular senescence is a state of indefinite cell-cycle arrest that typically occurs in response to sublethal genomic damage.