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Abstract Children with cancer develop many short- and long-term side-effects of treatment1, but the amount of DNA damage associated with chemotherapy exposure is unclear2. Here we used mutational signatures to measure this damage using whole-genome-sequenced tumours from a multi-institutional cohort for which therapy dose and total exposure were uniformly collected3,4,5.
Objective To evaluate the prognostic impact of gastrointestinal involvement (GI-LCH) on the survival of children with Langerhans cell histiocytosis registered on the international clinical trials of the Histiocyte Society. Study design Retrospective analysis of 2414 pediatric patients registered onto the consecutive trials DAL-HX 83, DAL-HX 90, LCH-I, LCH-II, and LCH-III.
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