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Noah Zaitlen

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Articles

Compressing the collective knowledge of ESM into a single protein language model

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By Tuan Anh Dinh, Seon-Kyeong Jang, Noah Zaitlen, Vasilis Ntranos
| Nature Verified
Abstract Protein language models (PLMs) have recently emerged as a promising approach for next-generation variant-effect prediction (VEP). Most high-performing VEP methods currently utilize PLMs combined with additional information, such as homology, protein structure and population genetics data to improve prediction accuracy.
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Advancing precision health discovery in a genetically diverse health system

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By Roni Malishkevich Haas, Michael Margolis, Angela Wei, Takafumi N. Yamaguchi, Jeffrey Feng, Thai Tran, Veronica Tozzo, Katelyn J. Queen, Vishakha Patil, Michael E. Broudy, Paul Tung, Shafiul Alam, Danielle Martinez, Yash Patel, Christa Caggiano, Nicole Zeltser, Rupert Hugh-White, Jaron Arbet, Ruhollah Shemirani, Mao Tian, Prapti Thapaliya, Lora Eloyan, Lawrence O. Chen, Sandra Lapinska, Maryam Ariannejad, Clara M Lajonchere, Eimear E. Kenny, Bogdan Pasaniuc, Alex Bui, Valerie Arboleda, Timothy S. Chang, Noah Zaitlen, Paul T. Spellman, Paul Boutros, Daniel H Geschwind
| Cell Press Verified
Keywords health-system biobank electronic health records genomic medicine genetic association ancestry GLP-1 receptor agonists semaglutide phenome-wide association study exome-wide association study polygenic scores Introduction The integration of electronic health records (EHRs) with genetic data is transforming biomedical research, offering unprecedented opportunities for preventing and managing common medical conditions.1 Longitudinal sampling, linked with genetic and environmental data,...
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The relationship between genotype- and phenotype-based estimates of genetic liability to psychiatric disorders, in practice and in theory

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By M. Krebs, Vivek Appadurai, Kajsa-Lotta Georgii Hellberg, Henrik Ohlsson, Jette Steinbach, Emil Stig Pedersen, Thomas Werge, Jan Sundquist, Kristina Sundquist, Na Cai, Noah Zaitlen, Andy Dahl, Bjarni Jóhann Vilhjálmsson, Jonathan Flint, Silviu-Alin Bacanu, Kenneth S. Kendler, Andrew J. Schork
| The American Journal of Human Genetics Verified
Keywords genetics family genetic risk scores genetic liability polygenic risk scores psychiatric disorders Get full text access Log in, subscribe or purchase for full access. References 1. Falconer, D.S. Introduction to Quantitative Genetics Prentice Hall, Harlow, 1996 2. Lynch, M. & Walsh, B. (1998) Genetics and Analysis of Quantitative Traits. (Sinauer). 3. Goddard, M.E. ∙ Hayes, B.J. Genomic selection J. Anim. Breed. Genet. 2007; 124:323-330 4. Meuwissen, T. ∙ Hayes, B. ∙ Goddard, M.
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