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Oscar Alejandro Ojeda-Rojas

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Articles

A universal 6iL/E4 culture system for deriving and maintaining embryonic stem cells across mammalian species

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By Duo Wang, Hao Ming, Dongshan Yang, Xiang Cui, Zachary Freeman, Li-Kuang Tsai, Zhuying Wei, Liu Liu, Giovanna Scatolin, Brian Bennett Verified, Xiukun Wang, Kimberly Yau, Litao Tao, Xinyi Tong, Shuling Wang, Ben Van Handel, Longhua Guo, Xiaoting Dai, Youcai Xiong, Yinjuan Wang, Rajan Iyyappan, Guang Hu, Lynda K. McGinnis, Richard Paulson, Daniel B. McKim, Xiangbo Kong, Xiaofeng Xia, Jifeng Zhang, Y. Eugene Chen, Zongliang C. Jiang, Jie Xu, Qi-Long Ying, Kai-Xuan Shi, Denis Evseenko, Bingjing Zhang, Oscar Alejandro Ojeda-Rojas
| Nature Verified
Abstract The derivation of authentic embryonic stem cells (ESCs) across mammalian species remains a major challenge. Here, we report the development of a defined, serum-free culture system, termed 6iL/E4, that enables the derivation and long-term self-renewal of ESCs across diverse mammalian species. Through systematic dissection of signaling pathways, we identified conserved regulatory modules involving GSK3α, WNT, STAT3, PDGFR, and MEK/ERK signaling.
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