Pakavarin Louphrasitthiphol

2 1Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford, Headington, Oxford OX3 7DQ, United Kingdom; 2Area of Physiology, Faculty Health Sciences, University Rey Juan Carlos, Alcorcón, Madrid 28922, Spain; 3Champalimaud Research, Champalimaud Centre for the Unknown, 1400-038 Lisboa, Portugal; 4Department of Surgery, University Hospital Fundación Alcorcón, Alcorcón, Madrid 28922, Spain; 5Department of General Surgery, University Hospital Rey Juan...

Conflicts of Interest R.M.W. is a paid consultant to N-of-One Therapeutics, a subsidiary of Qiagen. R.M.W. receives royalty payments for the use of the casper zebrafish line from Carolina Biologicals. E.J., Y.M., M.V.H., J.H.R., P.L., C.R.G., H.M., and C.P. declare no competing interests. Supporting Information Filename Description pcmr13208-sup-0001-Figures.pdfPDF document, 65.5 MB Figure S1. Figure S2. Figure S3. Figure S4. Figure S5. Figure S6.

Abstract Phenotypic diversity of cancer cells within tumors generated through bi-directional interactions with the tumor microenvironment has emerged as a major driver of disease progression and therapy resistance. Nutrient availability plays a critical role in determining phenotype, but whether specific nutrients elicit different responses on distinct phenotypes is poorly understood.