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Articles by Pascal Schneider
Fördermittel für Energieeffizienz und Innovationen in der Oberflächentechnik
Unternehmen der Galvano- und Oberflächentechnik stehen wie viele Industriebereiche unter hohem Kosten-, Transformations- und Innovationsdruck. Gleichzeitig existiert eine Vielzahl an Förderprogrammen, mit denen Investitionen z. B. in energieeffiziente Anlagen und Prozesse, Maßnahmen zur Energie- und Ressourceneffizienz, Gebäudesanierungen sowie Forschung und Entwicklung finanziell bezuschusst werden.
Funding for Energy Efficiency and Innovation in Surface Technology
Like many other industrial sectors, companies in the electroplating and surface treatment industry face significant pressure to reduce costs, undergo transformation, and innovate. At the same time, there are a wide variety of funding programs that provide financial support for investments in, for example, energy-efficient equipment and processes, measures to improve energy and resource efficiency, building renovations, and research and development.
The liver-secreted protein FGL1 restrains a subset of innate-like B cell responses via the receptor TACI
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Keywords FGL1 TACI BAFF APRIL LAG-3 BCMA B cell inhibitory autoimmunity lupus Get full text access Log in, subscribe or purchase for full access. References 1. Zhu, Y. ∙ Yao, S. ∙ Chen, L. Cell surface signaling molecules in the control of immune responses: a tide model Immunity. 2011; 34:466-478 2. Chen, L. ∙ Flies, D.B. Molecular mechanisms of T cell co-stimulation and co-inhibition Nat. Rev. Immunol. 2013; 13:227-242 3.
By Tina Su, Jianwei He, Yuge Wang, Jiaoyan Huang, Baozhu Huang, Ala F. Nassar, Laure Willen, Mahya Eslami, ChunXiang Wu, Meiyi Huang, Jianping Zhang, Runxia Gu, Lan Ji, Ti Badri, Xuan Yang, Hyeon Jun Shin, Min-Jong Kang, Lokesh Sharma, Matthew Vesely, Yong Xiong Verified, Hongyu Zhao, Pascal Schneider, Jun Wang, Lieping Chen
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Cell Press
Verified
Rising tree mortality in France is associated with distinct seasonal climate anomalies
Abstract Tree mortality is rising across European forests, yet its dominant drivers remain difficult to disentangle. Analyzing over 500,000 trees from the French National Forest Inventory (2015-2023), we observe increasing mortality rates across major species. Using ensemble modelling and explainable machine learning, we identify tree size, competition, and seasonal climate anomalies as the primary mortality drivers.
Characterisation of the N‐Methyltransferase SgPsmC: Application in the Kinetic Resolution of Pyrroloindolines
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Un court métrage en préparation à Laruns
Diffusé le jeudi 17 juillet 2025 à 6:45 Publié le jeudi 17 juillet 2025 à 6:45 C’est au cœur de la vallée d’Ossau que la réalisatrice Cristèle Alves Meira prépare le tournage de son prochain court-métrage "Le Cri du Diable" Produit pour France 3 et plusieurs festivals. Cet été, la réalisatrice Cristèle Alves Meira est en Vallée d'Osseux afin de préparer le tournage de son prochain court-métrage : Le Cri du Diable.
Truncated LKB1 nonenzymatically enhances Fas-induced apoptosis by acting as a surrogate of Smac - Cell Death Discovery
Abstract Although liver kinase B1 (LKB1) has been established as a tumor suppressor kinase, its mechanism of action is incompletely understood. Here we describe a novel nonenzymatic function of LKB1 in cell death induced by Fas/CD95. In BID knockout HeLa cells, inactivation of mitochondrial outer membrane permeabilization (MOMP) prevents Smac-induced inhibition of X-linked inhibitor of apoptosis (XIAP), causing resistance to Fas-induced apoptosis.
Biocatalytic Amino Acid Functionalisation
The success of new therapeutic modalities relies on advancements in synthetic chemistry to produce compounds for evaluation throughout the drug discovery process. The use of non-canonical amino acids (ncAAs) allows the properties of peptide drugs to be modified and optimised beyond the defined characteristics of the 20 proteogenic amino acids.
Empirical evidence and theoretical understanding of ecosystem carbon and nitrogen cycle interactions
Contents Summary I. Introduction II. Insights from experimental manipulations III. Insights from environmental gradients IV. An optimality-guided CN-model V. Discussion VI. Conclusions Acknowledgements References I. Introduction An open challenge in understanding and modelling the terrestrial carbon (C) cycle response to climate change is to understand the role of soil nutrients and, specifically, the extent to which nitrogen (N) limits the current and future land C sink.
Schwierige Bedingungen im Sachversicherungsmarkt
Herausforderungen und Risiken für Unternehmen Bedeutende Veränderungen in der Sachschadenversicherung führen bei Unternehmen zu steigenden Versicherungsprämien und erschweren die Planbarkeit der Versicherungskosten. Exponierte Versicherungsnehmende oder solche mit Spitzenrisiken und hohen Deckungssummen kämpfen bei verschärften Anforderungen und Kapazitätsengpässen darum, eine umfassende Deckung zu erhalten.
A bioactive soluble recombinant mouse LIGHT promotes effective tumor immune cell infiltration delaying tumor growth
Abstract The TNF family member LIGHT (TNFSF14) binds to two receptors, HVEM (TNFSFR14) and LTbetaR (TNFSFR3). HVEM functions as a costimulatory molecule, whereas LTbetaR is involved in the development of lymph nodes and ectopic tertiary lymphoid structures at chronic inflammation sites. The classical approach of fusing soluble recombinant proteins to the Fc fragment of IgG resulted in a functionally inactive Ig.mouse (m) LIGHT protein.
Ancestral versus Modern Substrate Scope in Family-1 Glycosidases
Abstract Promiscuity, the capability of catalyzing a diversity of chemical reactions, is a desirable feature in many enzymes intended for biotechnological applications. Promiscuous activities, however, are typically depressed in specialized modern enzymes. On the other hand, several ancestral reconstruction studies have reported enzymes with enhanced promiscuity.
A Universal, Continuous Assay for SAM‐dependent Methyltransferases
Introduction Late-stage functionalization (LSF) of drug molecules and lead structures is an important tool for rapid molecule diversification.
A Causal Treatment for X-Linked Hypohidrotic Ectodermal Dysplasia: Long-Term Results of Short-Term Perinatal Ectodysplasin A1 Replacement
Open AccessArticle by Holm Schneider 1,*, Christine Schweikl 1, Florian Faschingbauer 2, Smail Hadj-Rabia 3 and Pascal Schneider 4 1 Center for Ectodermal Dysplasias & Department of Pediatrics, University Hospital Erlangen, Loschgestr.
Revisiting autoimmune lymphoproliferative syndrome caused by Fas ligand mutations
This paper is only available as a PDF. To read, Please Download here. Fas ligand (FasL) is expressed by activated T cells and induces death in target cells upon binding to Fas. Loss-of-function FAS or FASLG mutations cause autoimmune-lymphoproliferative syndrome (ALPS) characterized by expanded double-negative T cells (DNT) and elevated serum biomarkers. While most ALPS patients carry heterozygous FAS mutations, FASLG mutations are rare and usually biallelic.
Cluster-induced desorption/ionization mass spectrometry of highlighter ink: unambiguous identification of dyes and degradation processes based on fragmentation-free desorption
Cluster-induced desorption/ionization mass spectrometry of highlighter ink: unambiguous identification of dyes and degradation processes based on fragmentation-free desorption You have access to this article Please wait while we load your content... Something went wrong. Try again?
Biocatalytic C3‐Indole Methylation-A Useful Tool for the Natural‐Product‐Inspired Stereoselective Synthesis of Pyrroloindoles
Abstract Enantioselective synthesis of bioactive compounds bearing a pyrroloindole framework is often laborious. In contrast, there are several S-adenosyl methionine (SAM)-dependent methyl transferases known for stereo- and regioselective methylation at the C3 position of various indoles, directly leading to the formation of the desired pyrroloindole moiety.
Analysis of Complex Molecules and Their Reactions on Surfaces by Means of Cluster-Induced Desorption/Ionization Mass Spectrometry
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