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Pasha Mazin

As seen in: Nature
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Articles by Pasha Mazin

A spatiotemporal cancer cell trajectory underlies glioblastoma heterogeneity

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By Grant de Jong, Fani Memi, Tannia Gracia, Olga Lazareva, Oliver Gould, Georgios Solomou, Alexander Aivazidis, Manas Dave, Qianqian Zhang, Melanie Jensen, Ahmet Rifaioglu, João D. Barros-Silva, Sabine Eckert, Di Zhou, Elizabeth Tuck, Sezgin Er, Koen Rademaker, Robert Petryszak, Henry Marshall, Kenny Roberts, Andrew Trinh, Shreya Rai, Tyler Shaw Verified, Agnes Oszlanczi, Hayden Powell, Stanislaw Makarchuk, Yinshui Chang, Katarzyna Kania, Liying Jin, Catherine Tudor, Man Chung CHAN, Harriet Johnson, Holly Anderson, Ilaria Mulas, Annelies Quaegebeur, Mayen Briggs, Jessica Cox, Laura Rueda-Gensini, Manu Saraswat, Adam Young Verified, Minal Patel, Tarryn Porter, Moritz Gerstung, Martin Prete, Elena Prigmore, Moritz Mall, Harry Bulstrode, Julio Saez-Rodriguez, James Briscoe, David H. Rowitch, Richard Mair, Sam Behjati, Oliver Stegle, Omer Ali Bayraktar, Yvette Wood, Pasha Mazin, Benjamin Rumney, Jasmine Halliwell, Vanessa Brito Pereira, Zoi Katsirea, Irfan Mamun, Zaira Seferbevoka
| Nature Verified
Abstract Cancer cells show highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour1,2,3,4,5. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here we generated a deep single-cell and spatial multi-omic atlas of human glioblastoma that pairs transcriptomic, epigenomic and genomic profiling of 12 tumours across many regions.
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