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Patricia Barral on Muck Rack

Patricia Barral

As seen in: Cell Reports, Cell Press, King's College London, JoVE- Journal of Visualized Experiments
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Articles

IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells

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By Tom Rees Verified, Rebeca Jimeno, Nikolaos Angelis, Joseph Ng, Franca Fraternali, Vivian Li, Patricia Barral, Marta Lebrusant-Fernandez
| Cell Reports Verified
Keywords NKT cell intestinal epithelial cell intestinal organoids IFN-γ Research topic(s) CP: Immunology Introduction The intestinal epithelium performs key functions in nutrient absorption as well as acts as a barrier to preserve the compartmentalization of the intestinal microbiota. The intestinal lining consists of a monolayer of intestinal epithelial cells (IECs) that is characterized by tight regulation and large turnover capacity.
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King's researchers explain how lipids can control the immune response

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By Patricia Barral
| King's College London
The new paper from Dr Phillip Brailey, Dr Lauren Evans & Dr Patricia Barral highlights how lipids change the behaviour of macrophages which influences the overall immune response against infections and inflammatory diseases. When we consume fats (also called lipids) in our diet, they can be metabolised or stored to provide energy for the body. But they are also involved in regulating the genes expressed within, and the signalling between, cells.
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RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection

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By J. Ross Chapman, Patricia Barral, Jean-Baptiste Vannier, Valerie Borel
| Cell Press Verified
(Molecular Cell 49, 858–871; March 7, 2013) In the original published version of this article, the 53BP1 (Flag-HA) loading control HA immunoblot panel in Figure 6E was an accidental duplication of the 53BP1 (Flag-HA) pulldown HA immunoblot bands in Figure 6F. This mistake arose during figure preparation and was possible since both blots originated from a single experiment (resolved on common X-ray films), consistent with what is stated in the figure legend.
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