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Articles by Patrick B. Mark
Jackie Stewart: Ikone der Formel 1
Morgen 04:35 - 06:10 95 min. Sky Documentaries HD16:9 GB 2022 Dokumentarfilm Formel-1-Ikone Jackie Stewart im Porträt: Der dreimalige Weltmeister prägte den Rennsport wie wenige vor ihm, von seinem ersten Titel 1969 bis hin zum jahrelangen Kampf um mehr Sicherheit.
Low circulating miR-190a-5p predicts progression of chronic kidney disease - Nature Communications
Accuracy of glomerular filtration rate estimates among patients with cancer - British Journal of Cancer
Abstract Glomerular filtration rate (GFR) estimation is a key issue in determining cancer treatment eligibility and dosing of treatments with narrow therapeutic index. Yet, little is known about the accuracy of GFR estimation among people with cancer in routine care.
Spironolactone versus placebo in patients undergoing maintenance dialysis (ACHIEVE): an international, parallel-group, randomised controlled trial
Get full text access Log in, subscribe or purchase for full access. References 1. de Jager, DJ ∙ Grootendorst, DC ∙ Jager, KJ ∙ et al. Cardiovascular and noncardiovascular mortality among patients starting dialysis JAMA. 2009; 302:1782-1789 2. Drechsler, C ∙ Ritz, E ∙ Tomaschitz, A ∙ et al. Aldosterone and cortisol affect the risk of sudden cardiac death in haemodialysis patients Eur Heart J. 2013; 34:578-587 3.
Exploration of patients’ and healthcare professionals’ perspectives on kidney failure risk and the use of the kidney failure risk equation in MULTIPle lOng-term condItions aNd frailTy (MULTIPOINT) study: a qualitative interview and focus group study prot…
Ethical approval was granted in August 2023 by the NHS Health Research Authority following a favourable opinion from the West if Scotland Research Ethics Committee (REC) 3 (IRASID: 325848, REC reference: 23WS/0119, Protocol number GN22RE559). There is a possibility that individuals recruited from primary care may be unaware of their CKD diagnosis prior to recruitment, making this information new to them. This could be viewed as both a potential risk and a benefit.
Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization - Communications Medicine
Abstract The associations between deprivation and illness trajectory after hospitalisation for coronavirus disease-19 (COVID-19) are uncertain. A prospective, multicentre cohort study was conducted on post-COVID-19 patients, enrolled either in-hospital or shortly post-discharge. Two evaluations were carried out: an initial assessment and a follow-up at 28–60 days post-discharge.
Personalised lung cancer risk stratification and lung cancer screening: do general practice electronic medical records have a role? - British Journal of Cancer
Abstract In the United Kingdom (UK), cancer screening invitations are based on general practice (GP) registrations. We hypothesize that GP electronic medical records (EMR) can be utilised to calculate a lung cancer risk score with good accuracy/clinical utility. The development cohort was Secure Anonymised Information Linkage-SAIL (2.3 million GP EMR) and the validation cohort was UK Biobank-UKB (N = 211,597 with GP-EMR availability).
Diagnosis of cardiovascular disease in patients with chronic kidney disease - Nature Reviews Nephrology
Abstract Patients with chronic kidney disease (CKD) are at high risk of cardiovascular disease (CVD) and cardiovascular death. Identifying and monitoring cardiovascular complications and hypertension is important for managing patients with CKD or kidney failure and transplant recipients. Biomarkers of myocardial ischaemia, such as troponins and electrocardiography (ECG), have limited utility for diagnosing cardiac ischaemia in patients with advanced CKD.
GFR slope as a surrogate marker for future kidney failure - Nature Reviews Nephrology
Kidney failure is a serious but rare consequence of progressive chronic kidney disease. A meta-analysis of individual participant-level trial data, across heterogeneous treatments and disease groups, has shown glomerular filtration rate (GFR) slope to be a valid, fit-for-purpose and robust surrogate marker of kidney failure. Refers to Inker, L. A. et al. A meta-analysis of GFR slope as a surrogate endpoint for kidney failure. Nat. Med. https://doi.org/10.1038/s41591-023-02418-0 (2023).
Stewart
Sinopsis Nacido en 1939, Jackie Stewart es uno de los pilotos de Formula 1 más importantes de la historia. A pesar de sus humildes comienzos en las afueras de Glasgow, Stewart luchó por sus sueños y llegó a lo más alto del mundo del motor, convirtiéndose en uno de los diez pilotos que ha obtenido al menos tres títulos mundiales de F1 (en 1969, 1971 y 1973), además de sumar dos subcampeonatos y un tercer puesto, y 27 grandes premios ganados.
Oxidative Stress in End-Stage Renal Disease: Pathophysiology and Potential Interventions
Chronic kidney disease (CKD) is a major public health problem worldwide with continuously growing epidemic characteristics and heavy cardiovascular (CV) comorbidity. CKD and CV risk have a parallel course, and CV disease is the leading cause of death in end-stage kidney disease (ESKD) patients, accounting for about 50% of mortality [1].
Cardiorespiratory Optimisation By Arteriovenous fistula Ligation after renal Transplantation (COBALT): study protocol for a multicentre randomised interventional feasibility trial
http://orcid.org/0000-0003-2272-1143Veena Surendrakumar1,2, Emma Aitken3,4, Patrick Mark4, Reza Motallebzadeh5,6, James Hunter7,8, Aimen Amer9, Dominic Summers2,10, Kirsten Rennie11, Leila Rooshenas12, Madalina Garbi13, Karl Sylvester14, Cara Hudson15, Jennifer Banks15, Anna Sidders16, Andrew Norton17, Matthew Slater10, Matthew Bartlett18, http://orcid.org/0000-0003-4837-9446Simon Knight8, Gavin Pettigrew2,10 1Department of Thoracic Surgery, University Hospitals Birmingham NHS Foundation...
The Creation of Video Palace — The Art of the Scare
Every day I commute, I cook, I do the dishes and I walk the dog. My eyes, my hands and my feet are engaged during these times but my brain, well, it’s not quite firing on all cylinders. I need more stimulation. That’s where podcasts come in. I slip on my headphones and boom… I’m multitasking like the thirty-something suburban ninja dad that I am. And, my fellow horror fans, the best kind of podcast for us who love to be afraid is hands down those of the scripted variety.
Implementation, not hesitation, for SGLT2 inhibition as foundational therapy for chronic kidney disease
In addition to the established cardiovascular benefits of SGLT2 inhibitors, the randomised data support their use for modifying risk of kidney disease progression and acute kidney injury, not only in patients with type 2 diabetes at high cardiovascular risk, but also in patients with chronic kidney disease or heart failure irrespective of diabetes status, primary kidney disease, or kidney function.
Authors’ Reply: Clinical Studies of Vaccine Efficacy
Thank you for your help in sharing the high-quality science in JASN. Your Email * Your Name * Send To * Enter multiple addresses on separate lines or separate them with commas. Message Subject (Your Name) has sent you a message from American Society of Nephrology Message Body (Your Name) thought you would like to see the American Society of Nephrology web site. CAPTCHA This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
A multisystem, cardio-renal investigation of post-COVID-19 illness - Nature Medicine
Abstract The pathophysiology and trajectory of post-Coronavirus Disease 2019 (COVID-19) syndrome is uncertain. To clarify multisystem involvement, we undertook a prospective cohort study including patients who had been hospitalized with COVID-19 (ClinicalTrials.gov ID NCT04403607).
Suggestions for Successful SGLT2i Use in Glomerular Disease
close Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Log out Cancel Abstract and Introduction Abstract Purpose of Review: Recent advances in the world of glomerular diseases have largely focussed on remission induction with immune modulating therapy.
Cystatin C Predicts Renal Disease and Cardiovascular Risk
Authors and Disclosures Jennifer S. Lees1,2 and Patrick B. Mark1,2 1Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK and 2Glasgow Renal and Transplant Unit, NHS Greater Glasgow and Clyde, Glasgow, UK Correspondence to Jennifer Lees; E-mail: Jennifer.lees@glasgow.ac.uk; Twitter handle: @jennifer_s_lees Conflict of Interest Statement This article has not been published previously, in whole or in part. There are no new data presented in this article.
Heart Failure Hospitalization in Adults Receiving Hemodialysis and the Effect of Intravenous Iron Therapy:
Abstract Objectives This study sought to examine the effect of intravenous iron on heart failure events in hemodialysis patients. Background Heart failure is a common and deadly complication in patients receiving hemodialysis and is difficult to diagnose and treat.
Glycated Hemoglobin, Prediabetes, and the Links to Cardiovascular Disease: Data From UK Biobank
Cardiovascular and Metabolic Risk Abstract OBJECTIVE HbA1c levels are increasingly measured in screening for diabetes; we investigated whether HbA1c may simultaneously improve cardiovascular disease (CVD) risk assessment, using QRISK3, American College of Cardiology/American Heart Association (ACC/AHA), and Systematic COronary Risk Evaluation (SCORE) scoring systems. RESEARCH DESIGN AND METHODS UK Biobank participants without baseline CVD or known diabetes (n = 357,833) were included.
Change in renal function associated with drug treatment in heart failure: national guidance
Change in renal function associated with drug treatment in heart failure: national guidance Authors Andrew L Clark Academic Cardiology, Hull York Medical School in the University of Hull, Hull, UK PubMed articlesGoogle scholar articles Paul R Kalra Department of Cardiology, Portsmouth Hospitals NHS Trust, Portsmouth, UK PubMed articlesGoogle scholar articles Mark C Petrie University of Glasgow Institute of Cardiovascular and Medical Sciences, Glasgow, UK Golden Jubilee National Hospital,...
Change in renal function associated with drug treatment in heart failure: national guidance
Change in renal function associated with drug treatment in heart failure: national guidance Andrew L Clark1, Paul R Kalra2, Mark C Petrie3,4, Patrick B Mark3, Laurie A Tomlinson5, Charles RV Tomson6 1 Academic Cardiology, Hull York Medical School in the University of Hull, Hull, UK 2 Department of Cardiology, Portsmouth Hospitals NHS Trust, Portsmouth, UK 3 University of Glasgow Institute of Cardiovascular and Medical Sciences, Glasgow, UK 4 Golden Jubilee National Hospital, Golden Jubilee...
Change in renal function associated with drug treatment in heart failure: national guidance
Change in renal function associated with drug treatment in heart failure: national guidance Andrew L Clark1, Paul R Kalra2, Mark C Petrie3,4, Patrick B Mark3, Laurie A Tomlinson5, Charles RV Tomson6 1 Academic Cardiology, Hull York Medical School in the University of Hull, Hull, UK 2 Department of Cardiology, Portsmouth Hospitals NHS Trust, Portsmouth, UK 3 University of Glasgow Institute of Cardiovascular and Medical Sciences, Glasgow, UK 4 Golden Jubilee National Hospital, Golden Jubilee...
Change in renal function associated with drug treatment in heart failure: national guidance
Change in renal function associated with drug treatment in heart failure: national guidance Andrew L Clark1, Paul R Kalra2, Mark C Petrie3,4, Patrick B Mark3, Laurie A Tomlinson5, Charles RV Tomson6 1 Academic Cardiology, Hull York Medical School in the University of Hull, Hull, UK 2 Department of Cardiology, Portsmouth Hospitals NHS Trust, Portsmouth, UK 3 University of Glasgow Institute of Cardiovascular and Medical Sciences, Glasgow, UK 4 Golden Jubilee National Hospital, Golden Jubilee...
Lipid management in patients with chronic kidney disease
Abstract An increased risk of cardiovascular disease, independent of conventional risk factors, is present even at minor levels of renal impairment and is highest in patients with end-stage renal disease (ESRD) requiring dialysis. Renal dysfunction changes the level, composition and quality of blood lipids in favour of a more atherogenic profile.
Management of lipids in adults with diabetes mellitus and nephropathy and/or chronic kidney disease: summary of joint guidance from the Association of British Clinical Diabetologists (ABCD) and the Renal Association (RA) | Mark | British Journal of Diabet
Uhlig K, Macleod A, Craig J, et al. Grading evidence and recommendations for clinical practice guidelines in nephrology. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 2006; 70:2058-65. http:dx.doi.org/10.1038/sj.ki.5001875 Barnett KN, Ogston SA, McMurdo ME, Morris Ad, Evans JM. A 12-year follow-up study of all-cause and cardiovascular mortality among 10,532 people newly diagnosed with type 2 diabetes in Tayside, Scotland. Diabet Med 2010;27:1124-9.
Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway
Background Hyperphosphataemia is an independent risk factor for accelerated cardiovascular disease in chronic kidney disease (CKD), although the mechanism for this is poorly understood. We investigated the effects of sustained exposure to a high-phosphate environment on endothelial function in cellular and preclinical models, as well as in human subjects.
Predictors of atherosclerotic events in patients on haemodialysis: post hoc analyses from the AURORA study
Background Patients on haemodialysis (HD) are at high risk for cardiovascular events, but heart failure and sudden death are more common than atherosclerotic events. The A Study to Evaluate the Use of Rosuvastatinin in Subjects on Regular Hemodialysis: An Assessment of Survival and Cardiovascular Events (AURORA) trial was designed to assess the effect of rosuvastatin on myocardial infarction and death from any cardiac cause in 2773 HD patients.
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