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Articles by Peter Croucher
Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease
Abstract Musculoskeletal diseases are a major health burden. Development of bone-active therapies has been hindered by limited understanding of the cells and genes that regulate the skeleton. We exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define the critical endosteal compartment that regulates bone turnover.
15 not-so-typical things to do in Moldova
Moldova, you say? It’s the kind of place that sneaks up on you — in the best way, of course. It’s not flashy. It doesn’t shout. But it does pour you a glass of homemade wine, invite you into ancient cave monasteries, and serve up dumplings that make you question everything you thought you knew about comfort food. This is a country where underground wine cities exist. Where the capital thrums with Soviet-era grit and charm in equal measure, and where every turn leads to a story you’ll want to tell.
Urban Rainbow Nation: best cities in South Africa
It's no wonder that South Africa is known as the Rainbow Nation — just look at its diverse array of cities, not to mention its safari parks and extensive winelands. With urban jungles rich in nature and architecture to coastal gems boasting rugged landscapes and captivating history, South Africa's cities provide the perfect backdrop for an adventure. Join us as we explore some of the unforgettable cities in South Africa, from Cape Town’s magnificent mountains to Kimberley’s monumental mines.
Macrophages direct location-dependent recall of B cell memory to vaccination
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Keywords memory vaccine germinal center plasma cells broadly neutralizing antibodies affinity maturation immune imprinting original antigenic sin SARS-CoV-2 subcapsular sinus macrophage Introduction Vaccines protect from recurrent infection and disease by inducing the secretion of neutralizing antibodies by long-lived plasma cells (PCs)1 and by generating memory B cells (Bmems).2 Long-lived PCs are terminally differentiated and can only secrete antibodies of fixed specificity and affinity for...
By Rama Dhenni, Arnold Reynaldi, Wunna Kyaw, Abigail K. Grootveld, Yuki Honda Keith, Nayan Bhattacharyya, Andrew McCorkindale, Seyhan Yazar, Christina Bui, James Smith, Weng Hua Khoo, Mollie Boyd, Brad Milner, Mitchell Starr, Fabienne Brilot, Vanessa Milogiannakis, Anouschka Akerman, Anupriya Aggarwal, Miles P Davenport, Elissa K. Deenick, Christine Chaffer, Peter Croucher, Robert Brink, Leonard D. Goldstein, Deborah Cromer, Stuart Turville, Anthony D. Kelleher, Vanessa Venturi, Tri Giang Phan, Alexandra Carey Hoppé, Nathalie Tricia Handoko, Holly I. Ahel, Aiden Josiah Telfser, Solange Obeid
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Cell Press
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Age-related mesenchymal stromal cell senescence is associated with progression from MGUS to multiple myeloma - Leukemia
Abstract The risk of progression of monoclonal gammopathy of undetermined significance (MGUS) to multiple myeloma (MM) increases with advancing age, suggesting that progression may be influenced by age-related changes within the bone marrow (BM) microenvironment. We hypothesise that senescent mesenchymal stromal cells (MSCs), which accumulate in the BM with age, may contribute to MGUS progression to MM.
A universal molecular control for DNA, mRNA and protein expression - Nature Communications
Abstract The expression of genes encompasses their transcription into mRNA followed by translation into protein. In recent years, next-generation sequencing and mass spectrometry methods have profiled DNA, RNA and protein abundance in cells. However, there are currently no reference standards that are compatible across these genomic, transcriptomic and proteomic methods, and provide an integrated measure of gene expression.
The dormant cancer cell life cycle - Nature Reviews Cancer
Lambert, A. W., Pattabiraman, D. R. & Weinberg, R. A. Emerging biological principles of metastasis. Cell 168, 670–691 (2017). CAS PubMed PubMed Central Google Scholar Dillekas, H., Rogers, M. S. & Straume, O. Are 90% of deaths from cancer caused by metastases? Cancer Med. 8, 5574–5576 (2019). PubMed PubMed Central Google Scholar Friberg, S. & Nystrom, A. Cancer metastases: early dissemination and late recurrences. Cancer Growth Metastasis 8, 43–49 (2015). PubMed PubMed Central Google Scholar Pan, H. et al.
Weather the storm
05Jun posted by: Peter Croucher of Weidmüller UK The 18th Edition of the IET Wiring Regulations (BS 7671), which came into full effect on 1st January 2019, significantly increases requirements for the provision of surge protection in electrical installations. Peter Croucher of Weidmüller UK examines the new requirements and discusses how to go about meeting them.
Help relieve the cost of Silvia's brain surgery
This campaign started on Nov 19 and will close on December 29, 2014 (11:59pm PT). This campaign will receive all funds raised even if it does not reach its goal.
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