Peter Winter
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Biotechnology writer and analyst; specializes in business and finance developments as well as precision medicine.
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Articles by Peter Winter
Agreement on expansion at Sandelford School...it could be childs play!
The council’s Rugby Avenue Playing Fields in Coleraine. | Supplied If agreement with the council is reached, the additional Rugby Avenue land would allow the EA to increase Sandelford’s capacity by around 100 pupils. A DEAL between the Council and the Education Authority to accommodate the expansion of Sandelford School may involve funding towards a “destination playpark” at the next door recreation grounds.
2026 Supercup NI generated over £10m for local economy
Supercup NI is one of Europe’s top youth football tournaments, say organisers. | Supplied Independent study reveals tournament’s economic impact. THE 2026 SupercupNI generated over £10m for Causeway Coast and Glens, according to organisers. The figure was revealed in a letter to the council seeking a meeting with officers and elected representatives to reflect on the success of July’s event and discuss “challenges” envisaged in 2027.
‘Free’ social housing need not be high-spec, says councillor
New social housing on Rathlin Island. | Chronicle Supplied Housing Executive confirms design guide is under review by central government HOUSEHOLDERS occupying social housing “for free” should be required to accept lower quality, mass built homes. That was one way of addressing the housing crisis afflicting Causeway Coast and Glens, suggested by a councillor last week.
Figures suggest booming tourism industry but MLA seeks for more help for businesses
Summer crowds on Portrush’s East Strand | Chronicle Supplied Figures show a significant increase in tourism but MLA is seeking additional support for local businesses to help them cope with the influx of visitors A TOTAL of 50 new tourism businesses were created in Causeway Coast and Glens between 2023 and 2025. And, according to figures released to the Assembly, tourists spent almost £600m on overnight trips to the borough during the same three-year period.
Asylum seekers are not impacting NIHE’s temporary housing portfolio
The Cromore Complex in Coleraine which has housed asylum seekers. | Chronicle Supplied Senior NIHE official questioned over the activities of Home Office contractors COMPETITION from asylum seekers is having no noticeable impact on the Housing Executive’s ability to secure temporary accommodation for locals.
Evaluating the role of pretraining dataset size and diversity on single-cell foundation model performance
Abstract The success of transformer-based foundation models on natural language and images has motivated their use in single-cell biology. Single-cell foundation models have been trained on increasingly larger transcriptomic datasets, scaling from initial studies with 1 million cells to newer atlases with over 100 million cells. Here we investigate the role of pretraining dataset size and diversity on the performance of single-cell foundation models on both zero-shot and fine-tuned tasks.
Improving atlas-scale single-cell annotation models with hierarchical cross-entropy loss
Abstract Accurately annotating cell types is essential for extracting biological insight from single-cell RNA sequencing data. Although cell types are naturally organized into hierarchical ontologies, most computational models do not explicitly incorporate this structure into their training objectives. Here, we introduce a hierarchical cross-entropy loss that aligns model objectives with biological structure.
Artificial variables help to avoid over-clustering in single-cell RNA sequencing
Keywords clustering double dipping single cell differential expression analysis calibration machine learning Get full text access Log in, subscribe or purchase for full access. References 1. Zheng, G.X.Y. ∙ Terry, J.M. ∙ Belgrader, P. ... Massively parallel digital transcriptional profiling of single cells Nat. Commun. 2017; 8, 14049 2. Macosko, E.Z. ∙ Basu, A. ∙ Satija, R. ... Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets Cell. 2015; 161:1202-1214 3.
Adapting systems biology to address the complexity of human disease in the single-cell era - Nature Reviews Genetics
Abstract Systems biology aims to achieve holistic insights into the molecular workings of cellular systems through iterative loops of measurement, analysis and perturbation. This framework has had remarkable success in unicellular model organisms, and recent experimental and computational advances — from single-cell and spatial profiling to CRISPR genome editing and machine learning — have raised the exciting possibility of leveraging such strategies to prevent, diagnose and treat human diseases.
Drones could revolutionize the construction industry, supporting a new UK housing boom
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Drones could revolutionize the construction industry, supporting a new UK housing boom
The UK's new Labor government has pledged to build 1.5 million homes during its first term in office. To achieve this, it promises planning reform and the reintroduction of local housing targets. Yet little attention has been given to the role of new technologies. Drones have the potential to transform the construction industry in the UK.
Drones could revolutionise the construction industry, supporting a new UK housing boom Original
The UK’s new Labour government has pledged to build 1.5 million homes during its first term in office. To achieve this, it promises planning reform and the reintroduction of local housing targets. Yet little attention has been given to the role of new technologies. Drones have the potential to transform the construction industry in the UK.
Kenbane Castle named as Red Bull Cliff Diving event venue
THE rugged coastline around Kenbane Castle is set to become one of the venues for the Red Bull’s Cliff Diving World Series when it visits the North Coast later this month. Ballycastle is playing host to the international event on the weekend of July 18-20. While the athleteswill compete in the final two rounds by diving from the purpose-built platforms built in Ballycastle Harbour, Red Bull has promised preliminary rounds directly off cliffs.
Mutation and cell state compatibility is required and targetable in Ph+ acute lymphoblastic leukemia minimal residual disease
Abstract Efforts to cure BCR::ABL1 B cell acute lymphoblastic leukemia (Ph+ ALL) solely through inhibition of ABL1 kinase activity have thus far been insufficient despite the availability of tyrosine kinase inhibitors (TKIs) with broad activity against resistance mutants. The mechanisms that drive persistence within minimal residual disease (MRD) remain poorly understood and therefore untargeted.
Council hopes for litter blight ‘game-changer’
A SENIOR council official has described a scheme that allows the public to exchange empty plastic bottles for cash as “an absolute game changer.” Environmental Services Chief Aidan McPeake was speaking during a debate on litter blight at North Coast beauty spots. The Deposit Return Scheme was introduced in the Republic in February and environment official here say plans are underway for similar arrangements.
Dog attacks at local beach have left residents ‘scared stiff’
OUT of control dogs have made local people too scared to walk on Waterfoot beach, a councillor has warned. The claim was made by SDLP Deputy Mayor Margaret Anne McKillop during a meeting of the council’s Environmental Services Committee last month. She said one incident had already prompted likely police intervention. And she called for stepped-up patrols and more clarity around the council’s policy on dog control at North Coast beaches.
East Strand chosen as D-day beacon venue
A BEACON will be lit on Portrush’s East Strand to mark the 80th anniversary of the D-Day landings, according to plans approved by a council committee this week. The event on June 6 will be attended by County Antrim Deputy Lord Lieutenant Stephen Bailie and the band of the 152 Royal Logistics Corp. Also invited are Royal British Legion groups from around the borough. Dr Bailie is retired from HM Forces after 38 years having served in the Regular and Reserve Forces.
Planners give nod to local firm’s £10m expansion plan
PLANNERS have recommended approving the proposed expansion of a local factory which should provide a signification boost to Coleraine’s economy. When it was lodged after a public consultation in 2021, applicant Maine Surface Finishing said it could create 150 new jobs at its Wattstown plant. The 13 acre site will house new fabrication, assembly and R&D facilities plus a ‘landmark’ office block building.
Portstewart beach protest
DOZENS of campaigners turned out at a North Coast beach on Saturday to protest over a lost access route. They say local people have been accessing Bailey’s Beach (also known as the wee beach) in Portstewart along a path form the Strand Road for decades. Last year it was bulldozed and blocked off by electronically controlled gates. Since then a group of residents have been urging Causeway Coast and Glens Council to take action.
Council to take back control of skaters’ square
THE council should take full responsibility for a town square that has become a ‘mecca’ for skateboarders from across the North Coast, elected members have agreed. In October 2022 councillors approved the creation of a temporary designated space at Station Square, Portrush for skateboarding. Though public liability insurance was provided by ratepayers, responsibility for maintaining equipment and health and safety issues was handed to a ‘working group’ via a memorandum of understanding.
Zoned out!
COLERAINE is to lose its unique status as Northern Ireland’s only Enterprise Zone, the Chronicle can reveal. Described as “ a significant economic development opportunity” when the designation was handed down by the UK Treasury in 2016, enterprise zones offered tax breaks to encourage private sector investment. It was conferred on Coleraine in 2016 and was widely seen as compensation for losing hundreds of Driver and Vehicle Agency jobs. But the designation is due to expire on March 16.
Renting a home on North Coast now ‘almost impossible’
NORTH Coast locals are finding it almost impossible to secure a long-term rented home while the number of houses being offered as short-term holiday lets is continuing to grow. That’s what members of Causeway Coast and Glens Borough Council heard when concerns over the sector’s impact on coastal communities were raised with Tourism NI’s Chief Executive.
Tributes to late Queen considered
THE renaming of Castlerock’s Promenade and installing a depiction of the Queen meeting Paddington Bear are among suggested tributes by councillors local to the late monarch.
Dark times at the Dark Hedges
COUNCILLORS have been told that 11 of the famous trees that make up the Dark Hedges should be cut down. A tree expert’s report commissioned by roads officials has concluded that they have become dangerously unstable. However, because six are protected by Tree Preservation Orders, (TPOs) council consent for their removal is required. The request will be put to members of Cloonavin’s Planning Committee this week, along with plans to manage the remaining trees.
AERoS: Assurance of Emergent Behaviour in Autonomous Robotic Swarms
Abstract The behaviours of a swarm are not explicitly engineered. Instead, they are an emergent consequence of the interactions of individual agents with each other and their environment. This emergent functionality poses a challenge to safety assurance. The main contribution of this paper is a process for the safety assurance of emergent behaviour in autonomous robotic swarms called AERoS, following the guidance on the Assurance of Machine Learning for use in Autonomous Systems (AMLAS).
Girona artwork to be ‘focal point’ for Spanish and local visitors
A PUBLIC art installation commemorating the wreck of La Girona should provide a focal point for history buffs and Spanish visitors keen to explore the legacy of the Armada. It’s thought that around 1400 seamen were lost when the ship foundered off Lacada point close to the Giant's Causeway in 1588.
Councillors to debate ‘action plan’ for blue green algae
COUNCILLORS are to address the threat of Blue Green Algae when they meet for their first significant debate after the summer break. Algae blooms originating in Lough Neagh but carried to the North Coast by the River Bann effectively closed beaches on two occasions in July and August. Now an Alliance Party councillor is seeking support for measures aimed at preventing a re-occurrence. Peter McCully has tabled a motion that fellow councillors are due to debate tonight (Tuesday, September 5).
Sensors | Free Full-Text | Using the Non-Adoption, Abandonment, Scale-Up, Spread, and Sustainability (NASSS) Framework to Identify Barriers and Facilitators for the Implementation of Digital Twins in Cardiovascular Medicine
Desirability Table 3 is the third of the seven domains: the value proposition. The NHS healthcare system is confronted with a constant rise in demand to diagnose and treat people with symptoms of cardiovascular diseases which is estimated to cost the NHS and wider society in England £15.8 billion a year [26]. This means that there is an immediate requirement to maximise the efficiency of healthcare services but at the same time minimise costs.
Officials advise against plans for outdoor drinking at Harbour Bar
ROADS officials have refused to endorse plans for a pavement terrace outside one of the Northern Ireland’s most popular pubs. The Harbour Bar’s application to install outdoor seating was considered by members of the council’s Environmental Services Committee on Tuesday evening. However, members were told the Department of Infrastructure would not be approving a Pavement Cafe Licence because seating would not leave enough space for pedestrians, particularly those with disabilities.
Laurel Park residents in renewed battle over social housing scheme
COLERAINE residents, opposed to plans for a social housing scheme on their doorstep, suffered a blow this week when developers formally indicated a planning application was due. Last year councillors authorised a sell-off of the nine-acre site at Laurel Hill to Northern Ireland’s biggest housing association. Until now there has been no planning application for housing and so neighbours have instead focused on access road plans lodged in August 2022.
The Coleraine bomb - half century of hurt
THE Mayor of Causeway Coast and Glens said he was honoured to unveil a memorial to the six people killed by the Coleraine bomb exactly 50 years ago. Councillor Steven Callaghan was speaking after hosting an Act of Remembrance service on Monday, June 12, which began with a minute’s silence at 3pm – the time on June 12, 1973 when an IRA device detonated in Railway Road. The permanent memorial now standing outside Coleraine Town Hall was installed over the weekend and dedicated to the six victims.
Pooling resources: Statistics, swimming and why winners don’t always finish first
Aquestion raised in many different situations in sport, including swimming, is that of how we can ensure that winning is determined only by sporting factors such as skill, fitness, power, endurance, tactical ability and mental focus. How can we ensure this is the case when considering athletes of all ages, including those with disability classifications?
Maritime tragedy memorial to be unveiled
A MEMORIAL is to be unveiled 100 years after a maritime tragedy that took the lives of three Portstewart men. It was a Saturday morning on January 6, 1923 when three men drowned trying to reach a ship bound for Coleraine. James Doherty (60) and Alexander Millar (40) were pilots employed by Coleraine Harbour Commission to steer craft over the treacherous Bar mouth. The two highly experienced seafarers were accompanied by James's son, 18-year-old Harry Doherty, when disaster struck.
‘Hotel on course’
DEVELOPERS behind the Merrow Hotel and Spa proposal have reaffirmed their commitment to the project. Vivienne Gilholm, Director of C&V Developments, said a re-submitted planing application was at an advanced stage. “We have encountered setbacks along the way, but we still believe this is a special project that will bring so much to the Causeway area and we’re committed to making it a reality so it can be enjoyed by locals and visitors from around the world.
Downhill mausoleum in ‘ruinous state’
A 250-year-old mausoleum in Downhill Demesne has deteriorated to ‘a ruinous state,’ according to the National Trust. Details abut the condition of the historic monument are revealed in a planning application lodged by the charity for ‘priority repairs.’ “The proposed priority works look to consolidate the most deteriorated/defective areas of the Mausoleum,” state documents accompanying the application say. For the full story see this week's Chronicle.
Council input over abortion clinic safe zone?
NORTHERN Ireland’s top health official has written to Causeway Coast and Glens Council ahead of possible engagement over the establishment of safe zones around clinics providing abortion services. The letter was prompted by a Supreme Court ruling that paved the way for a new law passed by Northern Ireland's Assembly. The judges ruled the Abortion Services (Safe Access Zones) Act (Northern Ireland) 2023 was indeed compatible with Human Rights legislation.
Ja spinnen die denn, die Myonen?
Zusammenfassung Das Myon-g-2-Experiment am Fermilab hat eine Abweichung des anomalen magnetischen Moments des Myons von der theoretischen Vorhersage gemessen, die nun zusammen mit dem Resultat des Brookhaven National Laboratory auf mehr als vier Sigma gestiegen ist – ein spannender Hinweis auf Physik jenseits des Standardmodells.
A bigger bang?
A HALLOWEEN extravaganza for up to 20,000 spectators has been proposed for Coleraine. The idea of merging the borough’s four displays into one ‘high quality event’ was tabled by council officers at last week's Leisure and Development Committee meeting. Though members recommended sticking to the current four-venue format, a final decision will only be made when the full council meets next month. Last year’s displays in Ballymoney Ballycastle, Limavady and Coleraine cost ratepayers just over £75,000.
Medical artificial intelligence is as much social as it is technological - Nature Machine Intelligence
Despite the promise of medical artificial intelligence applications, their acceptance in real-world clinical settings is low, with lack of transparency and trust being barriers that need to be overcome. We discuss the importance of the collaborative process in medical artificial intelligence, whereby experts from various fields work together and tackle transparency issues and build trust over time.
Feeling down about Levelling Up!
QUESTIONS have been raised over East Londonderry’s exclusion from the latest round of Levelling-up funding. Three projects in neighbouring County Antrim received more than £16m between them while two flagship schemes in Coleraine were ignored. Mid Ulster's £9m bid for new green space and recreational facilities in Maghera was also successful.
‘If You’re Going to Trust the Machine, Then That Trust Has Got to Be Based on Something’:
Abstract The role of Artificial Intelligence (AI) in clinical decision-making raises issues of trust. One issue concerns the conditions of trusting the AI which tends to be based on validation. However, little attention has been given to how validation is formed, how comparisons come to be accepted, and how AI algorithms are trusted in decision-making.
Bomb memorial plans slammed
By Peter Winter THE son of a woman killed by the Railway Road bomb will not be at the unveiling of a memorial plaque thanks to the council's handling of the event, his family has claimed. Nan Davis was one of six people murdered by the IRA in 1973. According to granddaughter Lesley Magee, victims' families were given just a few days notice ahead a low key unveiling ceremony scheduled for today, Wednesday June 1.
Waste Management NZ back in Aussie hands
Chinese owners of one of the country’s largest rubbish disposal companies, Waste Management NZ, have sold the business to Australian-based Igneo Infrastructure Partners.The $1.9 billion transaction means Beijing Capital Group has doubled its money in eight years as owner.Igneo is a part of the First Sentier Investors group, which is headquartered in Sydney and holds investments throughout Europe and the United Kingdom, North America, Australia, and in New Zealand.In NZ, it also owns gas...
This is a Stick-Up
Back when I was a kid running around New York pretending to know a whole lot more than I did, I consulted to News Corporation. Well, okay, to Rupert Murdoch himself. Often over a beer on a Friday night, I found myself listening with rapt attention as people who had worked with him for years exchanged stories about his misadventures. To us, he walked on water.
Equity Analysts with 100% Return Predictions in 2021: 5 Picks 5 Home Runs
These 5 equity analysts made brilliant stock recommendations that returned over 100% to the investors that followed their advice in 2021. These portfolio picks are the result of deep analysis of often overlooked stocks in a variety of industry sectors. The stock recommendations of Perficient, Inc.
Microenvironment drives cell state, plasticity, and drug response in pancreatic cancer
Highlights • scRNA-seq of metastatic pancreatic cancer and matched organoid models • Ex vivo to in vivo comparisons reveal loss of cell state heterogeneity in models • Cell state is shaped by the microenvironment in vivo and can be controlled ex vivo • Cell state drives drug response Summary Prognostically relevant RNA expression states exist in pancreatic ductal adenocarcinoma (PDAC), but our understanding of their drivers, stability, and relationship to therapeutic response is limited.
The Artist Who Runs the Georgetown Dump
This portrait of the Flemings is as much a portrait of the season and their surroundings, with layer upon layer of detail. Photo by Peter Winter Artist Jim Coombs also works at the Georgetown Transfer Station. Photo by Desmond MacRaeEVER SINCE the railroad came to Maine in the early 1900s, artists have flocked to the island of Georgetown, 10 miles south of Bath. The painters Marsden Hartley and Dahlov Ipcar and the sculptors Gaston Lachaise and William Zorach all lived and worked on the island.
A green light for AD therapy could give sector a major boost
Public biopharmaceutical companies did manage to attract some investors off the sidelines in May with medical conference season getting into full gear. However, it was generally another lackluster month, with the Nasdaq Biotech index dropping 2% in the period in contrast to the broader markets with the Dow Jones Industrial Average growing by 2%. The sector, however, could get a significant boost in the next few days if the FDA gives the green light to Biogen Inc.
COVID-19 R&D drives sector’s research spending in Q1
The top 100 public biopharmaceutical companies with market caps greater than $1 billion, and excluding big pharma companies, spent a total of almost $12 billion on R&D in the first quarter of 2021, compared to $9.4 billion invested last year. A BioWorld analysis of the quarterly filings of this group found that the 24% year-over-year increase in spending was driven, in part, by companies involved in developing COVID-19 vaccines and therapeutics.
Markets tough on cancer-focused biopharmas
The articles in this collection are from BioWorld’s ongoing coverage of the COVID-19 coronavirus outbreak. Note that we have added three critical tables which are...
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