Philip Smallwood on Muck Rack

Philip Smallwood

Austin
As seen in: PNAS, Cell Press, Blavity, London Review of Books, eLife, The Journal of Biological Chemistry, LEDs Magazine, Strategies Unlimited
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Articles

Enhancers that direct gene expression to central nervous system vascular endothelial cells in vivo

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By Zhongming Li, Amir Rattner, YanShu Wang, Philip Smallwood, Mark F. Sabbagh, Brandon J. Mannion, Len A. Pennacchio, Jeremy Nathans
| Cell Press Verified
The ability of the rAAV platform to reveal enhancer activity of JN11 and its derivatives suggested that a large-scale rAAV library of genomic segments with candidate CREs could be used to screen for EC CRE activity.
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Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

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By YanShu Wang, Amir Rattner, Zhongming Li, Philip Smallwood
| eLife
eLife Assessment Endothelial cell-specific loss of TGF-beta signaling in mice leads to CNS vascular defects, specifically impairing retinal development and promoting immune cell infiltration. The data are solid, showing that loss of TGF-beta signaling triggers vascular inflammation and attracts immune cells specific to CNS vasculature.
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Vascular endothelial-specific loss of TGF-beta signaling as a model for choroidal neovascularization and central nervous system vascular inflammation

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By YanShu Wang, Amir Rattner, Zhongming Li, Philip Smallwood
| biorxiv.org
Abstract In mice, postnatal endothelial cell (EC)-specific knockout of the genes coding for Transforming Growth Factor-Beta Receptor (TGFBR)1 and/or TGFBR2 eliminates TGF-beta signaling in vascular ECs and leads to distinctive central nervous system (CNS) vascular phenotypes.
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