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Pierre Close

As seen in: Nature, Cell Press
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Articles by Pierre Close

Pan-cancer single-cell atlases of mouse and human tumor-associated dendritic cells

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By Aarushi A. Caro, Daliya Kancheva, Eva Hadadi, Bram Boeckx, Clint De Nolf, Pauline M. R. Bardet, Kevin Verstaen, Luqing Li, Nil Figueras-Duch, Niels Vandamme, Sofie Deschoemaeker, Arnaud Blomme, Pierre Close, Sophie Janssens, Michele De Palma, Diether Lambrechts, An Coosemans, Damya Laoui, Lobna Oueslati, Yvon Elkrim
| Nature Verified
Abstract Dendritic cells (DCs) are critical inducers of anti-tumor immunity. To achieve a comprehensive mapping of mouse and human DC subsets and states in a cancer context, here we generate pan-cancer mouse and human tumor-associated DC (TADC) scRNA-seq atlases, encompassing 14 mouse tumor models and 10 human cancer types, within which we identify several lineage-defined DC subsets along with maturation/functional states.
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Multiomics immune profiling of a patient-relevant orthotopic lung cancer model using SEPARATE-Seq

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By Lize Allonsius, Eva Hadadi, Daliya Kancheva, Morgane Paque, Ayla Debraekeleer, Ria Roelandt, Kevin Verstaen, Delphine Hoton, Louis Boon, Arnaud Blomme, Sofie Deschoemaeker, Geert Raes, Elly Marcq, Jan P. Böttcher, Jitka Fucikova, Pierre Close, Frank Aboubakar Nana, Damya Laoui, Pauline M. R. Bardet, Sarka Vosahlikova, Aarushi A. Caro, Anouk Van Audenhove, Michal Hensler, Gisèle Mateu Cabrera, Ahmed E. I. Hamouda
| Nature Verified
Abstract Relevant pre-clinical models are essential for driving progress in cancer therapy research. Here, we develop a pre-clinical study framework using an injectable orthotopic lung adenocarcinoma (LUAD) model (ORTHO) that replicates key features of human LUAD patients and is dissectible into tumoural and non-tumoural adjacent tissue, in analogy with patient samples.
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Disruption of tRNA threonylation triggers RIG-I mediated anti-tumour immune response - Nature Communications

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By Christian Seca, Coralie Capron, Chloé Maurizy, Ning An, Timothy Budden, Lorena Martin-Morales, Miguel Ruiz, Najla El-Hachem, Raphael Vanleyssem, Marine Leclercq, Arnaud Blomme, Alain Chariot, Jochen S. Utikal, Amaya Viros, Francesca Rapino, Sylvain Delaunay, Pierre Close, Cléa Dziagwa, Denis Heusdens, Elodie Renaude
| Nature Verified
Abstract Tumour-induced mechanisms of immune evasion hinder immune response to cancer, particularly in melanoma. mRNA translation, by ensuring accurate protein synthesis, regulates cancer phenotypes and immune response, but the underlying mechanisms remain unclear.
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HLA export by melanoma cells decoys cytotoxic T cells to promote immune evasion

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By Yoav Chemla, Orit Itzhaki, Stav Melamed, Chen Weller, Yuval Sade, Paulee Manich, Keren Reshef, Nicolas Xenidis, Avishai Maliah, Gilad Levy, Roma Parikh, Osnat Bartok, Itay Tal, Gal Aziel, Abraham Nissani, Sharon Yunger, Daniela Likonen, Tamar Golan, Coralie Capron, Ronen Levy, Diana Rasoulouniriana, Zohar Eyal, Yuval Barzilay, Aseel Khateeb, Tamar Ziv, Polina Greenberg, Xunwei Wu, Yael Amitay, Dov Hershkovitz, Tal Yardeni, Valentina Zemser-Werner, Oren Kobiler, David Bassan, Ron Shamir, Nadine Santana-Magal, Michael Milyavsky, Galit Eisenberg, Leeat Keren, Merav Cohen, Dvir Gur, Boaz Barak, Michal Lotem, David Sprinzak, Shoshana Greenberger, David Fisher, Michal J. Besser, Mehdi Khaled, Pierre Close, Ronnie Shapira, Sebastien Apcher, Asaf Madi, Mitchell Levesque, Yaron Carmi, Shivang Parikh, Yardena Samuels, Carmit Levy, Vitaly Kliminsky, Valentina Ace, Roi Balaban, Rami Khosravi, Amir Grau, Dvir Netanely, Hananya Vaknin, Ronen Brenner, Yael Friedmann, Lea Eisenbach, Francessca Rapino
| Cell Press Verified
STAR★Methods REAGENT or RESOURCESOURCEIDENTIFIER Antibodies 112Cd Rat Anti mouse CD45 BioLegend Clone:30-F11; Cat#103120; RRID: AB_312985 113In anti-mouse/human CD44 BioLegend Clone:IM7; Cat#103014; RRID: AB_312965 115In Rat anti-mouse CD3 BioLegend Clone: 145-2C11; Cat#100340; RRID: AB_11149115 141Pr Rat anti-mouse CD274 BioLegend Clone:10F.9G2; Cat#124302; RRID: AB_961228 142Nd Ratr anti-mouse Ly-6G/Ly-6C (Gr-1) BioLegend Clone: RB6-8C5; Cat#108449; RRID: AB_2563785 143Nd Ratr anti-mouse...
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Upregulation of ELP3 in acinar cells during acute pancreatitis is dispensable for homeostasis, inflammation, regeneration, and cancer initiation - Scientific Reports

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By Marine Leclercq, Sahar Nissim, Laurent Nguyen, Alain Chariot, Patrick Henriet, Donatienne Tyteca, Pierre Close, Elias Aajja, Hélène Lefort
| Nature Verified
Abstract Pancreatitis, or inflammation of the pancreas, is a common gastrointestinal condition. While often acute and self-resolving, it can become chronic and promote pancreatic ductal adenocarcinoma (PDAC), the third deadliest cancer worldwide. Pancreatitis is accompanied by morphological and molecular changes, notably immune cell infiltration, fibrosis, and acinar-to-ductal metaplasia (ADM).
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The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage

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By Pierre Close, Kateryna Shostak, Zheshen Jiang, Benoit Charloteaux
| Nature Verified
Abstract Prolonged cell survival occurs through the expression of specific protein isoforms generated by alternate splicing of mRNA precursors in cancer cells. How alternate splicing regulates tumor development and resistance to targeted therapies in cancer remain poorly understood. Here we show that RNF113A, whose loss-of-function causes the X-linked trichothiodystrophy, is overexpressed in lung cancer and protects from Cisplatin-dependent cell death.
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