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Articles by Ping Ren
Functional and structural basis of Omicron BA.3.2.1 spike
ArticleVolume 45, Issue 8117812Open access Affiliations & Notes 1Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, United States of America 2Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, United States of America 3Department of Pathology, University of Texas Medical Branch, Galveston, TX, United States of America 4Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX,...
A novel CDK8/19 inhibitor RO8323 mitigates allograft rejection through dual mechanisms of action to modulate regulatory T cell and myeloid cell
Abstract Regulatory T (Treg) cells are pivotal in maintaining immune homeostasis through suppression of effector T (Teff) cells, making their therapeutic modulation a promising strategy for treating autoimmune and inflammatory diseases. CDK8/19 inhibitors promote Treg cell differentiation by upregulating Foxp3 expression in both naive and memory/effector T cells.
Vaginal lavage fluid can serve as a reliable method for early screening of endometrial cancer: a proof-of-concept study
Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China Background: Endometrial cancer (EC) is one of the malignant tumors in the female reproductive system, and effective screening is urgently needed to reduce mortality. At present, the main screening method for endometrial cancer is ultrasound combined with curettage and pathological examination.
Spatiotemporal Evolution and Suitability Evaluation of Rural Settlements in the Typical Mountainous Area of the Upper Minjiang River: A Case Study of Lixian County, Sichuan Province, China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Trends in Antifungal Resistance Among Candida Species: An Eight-Year Retrospective Study in the Galveston-Houston Gulf Coast Region
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Optimizing Provider Test Ordering and Patient Outcomes Through Best Practice Alerts and Doctorate in Clinical Laboratory Sciences (DCLS) Consultation for Urine Cultures
1. Introduction Concerns regarding the emergence of antibiotic-resistant organisms remain at the forefront of the healthcare industry. The Centers for Disease Control and Prevention (CDC) has labeled it as a global threat, stating that more than 2.8 million antibiotic-resistant infections occur in the US each year, and more than 35,000 people die as a result [1].
Study on the Evolution of the Mountain Ecological Environment Based on Remote Sensing and Water Footprints: Case Study of Northwestern Sichuan, Southwest China
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Sensitive detection of synthetic response to cancer immunotherapy driven by gene paralog pairs
Abstract Emerging immunotherapies such as immune checkpoint blockade (ICB) and chimeric antigen receptor T-cell (CAR-T) therapy have revolutionized cancer treatment and have improved the survival of patients with multiple cancer types. Despite this success many patients are unresponsive to these treatments or relapse following treatment.
Ultra-stretchable and high performance fibrous TENG with helically structured dual-channel Liquid Metal electrode
Owing to the increasing environmental pollution and extreme shortage of resource, energy crisis [1] has become a global problem for mankind. Harvesting clean, sustainable energy from the environment is an effective and necessary solution [2], [3], [4], [5].
Pharmaceutics | Free Full-Text | Effect of the Similarity of Formulations and Excipients of Approved Generic Drug Products on In Vivo Bioequivalence for Putative Biopharmaceutics Classification System Class III Drugs
4. Discussion In the present study, 16 putative BCS Class III drug substances were chosen as the model drugs to explore the impact of the similarity of formulations and excipients on in vivo absorption of those drugs in human from 133 approved ANDAs with different IR solid oral-dosage forms. Each drug absorption was assessed by AUC0-t, AUC0-inf, and Cmax in the single dose in vivo BE studies with PK endpoints under the fasting and fed states or fasting only condition in healthy subjects.
The protective effect of Nostoc commune Vauch. polysaccharide on alcohol‐induced acute alcoholic liver disease and gut microbiota disturbance in mice
Background In recent years, the incidence of alcoholic liver disease (ALD) has gradually increased, the development of ALD is attached great attentions. Nostoc commune Vauch. polysaccharide (NCVP) is beneficial to maintain the gut health, but the protective effect of NCVP on the liver has not been reported yet. Purpose To study the protective effect and the underlying mechanisms of NCVP on ALD, a mouse model of acute ALD was established.
New form of addiction: An emerging hazardous addiction problem of milk tea among youths
Milk tea has gained worldwide popularity in the recent years (Wu, 2020). It refers to an umbrella term encompassing all beverages sold in milk tea shops, such as milk tea, fruit tea, floral tea, bubble tea, and others. This inclusive definition is based on the emerging trend of combining ‘milk tea + other tea drinks’ in the present Chinese milk tea market, gradually becoming mainstream (Shi et al., 2021; Zhao et al., 2021).
Is teacher preference associated with aggressive behavior among Chinese adolescents: The mediating role of peer rejection and rejection sensitivity
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. The data sets generated and analyzed during the current study are not publicly available but are available from the corresponding author on reasonable request.
Sustainability | Free Full-Text | Research on Welfare Changes of Farmers with Different Livelihood Assets after Rural Residential Land Exit in the Context of “Tripartite Entitlement System”: A Case Study of Fuhong Town in Qingbaijiang District
This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
RAMIHM generates fully human monoclonal antibodies by rapid mRNA immunization of humanized mice and BCR-seq
Method details Rapid mRNA immunization of humanized mice The full-length Omicron spike sequence used in mRNA immunization was based on two North American patients identified on Nov23rd, 2021. The LNP-mRNA was generated as previously described. 11 Fang Z. Peng L. Filler R. Suzuki K. McNamara A. Lin Q. Renauer P.A. Yang L. Menasche B. Sanchez A. et al. Omicron-specific mRNA vaccination alone and as a heterologous booster against SARS-CoV-2.
The Role of PPARs in Breast Cancer
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessReview by Binggong Zhao 1,†, Zhiqiang Xin 2,†, Ping Ren 2,* and Huijian Wu 1,* 1 Key Laboratory of Protein Modification and Disease, School of Bioengineering, Dalian University of Technology, Dalian 116024, China 2 Hospital Office, The Second Hospital of Dalian Medical University, Dalian 116023, China * Authors to whom correspondence should be addressed.
Low neutralization of SARS-CoV-2 Omicron BA.2.75.2, BQ.1.1 and XBB.1 by parental mRNA vaccine or a BA.5 bivalent booster - Nature Medicine
Ethics statement All virus work was performed in a BSL-3 laboratory with redundant fans in the biosafety cabinets at The University of Texas Medical Branch (UTMB) at Galveston. All personnel wore powered air-purifying respirators (Breathe Easy, 3M) with Tyvek suits, aprons, booties and double gloves. The research protocol regarding the use of human serum specimens was reviewed and approved by the UTMB institutional review board (IRB) (no. 20-0070).
Publisher Correction: A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions - Nature Communications
Correction to: Nature Communications https://doi.org/10.1038/s41467-022-31930-z, published online 27 July 2022 The original version of this Article contained an error in Fig. 3h, in which the numbers indicating days of infection and sample collection were incorrectly placed along the timeline. This has been corrected in both the PDF and HTML versions of the Article. Author information Author notes These authors contributed equally: Yang Liu, Xianwen Zhang, Jianying Liu, Hongjie Xia.
Neutralization of SARS-CoV-2 Omicron sublineages by 4 doses of mRNA vaccine
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A live-attenuated SARS-CoV-2 vaccine candidate with accessory protein deletions - Nature Communications
Abstract We report a live-attenuated SARS-CoV-2 vaccine candidate with (i) re-engineered viral transcription regulator sequences and (ii) deleted open-reading-frames (ORF) 3, 6, 7, and 8 (∆3678). The ∆3678 virus replicates about 7,500-fold lower than wild-type SARS-CoV-2 on primary human airway cultures, but restores its replication on interferon-deficient Vero-E6 cells that are approved for vaccine production. The ∆3678 virus is highly attenuated in both hamster and K18-hACE2 mouse models.
Highly sensitive and selective surface plasmon resonance biosensor for detection of SARS-CoV-2 spike S1 protein
Highly sensitive and selective surface plasmon resonance biosensor for detection of SARS-CoV-2 spike S1 protein Qiong Wu, Wen Wu, Fangfang Chen and Ping Ren Abstract The reality that the coronavirus disease 2019 (COVID-19) is still raging around the world and making a comeback with a strong posture has highlighted the need for rapid and sensitive quantitative detection methods of viral RNA, antibody and antigen for widespread tracking and screening applications.
Diffusion Tensor Imaging Revealed Microstructural Changes in Normal-Appearing White Matter Regions in Relapsing-Remitting Multiple Sclerosis
Introduction Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS). Two hundred million people have been suffering from multiple physical and psychological symptoms caused by MS (Hauser and Cree, 2020). The clinical symptoms of MS include limb weakness, sensory disorder, blurred vision, cognitive impairment, and dizziness, which may significantly impair the quality of life in people with MS (Filippi et al., 2020).
Novus Research shows Discrepancies in Amino Acid Recommended Requirements under Antibiotic-Free Swine diets
New research from Novus International, Inc. shows that swine producers operating without antibiotics in diets may be using the wrong ratio of amino acids in their feed formulations. The research, published in Volume 11, Issue 11 of the peer-reviewed journal Animals, looks at how additive amounts in antibiotic-free (ABF) diets differ from some recommendations listed in the National Research Council’s (NRC) nutrient requirement standards.
Author Correction: A high-throughput neutralizing antibody assay for COVID-19 diagnosis and vaccine evaluation
Correction to: Nature Communications https://doi.org/10.1038/s41467-020-17892-0, published online 13 August 2020. The original version of this Article contained an error in the Acknowledgements, which incorrectly listed the NIH grant ‘AI142759’. This has been corrected in both the PDF and HTML versions of the Article. Author information Author notes These authors contributed equally: Antonio E. Muruato, Camila R.
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis - Nature
No statistical methods were used to predetermine sample size. The experiments were not randomized, and investigators were not blinded to allocation during experiments and outcome assessment.
Establishing In Situ Closed Circuit Perfusion of Lower Abdominal Organs and Hind Limbs in Mice
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Efficacy of copper-impregnated hospital linen in reducing healthcare-associated infections: A systematic review and meta-analysis
Loading metrics Open Access Peer-reviewed Research Article Tingting Fan, Li Shao, Xingzhen Wang, Ping Ren Tingting Fan, Li Shao, Xingzhen Wang, Ping Ren Published: July 20, 2020 https://doi.org/10.1371/journal.pone.0236184 Figures Abstract Background Healthcare-associated infections (HAI) are a significant burden on the healthcare system. Recent research has suggested the role of copper in reducing HAI.
linking academia, business and industry through research
Home Full-text access for editors A new mobile opportunity perception network strategy and reliability research in coal mine by Ping Ren; Jingzhao Li; Dayu Yang International Journal of Embedded Systems (IJES), Vol. 12, No. 3, 2020 Abstract: Aiming at the advantages of internet of things in coal mine application, in this paper, we propose a new method of mobile opportunity perception, which makes full use of underground mine mobile resources.
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