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Articles by Ping Ye
Tension reduction from inter-membrane counter-deformation accelerates nuclear electroporation
Loading metrics Open Access Peer-reviewed Research Article Citation: Diao Y, Ye P, Liu B (2026) Tension reduction from inter-membrane counter-deformation accelerates nuclear electroporation. PLoS One 21(10): e0361048. https://doi.org/10.1371/journal.pone.0361048 Editor: Massimo Mariello, University of Oxford, UNITED KINGDOM OF GREAT BRITAIN AND NORTHERN IRELAND Received: September 27, 2025; Accepted: October 5, 2026; Published: October 23, 2026 Copyright: © 2026 Diao et al.
Systematic benchmarking of evaluation paradigms, safety boundaries, and clinical reasoning gaps for multimodal large language models in rehabilitation
Abstract Motor rehabilitation and clinical biomechanical assessment rely on expert judgement to evaluate movement quality, pathological compensation, and spatiotemporal motor dynamics. Existing automated approaches mainly depend on conventional computer vision methods, such as skeletal keypoint-based analysis, but they provide limited clinical semantic interpretation and mechanistic reasoning.
Influence of side-hole configuration on recirculation in dual-lumen cannulas for veno-venous extracorporeal membrane oxygenation: a parametric computational fluid dynamics study
Abstract Introduction: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) increasingly utilizes dual-lumen cannulas (DLCs) to facilitate single-site cannulation. However, challenges such as recirculation and elevated wall shear stress (WSS) continue to impede their efficacy. The influence of the geometric configuration of drainage side holes on these hemodynamic parameters remains inadequately characterized.
A personalized simulation framework for optimizing orthokeratology lens parameters based on 3D corneal modeling and biomechanical analysis
Abstract The aim of this study was to develop a patient-specific finite element model (FEM) to elucidate the biomechanical mechanisms governing orthokeratology (OK) lens design in real ocular conditions. Based on clinical corneal topography data, a patient-specific FEM was developed to incorporate asymmetric anatomical features. This model integrated an improved Iterative Closest Point (ICP) algorithm and a non-uniform squeeze-film pressure field.
ZBTB7A-mediated regulation of astrocytic glycolysis in neurodegenerative diseases: insights from literature review and bioinformatics prediction
Abstract The incidence of neurodegenerative diseases, including Alzheimer’s disease (AD), continues to increase with the extension of human lifespan. However, their pathogenesis remains incompletely understood. Altered energy metabolism, particularly glucose metabolism involving glycolysis and oxidative phosphorylation, is widely recognized as an early pathological feature of neurodegenerative diseases.
Divergent Egg-Rejection Strategies Between Laying and Incubation Periods in the Green-Backed Tit ( Parus monticolus )
1 Introduction Avian brood parasitism represents a remarkable evolutionary strategy in which parasitic species such as cuckoos (Cuculus spp.) lay their eggs in host nests to exploit parental care (Davies 2000). This parasitic relationship imposes substantial fitness costs on hosts, driving the evolution of sophisticated anti-parasitic defenses including nest protection, egg recognition, and nestling discrimination (Davies 2011; Soler 2014).
Seasonal Variation in Microhabitat Use of the Silver Pheasant ( Lophura nycthemera ) in Laojunshan National Nature Reserve, China
1 Introduction Habitat use is a crucial aspect of behavioral ecology, revealing how animals interact with their environment to satisfy essential needs at different life stages (Johnson 1980; McGarigal et al. 2016). For ground-dwelling birds with limited dispersal ability, understanding the patterns of microhabitat use is particularly important, as fine-scale environmental factors directly impact foraging success, predator avoidance, and reproductive outcomes (Martin 1998; Specht et al.
ESO based adaptive neural network control for a quadrotor against wind and payload disturbances - Scientific Reports
Abstract This paper investigates the design of a robust controller for the trajectory tracking issue of an underactuated quadrotor unmanned aerial vehicle (UAV) subject to multiple disturbances. An anti-disturbance control framework is proposed by utilizing extended state observer (ESO) and neural network technology. Firstly, the dynamic model of the quadrotor UAV under wind and payload disturbance is established.
Discovery of Zilucoplan: A Complement C5 Inhibitor for Treatment of Anti-Acetylcholine Receptor (AChR) Antibody-Positive Generalized Myasthenia Gravis (gMG)
Special Issue Published as part of Journal of Medicinal Chemistry special issue “Peptide Therapeutics”. Introduction Click to copy section linkSection link copied! The complement system plays a crucial role in the innate immune response, and its dysregulation contributes to various autoimmune diseases, such as paroxysmal nocturnal hemoglobinuria (PNH), atypical hemolytic uremic syndrome (aHUS), and generalized myasthenia gravis (gMG).
Discovery of Zilucoplan: A Complement C5 Inhibitor for Treatment of Anti-Acetylcholine Receptor (AChR) Antibody-Positive Generalized Myasthenia Gravis (gMG)
To enable once-daily dosing and achieve complete and continuous complement control for all patients with anti-AChR antibody-positive gMG, a lipidation strategy was applied to further improve PK through albumin binding. (26) From a previous Ala scan, it was known that C-terminal Nvl was not required for affinity. Therefore, position 15 was chosen as the site for derivatization, and Lys was chosen as the vector at this position (compound 39 , IC50 2.5 nM, Table 4 ).
Realgar‐Induced CNS Toxicity: Exploring OTC‐Mediated Ornithine Regulation of ZBTB7A Inhibits Astrocyte Glycolysis Based on the Liver-Brain Axis
1 Introduction Realgar, a mineral-based traditional Chinese medicine (TCM) containing arsenic, has been used in China for more than 2000 years.[1, 2] Several classic prescriptions, such as Angong Niuhuang pills for stroke treatment, Niuhuang Jiedu tablets for clearing heat and removing toxins, and Paediatric Zhi Baodan, all contain different doses of realgar.[3] However, the persistent traditional belief that “TCM has no toxic side effects” leads some individuals to misuse realgar-containing...
Irreversible Electroporation of AC16 Cardiomyocytes Induced by Nanosecond High Voltage Pulse In Vitro
Background Cardiomyocyte lines are widely used in cardiovascular research. For cardiac ablation, the factors affecting cardiomyocytes by pulsed electrical field (PEF) ablation are being investigated due to the sensitivity of cardiomyocytes to electrical pulses. Previous studies have shown that AC16 death is independent of the number and frequency of PEF.
Pharmacokinetic and Metabolism Study of Ginkgolide C in Rats by UPLC‐Q‐TOF‐MS and UPLC‐MS/MS
Conflicts of Interest The authors declare no conflicts of interest. References , , and . 2007. “Ginkgolide C Inhibits Platelet Aggregation in cAMP- and cGMP-Dependent Manner by Activating MMP-9.” Biological & Pharmaceutical Bulletin 30, no. 12: 2340–2344. Food and Drug Administration, Food and Drug Administration. 2018. “ Bioanalytical Method Validation.” https://www.fda.gov/media/70858/download. , , , et al. 2024.
Knowledge, Attitudes, and Practices of Chinese Breast Cancer Patients Towards Comprehensive Postoperative Self-Management: a Cross-Sectional Study
Abstract Purpose To comprehensively assess the knowledge, attitudes, and practices (KAP) of Chinese breast cancer (BC) patients regarding postoperative self-management (POSM) and identify factors influencing self-management behaviors. Methods Questionnaire surveys were administered to BC patients who underwent surgery. A total of 566 participants (98.94% female), mainly from rural areas (65.55%) and married (97.53%), were included.
Knowledge, Attitudes, and Practices of Breast Cancer Patients towards | JMDH
Introduction Breast cancer (BC), characterized by the uncontrolled proliferation of abnormal cells in breast tissue, presents a significant global health challenge, with 2.3 million cases diagnosed and 670,000 deaths recorded in 2022 alone.1 In China specifically, breast cancer has become the most commonly diagnosed cancer among women, with approximately 416,371 new cases and 117,174 deaths reported in 2020.2 The age-standardized incidence rate has increased from 21.6 per 100,000 women in...
Forests | Free Full-Text | Does the Comprehensive Commercial Logging Ban Policy in All Natural Forests Affect Farmers’ Income?-An Empirical Study Based on County-Level Data in China
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Effects of exercise regulated the Nrf2 / HO-1 pathway on improving HFFC diet-induced oxidative stress in hepatocytes
Abstract: Objective To explore whether voluntary wheel running affects liver oxidative stress by regulating the Nrf2 / HO-1 pathway, thereby alleviating HFFC diet-related lipid deposition in the liver. Methods Eight-week-old C57BL/ 6J mice were randomly divided into a normal diet group ( NC group, n= 10) and high-fat, fructose, and cholesterol diet group (HFFC group, n= 20) after 1 week of adaptive feeding.
Multimodal Features Alignment for Vision-Language Object Tracking
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle Multimodal Features Alignment for Vision–Language Object Tracking 1 School of Aeronautics and Astronautics, Shanghai Jiao Tong University, Shanghai 200240, China 2 Artificial Intelligence Key Laboratory of Sichuan Province, Sichuan University of Science and Engineering, Yibin 644000, China * Author to whom correspondence should be addressed. Remote Sens.
Analysis of the Radiator Loss Safety Boundary of a Space Reactor Gas Turbine Cycle with Multiple PCU Modules
1. Introduction With the continuous improvement of science and technology, humans have gradually seen the mysteries of the universe through planetary and satellite detection devices. The development of space exploration technologies such as planetary bases and orbital propulsion has higher requirements for space power systems. Therefore, studying safe, efficient, and compact space power systems is of great significance [1,2].
Lysosomal-associated protein transmembrane 5 ameliorates non-alcoholic steatohepatitis by promoting the degradation of CDC42 in mice - Nature Communications
Our results demonstrated that LAPTM5 could be ubiquitination degraded by NEDD4L under metabolic stresses. Overexpression of LAPTM5 attenuated liver steatosis, inflammatory response, and fibrosis. Mechanistically, LAPTM5 can directly bind to CDC42, promotes its lysosomal degradation, and then inhibit the activation of c-Jun NH2-terminal kinase signaling pathway, thus serving its function. Hepatocyte LAPTM5 is a promising therapeutic target for NASH.
Anti-Penetration Performance of Composite Structures with Metal-Packaged Ceramic Interlayer and UHMWPE Laminate
4.3.2. The Failure Mechanisms of Studied Structure during the Penetration The most important energy-absorbing component for the test target is the metal-packaged ceramic interlayer and the UHMWPE laminate. Figure 10 presents the energy absorption ratio of each part of the composite structure for the target in the anti-penetration process.
Weight-Control Behaviors and Dietary Intake in Chinese Adults: An Analysis of Three National Surveys (2002–2015)
1. Introduction Overweight and obesity have become a public health concern in recent years, and weight control is an essential component for addressing this issue [1]. Effective weight control relies heavily on dietary management, which can be achieved through various energy-restricted and healthy dietary interventions such as low-fat, low-carbohydrate, and Mediterranean diets [2,3].
"EXPECTATION IN THE STOCK MARKET" by Ping Ye
Article Title EXPECTATION IN THE STOCK MARKET Abstract The stock market is always hard to predict. Knowing some facts about expectations and paradoxes will help people to make decisions. Expectations, allais paradox and prospect theory will be discussed to reveal the mystery of winning or losing money in the stock market. Recommended Citation Ye, Ping (2023) "EXPECTATION IN THE STOCK MARKET," Georgia Journal of Science, Vol. 81, No. 1, Article 115.
"Understanding the Hemingway Measure of Adult Connectedness Survey by U" by Gildardo Maya Bautista and Ping Ye Ph.D.
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Terahertz Absorption Properties of Two Solid Amino Acids and Their Aqueous Solutions
A new type of embedded cyclic olefin copolymer microfluidic chip was designed and combined with terahertz (THz) technology to study the effects of glycine and arginine on the THz wave absorption characteristics. This study aims to understand the interactions between solid amino acid molecules and between amino acid and water molecules and to determine the changes in their microstructure.
Effect on age on clinical and immunologic efficacy of peanut sublingual immunotherapy
The Influence of Early and Continuous Exposure of Infants to Cow's Milk Formula on The Occurance of Milk Allergy
Sparrows use a medicinal herb to defend against parasites and increase offspring condition
Canchao Yang Canchao Yang Affiliations Ministry of Education Key Laboratory for Ecology of Tropical Islands, College of Life Sciences, Hainan Normal University, Haikou 571158, China Search for articles by this author Ping Ye Ping Ye Affiliations Ministry of Education Key Laboratory for Ecology of Tropical Islands, College of Life Sciences, Hainan Normal University, Haikou 571158, China Search for articles by this author Juan Huo Juan Huo Affiliations Ministry of Education Key Laboratory for...
Sublingual immunotherapy effective and safe treatment for peanut allergy
Organisation: Position: Deadline Date: Location: Sublingual immunotherapy, a new treatment for peanut, could offer patients a safe and effective way to protect themselves from severe allergic reactions or even anaphylaxis, found a study partly funded by the National Institutes of Health. People allergic to peanuts may have a new way to protect themselves from severe allergic reactions to accidental peanut exposure.
Long-term sublingual immunotherapy for peanut allergy in children: Clinical and immunologic evidence of desensitization
An estimated 6% to 8% of children are affected by food allergy,1x1Sicherer, S.H. and Sampson, H.A. Food allergy: epidemiology, pathogenesis, diagnosis, and treatment. J Allergy Clin Immunol. 2014; 133: 291–308 Abstract | Full Text | Full Text PDF | PubMed | Scopus (685) | Google ScholarSee all References, 2x2Iweala, O.I., Choudhary, S.K., and Commins, S.P. Food allergy. Curr Gastroenterol Rep.
Genetic diversity between mouse strains allows identification of the CC027/GeniUnc strain as an orally reactive model of peanut allergy
To view the full text, please login as a subscribed user or purchase a subscription. Click here to view the full text on ScienceDirect. Fig 1 CC screening approach. Schematic showing 4 representative strains of the 16 strains screened. Six female mice between the ages of 4 and 6 weeks from each strain were mixed so that each cage contained 3 to 5 mice from different strains.
Baseline type 2 diabetes had a significant association with elevated high sensitivity cardiac troponin T levels in Chinese community-dwelling population: a 5-year prospective analysis | Nutrition & Metabolism | Full Text
In Chinese community-dwelling population, the present analysis observed that there was a significant increment of hs-cTnT levels, and baseline T2D had a significant association with elevated hs-cTnT levels during the 5 years of follow-up. Moreover, the present analysis demonstrated that PBG but not FBG played a crucial role in this association in Chinese community-dwelling population without CAD.
A General and Rapid Route to Crystalline Metal Sulfide Nanoparticles for Photocatalytic H2 Generation
W. Xu, P. Ye, J. Iocozzia, H. Zhang, Y. Yuan and Z. Lin, J. Mater. Chem. A, 2017, Accepted Manuscript , DOI: 10.1039/C7TA07544H If you are not the author of this article and you wish to reproduce material from it in a third party non-RSC publication you must formally request permission using RightsLink. Go to our Instructions for using RightsLink page for details.
Highly stable non-noble metal Ni2P co-catalyst for increased H2 generation by g-C3N4 under visible light irradiation
Nickel phosphide (Ni2P) was grown on a graphitic carbon nitride (g-C3N4) surface by annealing a mixture of g-C3N4, NiCl2, and NaH2PO2 at 400 oC for 2 h in Ar atmosphere. During the annealing, Ni2P particles and intimate interfaces between Ni2P and g-C3N4 formed concurrenty.
Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis
Previous studies mainly focused on the role of the epidermal growth factor receptor (EGFR) in tumor cells, whereas the effects of the EGFR on immune responses has not been determined. Our study shows that the EGFR signaling pathway play a role in the regulation of regulatory T cells (Treg cells) in cancer patients. The EGF-like growth factor Amphiregulin (AREG) protein was frequently up-regulated in a tissue microarray, which was associated with worse overall survival.
Amphiregulin Confers Regulatory T Cell Suppressive Function and Tumor Invasion via the EGFR/GSK-3β/Foxp3 Axis
Previous studies mainly focused on the role of Epidermal growth factor receptor (EGFR) in tumor cells, while the effects of EGFR on immune responses has not been determined. Our study shown that EGFR signaling pathway play a role in regulation of Treg cells in cancer patients.
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