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Pingting Ying on Muck Rack

Pingting Ying

As seen in: Nature, Cancer Epidemiology, Biomarkers & Prevention, European Journal of Cancer
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Articles

Targeting WIP1 reprograms immunosuppressive tumor microenvironment to potentiate immunotherapy response in colorectal cancer

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By Lini Chen, Shijin Yuan, Yanmei Wang, Hanying Wang, Liyuan Zhu, Chandra Wijaya, Jiaying Shen, Dingwei Chen, Pingting Ying, Chaoqun Wang, Chentao Li, Xian Wang, Lifeng Feng, Hongchuan Jin, Miaoqin Chen, Jinye Xu
| Nature Verified
Abstract While immunotherapy based on immune checkpoint inhibitors (ICIs) shows limited efficacy in colorectal cancer (CRC) due to its immunosuppressive tumor microenvironment, strategies to activate innate immunity remain underexplored. Here, we identified wild-type p53-induced phosphatase 1 (WIP1/PPM1D) as a critical immunosuppressive driver in CRC, with its expression significantly upregulated in tumor tissues.
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By Ying Zhu, Jianbo Tian, Xiaoyang Wang, Xiating Peng, Nan Yang, Pingting Ying, YUE LI, Ming Zhang, Yimin Cai, Yao Li, Rong Zhong, Jiang Chang, Xiaoping Miao, Xiating Peng, Haoxue Wang, Zequn Lu, Siyuan Niu
| European Journal of Cancer Verified
Highlights • CAV1-CAV2 locus associates with pancreatic ductal adenocarcinoma (PDAC) prognosis. • rs10249656 enhances CAV2 expression through abolishing miR-548s binding. • CAV2 upregulation is significantly correlated with the poor prognosis of PDAC. • CAV2 promotes PDAC cells migration and metastasis without affecting proliferation. • CAV2 perturbs the focal adhesion and extracellular matrix organisation pathways.
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Genetic Predisposition to Colon and Rectal Adenocarcinoma Is Mediated by a Super-enhancer Polymorphism Coactivating CD9 and PLEKHG6

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By Juntao Ke, Jianbo Tian, Shufang Mei, Pingting Ying
| Cancer Epidemiology, Biomarkers & Prevention
Research Articles Juntao Ke, Jianbo Tian, Shufang Mei, Pingting Ying, Nan Yang, Xiaoyang Wang, Danyi Zou, Xiating Peng, Yang Yang, Ying Zhu, Yajie Gong, Zhihua Wang, Jing Gong, Rong Zhong, Jiang Chang and Xiaoping Miao DOI: 10.1158/1055-9965.EPI-19-1116 Published April 2020 Abstract Background: Genome-wide association studies (GWAS) have identified dozens of loci associated with colon and rectal adenocarcinoma risk.
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