Qiushuo Shen

Highlights • Construction of a high-resolution Hi-C map of macaque fetal brain • Cross-species 3D genome analyses uncover human-specific chromatin structures • The subplate lamina shows human-specific regulatory changes during corticogenesis • The human-specific loop regulating EPHA7 affects neuron dendrite development Summary Elucidating the regulatory mechanisms of human brain evolution is essential to understanding human cognition and mental disorders.

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To identify genes whose expression change may confer risk of SCZ, we systematically integrated genetic association signals from the largest SCZ GWAS so far (PGC2)20 and brain eQTL data24 by using a Bayesian statistical framework (Sherlock)25. We identified 10 promising SCZ susceptibility genes whose expression may contribute to SCZ risk.