Yingping Hou

Keywords 3D genome enhancer network cortical neurogenesis human brain evolution Get full text access Log in, subscribe or purchase for full access. References 1. Geschwind, D.H. ∙ Rakic, P. Cortical Evolution: Judge the Brain by Its Cover Neuron. 2013; 80:633-647 2. Won, H. ∙ Huang, J. ∙ Opland, C.K. ... Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility Nat. Commun. 2019; 10, 2396 3. Rakic, P. ∙ Ayoub, A.E. ∙ Breunig, J.J. ...

Abstract The chromatin in the human brain cortex shows more enhancer-enhancer contacts than in macaques and mice, yet the organization of these contacts across cellular states and their mechanisms remain unclear. Here, we developed SCOPE-C, a cost-effective technique designed for mapping DNase I Hypersensitive Sites and their spatial interactions, with the potential for scalability to single-cell resolution.

Yongzheng Li1,2 na1, Boxin Xue1,3 na1, Mengling Zhang1 na1, Liwei Zhang4, Yingping Hou5, Yizhi Qin1, Haizhen Long4, Qian Peter Su1,6, Yao Wang1, Xiaodong Guan1, Yanyan Jin7, Yuan Cao1, Guohong Li4,8 & Yujie Sun ORCID: orcid.org/0000-0002-9489-48201,9 Genome Biology volume 22, Article number: 206 (2021) Cite this article Abstract Background Metazoan cells only utilize a small subset of the potential DNA replication origins to duplicate the whole genome in each cell cycle.