Kathy McCoy on Muck Rack

Kathy McCoy

California
As seen in: Color Research & Application, Nature, The Conversation, Science Magazine, Medical Xpress, Cell Press, Independent Online, EconoTimes, The Journal of Immunology, Canadian Journal of Dietetic Practice & Research
Content Marketing for Health IT and other technology; Fascinated by #mHealth & IOT; dog lover. 2014, 2013 & 2012 #HIT100 member. Opinions are my own.

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Articles

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF - Nature Immunology

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By Victor Kreiner, Aline Ignácio, David Bejarano, Mitchell Bijnen, Hannah Van Hove, Colin Sparano, Ricardo Fróis-Martins, Alexandre Gallerand, Laura Oberbichler, Rachel Lindemann, Anja Kipar, Kathy McCoy, Calum C. Bain, Christoph Schneider, Stoyan Ivanov, Sonia Tugues, Melanie Greter, Florent Ginhoux, Andreas Schlitzer, Elaine Emmerson, Donatella DeFeo, Salomé Leibund Gut-Landmann
| Nature Verified
Abstract Granulocyte-macrophage colony-stimulating factor (GM-CSF, Csf2) is a potent proinflammatory cytokine1. At steady state, however, GM-CSF has a distinct homeostatic function, being essential for the differentiation and maintenance of alveolar macrophages2,3,4,5. Whether macrophage development in nonpulmonary tissues is similarly dependent on GM-CSF is unclear. Here we examine developing tissues of GM-CSF fate-mapping and reporter mice6.
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Dysbiosis of a microbiota–immune metasystem in critical illness is associated with nosocomial infections - Nature Medicine

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By Jared Schlechte, Christopher J. Doig, Kathy McCoy
| Nature Verified
Abstract Critically ill patients in intensive care units experience profound alterations of their gut microbiota that have been linked to a high risk of hospital-acquired (nosocomial) infections and adverse outcomes through unclear mechanisms. Abundant mouse and limited human data suggest that the gut microbiota can contribute to maintenance of systemic immune homeostasis, and that intestinal dysbiosis may lead to defects in immune defense against infections.
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Microbiota regulates intratumoral monocytes to promote anti-tumor immune responses

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By Kathy McCoy, Markus B. Geuking
| Cell Press Verified
The gut microbiota has been shown to promote the efficacy of cancer therapy through regulating adaptive immune responses. In this issue of Cell, Lam et al. provide new evidence demonstrating that specific gut bacteria also reprogram the innate immune tumor microenvironment to enhance the efficacy of cancer therapies.
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