Rachel Weissman

Rachel Weissman, executive coach and keynote speaker, helps Fortune 500 and startups master strategic communication and leadership presence. The leaders I work with are not struggling because they lack intelligence, preparation or ambition. They are struggling because the rate of change around them has outpaced their internal capacity to meet it. That gap, between what the moment demands and what a leader can actually be with, is the defining challenge of leadership right now.

Abstract TnpB is a diverse family of RNA-guided endonucleases associated with prokaryotic transposons. Because of their small size and putative evolutionary relationship to CRISPR–Cas12, TnpB enzymes hold great potential for genome editing. However, most TnpBs lack robust gene-editing activity. Here, we mapped comprehensive sequence–function landscapes of a TnpB ribonucleoprotein using deep mutational scanning and we discovered activating mutations in both the RNA and the protein.

On a recent Saturday, the people of Manitou Springs and beyond converged for an offbeat local tradition befitting of this quirky snow-globe mountain town. Behold the Great Fruitcake Toss. Now in its 31st year, the annual event gives people a chance to toss some fruitcake and get to know the community.