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Articles by Ren Ren
From DragonCon to the Aisle: A Seasonal Wrap-Up with Makeup by Ren Ren
Hi Bellas! Can you believe fall is already here? While the weather is finally cooling down, things have been non-stop at Makeup by Ren Ren! This summer was a total whirlwind—I’ve been bouncing from crazy SFX transformations at DragonCon to all the gorgeous bridal glam that comes with my favorite (and second busiest!) wedding month. It’s been such a fun, creative ride lately.
Single‐Molecule Protein Profiling Using Nanopores and Dimeric Aptamer‐Modified DNA Carriers
Introduction Early detection of diseases, particularly in cases such as cancer and neurodegenerative disorders, holds significant potential to enhance treatment efficiency, life quality, and survival rates.[1] However, biomarkers in early disease stages often exhibit low abundance and dynamic, transient nature compared to advanced stages, making them elusive for detection.[2] Conventional detection methods, such as lateral flow assays (LFAs) and enzyme-linked immunosorbent assays (ELISAs),...
Back Cover: Quantum Mechanical Tunnelling Probes With Redox Cycling for Ultra‐Sensitive Detection of Biomolecules
Long Yi State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, 310027 China Nanhu Brain-Computer Interface Institute, Second Affiliated Hospital School of Medicine, Hangzhou, Zhejiang, 311100 China Department of Chemistry, Molecular Science Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London, W12 0BZ UK Search for more papers by this author
Recent Advances on DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications
Abstract The modification of DNA bases is a classic hallmark of epigenetics. Four forms of modified cytosine-5-methylcytosine, 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine-have been discovered in eukaryotic DNA. In addition to cytosine carbon-5 modifications, cytosine and adenine methylated in the exocyclic amine-N4-methylcytosine and N6-methyladenine-are other modified DNA bases discovered even earlier.
Quantum Mechanical Tunnelling Probes with Redox Cycling for Ultra‐Sensitive Detection of Biomolecules
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Quinoline-based compounds can inhibit diverse enzymes that act on DNA
Abstract DNA methylation, as exemplified by cytosine-C5 methylation in mammals and adenine-N6 methylation in bacteria, is a crucial epigenetic mechanism driving numerous vital biological processes. Developing non-nucleoside inhibitors to cause DNA hypomethylation is a high priority, in order to treat a variety of significant medical conditions without the toxicities associated with existing cytidine-based hypomethylating agents. In this study, we have characterized fifteen quinoline-based analogs.
Mechanistic dissection of the CHD4 enhancers reveals cooperative functions among the homotypic ZNF410 clustered motifs
Abstract Transcription factors often regulate numerous target genes. However, ZNF410 controls only a single gene, CHD4, in human erythroid cells by its highly restricted chromatin occupancy to the CHD4 locus via two clusters of ZNF410 binding motifs. Here, we uncover that ZNF410 controls chromatin accessibility and activity of the two CHD4 enhancer regions.
The ICF syndrome protein CDCA7 harbors a unique DNA-binding domain that recognizes a CpG dyad in the context of a non-B DNA
Abstract CDCA7, encoding a protein with a C-terminal cysteine-rich domain (CRD), is mutated in immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome, a disease related to hypomethylation of juxtacentromeric satellite DNA. How CDCA7 directs DNA methylation to juxtacentromeric regions is unknown. Here, we show that the CDCA7 CRD adopts a unique zinc-binding structure that recognizes a CpG dyad in a non-B DNA formed by two sequence motifs.
Deep Eutectic Solvents with Different Alkyl Chain Lengths as Inhibitors for Shale in Water-Based Drilling Fluids
Download Hi-Res ImageDownload to MS-PowerPointCite This:Energy Fuels 2024, XXXX, XXX This article has not yet been cited by other publications.
Multiplexed detection of viral antigen and RNA using nanopore sensing and encoded molecular probes - Nature Communications
Abstract We report on single-molecule nanopore sensing combined with position-encoded DNA molecular probes, with chemistry tuned to simultaneously identify various antigen proteins and multiple RNA gene fragments of SARS-CoV-2 with high sensitivity and selectivity. We show that this sensing strategy can directly detect spike (S) and nucleocapsid (N) proteins in unprocessed human saliva.
Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia
Pessler F. Pendergrast P.S. Hernandez N. Purification and characterization of FBI-1, a cellular factor that binds to the human immunodeficiency virus type 1 inducer of short transcripts. Mol Cell Biol. 1997; 17: 3786-3798 Davies J.M. Hawe N. Kabarowski J. Huang Q.H. Zhu J. Brand N.J. Leprince D. Dhordain P. Cook M. Morriss-Kay G. Zelent A. Novel BTB/POZ domain zinc-finger protein, LRF, is a potential target of the LAZ-3/BCL-6 oncogene. Oncogene. 1999; 18: 365-375 Liu C.J. Prazak L. Fajardo M. Yu S. Tyagi N.
Structural basis for human ZBTB7A action at the fetal globin promoter
Highlights • ZBTB7A DNA-binding domain recognizes two stretches of G-rich sequence • HPFH-associated regulatory DNA mutations disrupt ZBTB7A-DNA interactions • ZF1 contains a Pro resulting in a shorter recognition helix • ZF4 has C3H1, instead of C2H2, Zn coordination Summary Elevated levels of fetal globin protect against β-hemoglobinopathies, such as sickle cell disease and β-thalassemia.
ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression
Highlights • A CRISPR screen implicates ZNF410 in fetal globin gene repression • The CHD4 gene is the singular direct ZNF410 target in erythroid cells • Fetal globin genes are exquisitely sensitive to CHD4 levels • Five C2H2 zinc fingers of ZNF410 recognize the major groove of a 14-bp sequence Summary Metazoan transcription factors typically regulate large numbers of genes.
Poplar flower-like nitrogen-doped carbon nanotube @ VS4 composites with excellent sodium storage performance
Poplar flower-like nitrogen-doped carbon nanotube @ VS4 composites with excellent sodium storage performance As a new anode material for sodium-ion batteries (SIBs), VS4 shows impressive energy storage potential due to its unique one-dimensional parallel chain structure, large chain spacing and high sulfur content.
Correction: Single-molecule nanopore sensing of actin dynamics and drug binding
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Single-molecule nanopore sensing of actin dynamics and drug binding
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The Chd1 chromatin remodeler forms long-lived complexes with nucleosomes in the presence of ADP·BeF3− and transition state analogs
Ren Ren1, Samaneh Ghassabi Kondalaji and Gregory D. Bowman2 T. C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218 ↵2 To whom correspondence should be addressed: T. C. Jenkins Dept. of Biophysics, Johns Hopkins University, Baltimore, MD 21218. Tel.: 410-516-7850; E-mail: gdbowman{at}jhu.edu. Edited by Karin Musier-Forsyth ↵1 Present address: Dept. of Epigenetics & Molecular Carcinogenesis, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030.
The Chd1 chromatin remodeler forms long-lived complexes with nucleosomes in the presence of ADP·BeF3- and transition state analogs
Ren Ren1, Samaneh Ghassabi Kondalaji1 and Gregory D.
Widespread Whole Genome Duplications Contribute to Genome Complexity and Species Diversity in Angiosperms
Ks Distributions of Duplicated Genes as Further Evidence for Large-Scale Duplications Estimation of Loss Rate of Gene Duplicates from Known WGDs to Recognize Novel Ones Comprehensive Evaluation of Known and Novel WGDs Based on Loss Rate of Duplicates Retention of Duplicated Genes in Species with Both Ancestral and Recent WGDs Occurrence of WGDs Is Correlated with Global Climate Changes Scale of Reciprocal Loss of Gene Duplicates for Increasing Genomic Diversity of Plants Estimation of Gain...
HF-free synthesis of Si/C yolk/shell anodes for lithium-ion batteries
Silicon anodes for lithium-ion batteries have attracted extensive investigation due to their very high theoretical capacity; however, with huge volume change upon lithiation, their cyclic performance has yet to be improved for commercial applications. While yolk/shell Si/C has been proven to possess enhanced cyclic performance due to rich voids, its preparation requires HF to remove templates, which is not environmentally friendly and needs precaution.
Nanopore extended field-effect transistor for selective single-molecule biosensing
The nexFET is fabricated using a double-barrel quartz nanopipette (Supplementary Figs. 1–3) by feedback controlled pyrrole electropolymerization (Fig. 2a–d). Nanopipettes are sub-class of nanopore sensors that have been shown to be easy and rapid to fabricate at low cost10, 11, 23,24,25,26. Unlike previous reports, we show that a dual-barrel nanopipette can be functionalized and operated as a nanopore and ionic FET in a single platform.
Makeup By Ren Ren - August Beauty Favorites
I'm back with another monthly favorites! There are some really awesome new products and some oldies too that made a comeback. Enjoy! Check out the video! Hi Bellas, I've seen these adorable cases for a while now and I'm glad my girl convinced me to get one at PhamExpo. They're really nice to store lashes and won't get them all banged up. Plus they look super cute on your vanity.
You're Invited: Epic Atlanta Beauty Event with AJ Crimson & Makeup By Ren Ren
Hi Bellas, Happy Friday! Today I'm super excited to share with you details for a huge event next Saturday here in Atlanta. I'm pairing up with AJ Crimson, Celebrity Makeup Artist to launch an epic beauty event. Check it out for more! Check out the video for all the details! For those in Atlanta, here are the details: Date Saturday, June 15th, 12pm-7pm and 8pm-10pm Venue The event will take place at BlushBaby Makeup Studio 2295 Peachtree Road NE Atlanta, GA 30309 Free parking in the back.
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