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René Pool

As seen in: Nature, Frontiers, MDPI, BioRxiv, medRxiv, Biological Psychiatry, Alzheimer's & Dementia
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Articles by René Pool

APOE ε4 carriership status enhances age-related changes in Alzheimer’s disease plasma biomarkers concentrations

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By Rebecca Z Rousset, Anouk den Braber, Lynn Boonkamp, David Wilson, Lannie Ligthart, René Pool, Pieter Jelle Visser, Eco de Geus, Charlotte Teunissen, Bram Bongers, Sophie M. van der Landen
| Nature Verified
Abstract Alzheimer’s disease (AD) plasma biomarkers are cost-effective tools to detect early stage amyloid pathology. We investigated how interactions between AD genetic risk (apolipoprotein E (APOE) ε4, AD polygenic risk score (excluding APOE; PRSAD)), age, and sex affected AD plasma biomarkers concentrations in a population-based cohort.
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Genome-wide association studies of infant and toddler temperament in European and multi-ancestry populations

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By Anja Hollowell, Anna Gui, Emilie M. Wigdor, Morgan J. Morgan, Laurie J. Hannigan, Elizabeth C Corfield, René Pool, Susanne Bruins, Helga Ask, Christel M. Middeldorp, Meike Bartels, Dorret I. Boomsma, Catharina A Hartman, Aoi Noda, Ippei Takahashi, Mami Ishikuro, Taku Obara, Shinichi Kuriyama, Mary S. Mufford, Marilyn Lake, Dan Stein, Heather J Zar, Nadia Hoffman, Elise B. Robinson, Anders D. Børglum, Xinhe Zhang, Varun Warrier, Tomoki Arichi, Mark Johnson, Frank Dudbridge, Stephan Sanders, Alexandra Havdahl, Angelica Ronald
| Nature Verified
Abstract Early temperament, such as socio-emotional development and activity level, varies widely, yet its underlying biological associations are not understood. We identified genetic variation associated with infant and toddler temperament using genome-wide association meta-analyses. We studied parent-rated emotionality, activity, shyness and sociability (n = 43,963–72,663) in the second and third postnatal years and a cross-age average.
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Genetic and environmental influences on educational disparities in adult weight change: an individual-based pooled analysis of 11 twin cohorts

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By Alvaro Obeso, Gabin Drouard, Aline Jelenkovic, Emanuela Medda, Corrado Fagnani, Virgilia Toccaceli, Antti Latvala, Sari Aaltonen, Sarah E. Medland, Scott Gordon, Jooyeon Lee, soo lee, Joohon Sung, Glen Duncan, Dedra Buchwald, Juan R. Ordoñana, Juan F. Sánchez-Romera, Carol E. Franz, William S. Kremen, Robin P. Corley, Brooke M. Huibregtse, Patrik Magnusson, Ida Karlsson Verified, Michael Lyons, Meike Bartels, Lannie Ligthart, Eco de Geus, Margaret Gatz, David Butler, René Pool, Anders Eriksson, Susanne Bruins, Nicholas Martin, Dorret I. Boomsma, Jaakko Kaprio, Karri Silventoinen, Hyojin Pyun, Eduvigis Carrillo, Anna K. Dahl Aslan
| Nature Verified
Abstract Educational attainment (EA) is negatively associated with body mass index (BMI), but less is known about the association between EA and adult BMI change. We analysed the role of genetic and environmental factors in the associations between EA and BMI trajectory components over adulthood. Pooled data from 59,490 twins aged 31–99 years (49% women) across 11 cohorts with EA and repeated measures of BMI were used.
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Genetics of Major Depressive Disorder in a Homogeneous Population with Uniform Phenotyping

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By Floris Huider, Yuri Milaneschi, René Pool, Scott Gordon
| medRxiv
The authors have declared no competing interest. We are very grateful to everyone who participated in this research or worked on this project and its contributing studies. Funding for the BIONIC project was awarded to Dorret Boomsma and Brenda Penninx by the Biobanking and Biomolecular Resources Research Infrastructure (BBMRI-NL: 184.021.007; 184.033.111). Below are cohort-specific funding declarations and acknowledgements.
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Genome-wide association meta-analysis of age at onset of walking in over 70,000 infants of European ancestry - Nature Human Behaviour

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By Anna Gui, Anja Hollowell, Emilie M. Wigdor, Morgan J. Morgan, Laurie J. Hannigan, Elizabeth C Corfield, Veronika V. Odintsova, Jouke-Jan Hottenga, Andrew Wong, René Pool, Harriet Cullen, Sian Wilson, Varun Warrier, Espen M. Eilertsen, Ole A. Andreassen, Christel M. Middeldorp, Meike Bartels, Dorret I. Boomsma, Catharina A Hartman, Elise B. Robinson, Tomoki Arichi, Anthony Edwards, Mark Johnson, Frank Dudbridge, Stephan Sanders, Alexandra Havdahl
| Nature Verified
Abstract Age at onset of walking is an important early childhood milestone which is used clinically and in public health screening. In this genome-wide association study meta-analysis of age at onset of walking (N = 70,560 European-ancestry infants), we identified 11 independent genome-wide significant loci. SNP-based heritability was 24.13% (95% confidence intervals = 21.86–26.40) with ~11,900 variants accounting for about 90% of it, suggesting high polygenicity.
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Intergenerational transmission of complex traits and the offspring methylome - Molecular Psychiatry

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By Fiona A. Hagenbeek, René Pool, Erik A. Ehli, August B. Smit, Meike Bartels
| Nature Verified
Abstract The genetic makeup of parents can directly or indirectly affect their offspring phenome through genetic transmission or via the environment that is influenced by parental heritable traits. Our understanding of the mechanisms by which indirect genetic effects operate is limited. Here, we hypothesize that one mechanism is via the offspring methylome.
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Blood-Based EWAS of Asthma Polygenic Burden in The Netherlands Twin Register

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By René Pool, Jouke-Jan Hottenga, Jeffrey J. Beck, Casey T. Finnicum
| MDPI
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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The association between metabolite concentrations and wellbeing in adults

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By René Pool, Dirk H.M. Pelt, Natalia Azcona Granada, Anne J.M.R. Geijsen
| BioRxiv
Abstract The biological complexity of wellbeing is studied from various perspectives, including genetics and epigenetics. However, there is a knowledge gap concerning other layers, such as metabolomics, which is dynamic and changes throughout life. This study explores the association between metabolites and wellbeing in a sample (N = 4748) drawn from the Netherlands Twin Register.
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Intergenerational transmission of complex traits and the offspring methylome

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By Fiona A. Hagenbeek, René Pool, Erik A. Ehli, Meike Bartels
| medRxiv
The authors have declared no competing interest. The current work is supported by the Consortium on Individual Development (CID) and the "Aggression in Children: Unraveling gene-environment interplay to inform Treatment and InterventiON strategies" project (ACTION). CID is funded through the Gravitation Program of the Dutch Ministry of Education, Culture, and Science and the Netherlands Organization for Scientific Research (NWO grant number 024-001-003).
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Genome-Wide Association Study of Obsessive-Compulsive Symptoms including 33,943 individuals from the general population - Molecular Psychiatry

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By Nora I. Strom, Christie L. Burton, René Pool, James J. Crowley, Jouke-Jan Hottenga, Henrik R. Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, David Mataix-Cols, Dorret I. Boomsma, Manuel Mattheisen
| Nature Verified
Abstract While 1–2% of individuals meet the criteria for a clinical diagnosis of obsessive-compulsive disorder (OCD), many more (~13–38%) experience subclinical obsessive-compulsive symptoms (OCS) during their life.
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Genome-wide characterization of circulating metabolic biomarkers - Nature

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By Minna K. Karjalainen, Eeva Sliz, Elias Allara, Weihua Zhang, Pekka Jousilahti, Kati Kristiansson, Veikko Salomaa, David Hughes, Michael Boehnke, Lilian Fernandes Silva, Xianyong Yin, Matt Neville, Ayşe Demirkan, Jun Liu, Raymond Noordam, Stella Trompet, Zhengming Chen, Fiona A. Hagenbeek, Jouke Jan Hottenga, René Pool, M. Arfan Ikram, Yuri Milaneschi, Peter K. Joshi, Massimo Mangino, Ilhan E. Acar, Alexander Kurilshikov, Marian Beekman, Ozren Polašek, Christian Gieger, Melanie Waldenberger, Caroline Hayward, Jingyuan Fu, Cristina Menni, Tim Spector, James WIlson, James Wilson, Terho Lehtimäki, Robin G Walters, J. Wouter Jukema, Naveed Sattar, Mohsen Ghanbari, Fredrik Karpe, Mark McCarthy, Markku Laakso, Marjo-Riitta Järvelin, Nicholas J Timpson, Jaspal S Kooner, Cornelia van Duijn, P. Eline Slagboom, Dorret I. Boomsma, Mika Ala-Korpela, Adam S. Butterworth
| Nature Verified
Abstract Genome-wide association analyses using high-throughput metabolomics platforms have led to novel insights into the biology of human metabolism1,2,3,4,5,6,7. This detailed knowledge of the genetic determinants of systemic metabolism has been pivotal for uncovering how genetic pathways influence biological mechanisms and complex diseases8,9,10,11.
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Branched-chain amino acids linked to depression in young adults

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By René Pool, van Kamp, Aurora E. Kerscher, Jean-Michel Le Melledo
| Frontiers
Introduction Depression is a broad and heterogenous mental health problem, which affects 256 million adults and 21 million adolescents worldwide (GHDx Institute of Health Metrics and Evaluation, 2019; last accessed 9Feb2022). In 2019, for the global population of 10–24 and 25–49 year-olds, depression was the fourth and sixth leading causes of disability-adjusted life years (DALY), respectively (Diseases and Injuries, 2020).
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Circulating metabolites and general cognitive ability and dementia: Evidence from 11 cohort studies

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By Charlotte Teunissen, René Pool, Vrije Universiteit Amsterdam, Neuroscience Campus Amsterdam
| Alzheimer's & Dementia Verified
None of the funders had any role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.This work was performed within the framework of the BBMRI Metabolomics Consortium funded by BBMRI-NL, a research infrastructure financed by the Dutch government (NWO, grant nr 184.021.007 and 184033111).
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