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Articles by Robert A. Anders
Prediction of site-specific recurrence and overall survival for colorectal cancer with liver metastases
Abstract Up to 70% of patients with colorectal cancer liver metastases (CRLM) experience recurrence after curative-intent hepatectomy, yet recurrence patterns are heterogeneous across anatomic sites, and no tools currently exist to predict site-specific recurrence dynamically over time.
Mutant KRAS peptide vaccine with dual checkpoint blockade in metastatic colorectal cancer: a phase I trial
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Abstract Immune checkpoint inhibitors (ICIs) have limited activity in mismatch repair proficient or microsatellite stable (MMRp/MSS) colorectal cancer (CRC). KRAS mutations, present in approximately 40% of these cancers, can generate neoantigens that are targets for therapeutic vaccines.
By Hejia Wang, Amanda L Huff, S. Haldar, Maureen Berg, Christopher Thoburn, Thatcher Heumann, Robert A. Anders, Benjamin Barrett, Katherine M. Bever, Michael Pishvaian, Valerie Lee, Dung T Le, Eric Christenson Verified, Marina Baretti, Mark Yarchoan, Daniel A. Laheru, Amy Thomas, Jennifer N. Durham, Jiayun Lu, Hao Wang, Elizabeth Jaffee, Nilofer S. Azad, Neeha Zaidi, Julie M. Nauroth
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Nature
Verified
The combination of a cancer vaccine, pembrolizumab, and stereotactic body radiation in patients with locally advanced pancreatic cancer: a single-arm, phase II study
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Abstract In this Phase II study (NCT02648282) of locally advanced pancreatic cancer (LAPC), 58 patients were enrolled and intended for an immunotherapy including GM-CSF-secreting allogeneic pancreatic cancer vaccine (GVAX) and pembrolizumab and stereotactic body radiation therapy (SBRT) following standard chemotherapy. Fifty-four evaluable patients received two cycles of immunotherapy and SBRT and reassessed for resectability.
By Valerie Lee, Christina Rodriguez, Junke Wang, Hanfei Qi, Rose Parkinson, Thomas McPhaul, Jennifer N. Durham, Amy Hacker-Prietz, Amol K. Narang, Dung T Le, Ana De Jesus, Michael Pishvaian, Eric Christenson Verified, Elizabeth Thompson, Robert A. Anders, Arsen Osipov, Matthew B. Weiss, William Burns, Richard Burkhart Verified, Kelly J Lafaro, Jin He, Christopher L Wolfgang, Elizabeth A. Sugar, Joseph M. Herman, Elizabeth Jaffee, Hao Wang, Daniel A. Laheru, Lei Zheng, Apoorvaa S. Sachidanand, Beth Onners
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Nature
Verified
iCLAP: an innovative method for integrable co-detection of low-abundance antigens with high-plex immunostaining - Nature Communications
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Abstract Multiplexed protein imaging enables spatial analysis of complex tissues, but detecting proteins expressed at low levels remains challenging, particularly in widely available formalin-fixed, paraffin-embedded (FFPE) specimens. Many biologically important regulators—including senescence markers, transcription factors, and secreted proteins—are therefore difficult to study in situ using existing high-plex methods.
By Fan Wu, Shuyuan Zheng, Yani Chen, Peijia Ye, Moo Joong Kim, Seojin Lee, Geroge Kuo, Shriya Pillan, Ruihan Yuan, Bofei Yu, Qingfeng Zhu, Sarah Shin, Courtney Cannon, Gabriele Pierre, Kanako Iwasaki, Cristina Aguayo-Mazzucato, Nicolas Musi, George A. Kuchel, Birgit Schilling, Laura Wood, Won Jin Ho, Robert A. Anders, Denis Wirtz, Pei-Hsun Wu
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Nature
Verified
Immunotherapy response induces divergent tertiary lymphoid structure morphologies in hepatocellular carcinoma - Nature Immunology
Abstract Tertiary lymphoid structures (TLS) are associated with improved response in solid tumors treated with immune checkpoint blockade, but understanding of the prognostic and predictive value of TLS and the circumstances of their resolution is incomplete. Here we show that in hepatocellular carcinoma treated with neoadjuvant immunotherapy, high intratumoral TLS density at the time of surgery is associated with pathologic response and improved relapse-free survival.
Entinostat, nivolumab and ipilimumab for women with advanced HER2-negative breast cancer: a phase Ib trial - Nature Cancer
Abstract We report the results of 24 women, 50% (N = 12) with hormone receptor-positive breast cancer and 50% (N = 12) with advanced triple-negative breast cancer, treated with entinostat + nivolumab + ipilimumab from the dose escalation (N = 6) and expansion cohort (N = 18) of ETCTN-9844 (NCT02453620). The primary endpoint was safety. Secondary endpoints were overall response rate, clinical benefit rate, progression-free survival and change in tumor CD8:FoxP3 ratio.
Association between pathologic response and survival after neoadjuvant therapy in lung cancer - Nature Medicine
Abstract Neoadjuvant immunotherapy plus chemotherapy improves event-free survival (EFS) and pathologic complete response (pCR, 0% residual viable tumor [RVT] in primary tumor [PT]+lymph nodes [LNs]), and is approved for treatment of resectable lung cancer. Pathologic response assessment after neoadjuvant therapy is the potential analog to radiographic response for advanced disease. However, %RVT thresholds beyond pCR and major pathologic response (≤10% RVT) have not been explored.
Coastal groundwater‐dependent ecosystems are falling through policy gaps
Coastal groundwater-dependent ecosystems (GDEs) are biodiversity hotspots that provide valuable ecosystem services to society. However, they face significant threat from groundwater exploitation and depletion, and climate change impacts from sea-level rise and extreme flood and drought events. Despite many well-intentioned policies focused on sustainable groundwater use, coastal GDEs are falling through policy gaps and as a result, are declining in their extent and ecological function.
Multi-Institutional Evaluation of Pathologists’ Assessment Compared to Immunoscore
Open AccessArticle by Joseph Willis 1, Robert A.
A platform trial of neoadjuvant and adjuvant antitumor vaccination alone or in combination with PD-1 antagonist and CD137 agonist antibodies in patients with resectable pancreatic adenocarcinoma | Nature Communications
Ethics and compliance The study was approved by the Johns Hopkins Institutional Review Board (IRB) and Institutional Biosafety Committee (IBC), as well as the FDA Center for Biologics Evaluation and Research and the National Institutes of Health Recombinant DNA Advisory Committee (J1568, NCT02451982). The trial was conducted according to the Declaration of Helsinki and the Good Clinical Practice guidelines of the International Conference on Harmonization.
Impacts of Subsurface Dam Construction on Downstream Groundwater Levels and Salinity in Coastal Aquifers
Research Paper This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/gwat.13304. Abstract Subsurface dam is a promising engineering technology for groundwater resources development.
Mining Exploration Insights – September 2020
Street Talk | Episode 105: Banks could see opportunity in fintech's cleansing fire
Mining Exploration Insights July 2020
S&P Global Market Intelligence's Pipeline Activity Index rose for a third consecutive month in June as increases in significant financings and drill results were partially offset by a drop in initial resources and positive project milestones.
Mining Exploration Insights: Financing Falls To 8-Month Low In October
Mining Exploration Insights: Financing Falls To 8-Month Low In October Drilling activity, initial resources and positive project milestones all improved in October — the number of significant financings was unchanged — as S&P Global Market Intelligence's Pipeline Activity Index, or PAI, jumped to 96 from 84 in September.
Erratum to “How Groundwater Moves Around Structures”
In Spinti and Panthi (2022; 2023a; 2023b), the affiliation for Rachel A. Spinti is corrected as follows: Montgomery & Associates, 1550 E. Prince Rd., Tucson, AZ 85719 References , and . 2022. How groundwater moves around structures. Groundwater 60, no. 6: 713– 713. , and . 2023a. The Waiwhetu aquifer: A layered cake tin. Groundwater 61, no. 1: 19– 20. , and . 2023b. Space heating and cooling with the energy below our feet. Groundwater 61, no. 2: 171– 172.
IM June 2022 - Exploration index falls for 2nd month
Research IM June 2022 — Exploration index falls for 2nd month S&P Global Market Intelligence's Pipeline Activity Index, or PAI, retreated for a second consecutive month in May, falling to 139 from 142 in April, as decreases in significant financings and initial resources were partially offset by increases in significant drill results and positive project milestones. The gold PAI fell to 169 from 181, while the base/other metals PAI rose to 113 from 108.
IM March 2022 - Exploration index holds steady
S&P Global Market Intelligence's Pipeline Activity Index held steady at 137 in February as increases in significant drill results, significant financings and positive project milestones were offset by a sharp decline in initial resources. Base/other metals rose to 92 from 89, while gold fell to 188 from 194.
Expanding the immunotherapy roadmap for hepatocellular carcinoma
Summary In a recent Lancet Oncology article, Yau et al. report the CheckMate 459 trial results. This is the first phase III trial comparing the single-agent anti-programmed death protein 1 (PD-1) therapy nivolumab to the tyrosine kinase inhibitor sorafenib for treatment-naive patients with advanced hepatocellular carcinoma.
Identifying the Ideal Target Vessel Size for Bariatric Embolization: Histologic Analysis of Swine and Human Gastric Fundi
Abstract This study aimed to identify the ideal arteriole size to target in bariatric embolization, with the goal of maximizing weight loss efficacy while maintaining patient safety. Although all published clinical trials of bariatric embolization have used embolic microspheres that were at least 300 μm in diameter, optimal weight loss outcomes have been achieved safely in swine using 50-μm embolics.
Gold RRS 2020 - Top Gold Producers' Reserves In Decline
Hampered by a lack of new discoveries and a shift away from growth-focused strategies toward margin preservation, the world's major gold miners have seen their economically minable gold reserves decline over the past 10 years. With top producers facing declining production profiles, shrinking reserves and rising production costs, we expect many to supplement their depleted pipelines by expanding organic exploration in the near term while leveraging targeted acquisitions.
Mining Exploration Insights - May 2020
With disruptions to mining operations now appearing to be less severe than some had initially feared, mining equities recovered somewhat in April, as S&P Global Market Intelligence's aggregate market value of the industry's listed companies, based on 2,331 firms, rose 18% month over month to US$1.24 trillion. The aggregate market cap of the industry's top 100 companies was up 17% in April at US$1.05 trillion.
Vulnerability of nurse and physicians with COVID‐19: Monitoring and surveillance needed
1 INTRODUCTION SARS‐CoV‐2, the virus that causes COVID‐19, is wreaking havoc around the world. This unprecedented pandemic has led to illness, death and economic destruction. The pandemic has challenged healthcare systems globally for a range of reasons. In developed economies, the focus on noncommunicable diseases rather than infectious diseases has caught us short.
Who speaks for nursing? COVID‐19 highlighting gaps in leadership
EDITORIAL John Daly Corresponding Author E-mail address: profjpd@gmail.com Emeritus Professor Western Sydney University and University of Technology Sydney Corresponding author: John Daly RN PhD FACN FAAN FFN MRCSI Email: profjpd@gmail.com Search for more papers by this author This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this...
The Institute of Australian Geographers Conference Inc. 2020
The Institute of Australian Geographers Conference Inc.
Mining Exploration Insights - December
Mirroring the decrease in the PAI, metals prices declined for the first time in six months in November as S&P Global Market Intelligence's Exploration Price Index, or EPI, dropped to 130 from 132. The indexed price fell for five — gold, silver, nickel, zinc and molybdenum — of the eight constituents of the index and rose slightly for copper, cobalt and platinum.
Mining Exploration Insights Improved Drilling Activity Offset By Drop In Financings
Increases in drilling activity and positive project milestones were no match for decreases in significant financings and initial resources, as S&P Global Market Intelligence's Pipeline Activity Index, or PAI, dropped to 82 from 84 in August.
PD-L1 on host cells is essential for PD-L1 blockade-mediated tumor regression
PD-L1 on tumor cells is dispensable for checkpoint blockade therapy. To test this hypothesis, tissues were collected from MC38 tumor–bearing mice and the PD-L1 expression profiles were evaluated by flow cytometry (Figure 1A). Surprisingly, myeloid cells, including macrophages (CD11b+F4/80+), MDSCs (CD11b+Gr-1+), and DCs (CD11c+), expressed much higher levels of PD-L1 than tumor and stromal (CD45–) cells (Figure 1, B–D).
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