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Publisher Correction: Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
Correction to: Nature https://doi.org/10.1038/s41586-025-09965-1 Published online 14 January 2026 In the version of the article initially published, in Fig. 1g, the three right-hand labels reading “24 h” should have read “SAT1”, “SMARCA1” and “ACTB”. This correction has been made to the HTML and PDF versions of the article, as seen in Fig. 1, below. Fig. 1: Original and corrected Fig.
Polyamine-dependent metabolic shielding regulates alternative splicing - Nature
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Abstract Metabolites are central to cellular homeostasis. Although much emphasis has been placed on their relevance to meet energetic and biosynthetic demands, metabolic intermediates also function as signalling molecules. Here we show that polyamines, small polycations that are critical to cellular homeostasis1,2,3, regulate the process of alternative pre-mRNA splicing.
By Amaia Zabala-Letona, Saioa Garcia-Longarte, Isabel Mendizabal, Malgorzata Ewa Rogalska, Joycelyn Tan, Pilar Ximenez-Embun, Maciej Zakrzewski, Ianire Astobiza, Sarah Cherkaoui, Maria Sendino, Amaia Ercilla, Laura Bozal-Basterra, Juan A. Ferrer-Bonsoms, Joan Seoane, Rosa Barrio, James Sutherland Verified, Ana M. Aransay, Juan Manuel Falcon-Pérez, Barbara Martinez-Pastor, Francisco Blanco, Michael D. Hogarty, Raphael J. Morscher, Remigiusz A. Serwa, Jesús Jiménez-Barbero, Gonzalo Jiménez-Osés, Alejo Efeyan, Lydia W. S. Finley, Javier Muñoz, Juan Valcárcel, Maria Ponce-Rodriguez, Encarnación Pérez-Andrés, Maciej Cieśla
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Antonio García-Barrio, el científico que descifró los planos de la vida adentrándose, como Fritz, en la oscuridad
Una de sus contribuciones clave fue la idea de que los organismos se construyen durante la embriogénesis a partir de módulos de genes selectores que confieren identidad a las distintas partes del cuerpo. Estos genes definen territorios en los tejidos donde se expresan, y las fronteras de dichos territorios son infranqueables para las células, salvo en caso de mutaciones en los genes que los determinan.
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