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Ryan Barnes

As seen in: Wiley Online Library, MDPI, BioRxiv, Cell Press, Cell Reports, The Journal of Biological Chemistry, Lift & Access
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Articles

Oxidative-stress-induced telomere instability drives T cell dysfunction in cancer

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By Dayana B. Rivadeneira, Sanjana A. Thosar, Kevin Quann, William Gunn, Victoria Dean, Bingxian Xie, Andrew McGovern, Kellie Spahr, Konstantinos Lontos, Ryan Barnes, Marcel Bruchez, Patricia L. Opresko, Greg M. Delgoffe, Angelina Parise
| Cell Press Verified
Keywords telomere DNA damage mitochondria ROS T cell dysfunction adoptive cell therapy tumor microenvironment Introduction The functional state of tumor-infiltrating lymphocytes is a critical determinant of antitumor immunity and response to immunotherapy.1 In an environment of antigen persistence and metabolic barriers such as low oxygen tension, T cells progressively lose polyfunctionality and their ability to control tumor cell spread.2 T cells that reach a terminally exhausted state...
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How Type II Helmets Are Changing the Face of Safety Measures at the Job Site

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By Ryan Barnes
| Lift & Access Verified
By Ryan Barnes, CEO and founder, Studson, Inc. From construction sites to oil and gas fields, utilities, mining and any industrial trade, keeping a worker’s head safe remains a top priority for organizations and individuals. However, the technology found in the traditional hard hat contradicts this priority. The basic design of the hard hat has remained virtually unchanged for more than 100 years. The truth is – it is no longer the safest way to protect the brain and head on the job.
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Oxidative guanine base damage plays a dual role in regulating productive ALT-associated homology-directed repair

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By Sanjana A. Thosar, Ryan Barnes, Ariana C. Detwiler, Ragini Bhargava
| Cell Reports Verified
Highlights • The oxidative DNA lesion 8-oxoguanine impairs DNA replication at ALT telomeres • 8-Oxoguanine-induced replication stress stimulates ALT homology-directed repair activity • ALT cancer cells are hypersensitive to chronic telomeric 8-oxoguanine damage • 8-Oxoguanine formation in G2 cell phase impairs ALT-replisome telomere elongation Summary Cancer cells maintain telomeres by upregulating telomerase or alternative lengthening of telomeres (ALT) via homology-directed repair at...
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