Ryan Flynn
- Technician, Agissar Corporation
Los Angeles, Torrington
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Articles by Ryan Flynn
Detection and characterization of in cellulo protein–RNA complexity by irCLIP-RNP, irCLIPv2 and Re-CLIP
Abstract Transcriptome-wide methods to map RNA–protein interactions in living cells provide powerful tools to unravel the complexity of ribonucleoprotein (RNP) assemblies and their roles in post-transcriptional regulation.
A nanoscale map of the human cell surface proteome reveals spatial and functional organization
Abstract The cell surface proteome governs processes essential for development, immunity and disease, yet its large-scale spatial organization remains uncharted. Here, we systematically map the surface proteome of human T lymphocytes and B lymphoblasts using proximity labeling of 85 antigens.
The cellular landscape of druggable RNA-binding proteins
Abstract RNA-binding proteins (RBPs) are involved in every step of RNA metabolism, from RNA processing and modification to translation and decay, and are also important for the function of non-coding RNAs. As such, RBPs are crucial in shaping cell identity and are central to the development of numerous diseases.
East West Manufacturing™ Acquires Vexos, Expanding Engineering Expertise and Global Manufacturing Capabilities
East West Manufacturing, a leading Integrated Manufacturing Solutions (IMS) company that designs and manufactures complex electronic and electro-mechanical products, has announced the acquisition of Vexos, an award-winning electronics manufacturing services (EMS) company.
Defining cell surface and glycosylated RNAs
Keywords glycoRNA cell surface glycobiology sequencing technologies noncoding RNA Get full text access Log in, subscribe or purchase for full access. References 1. Krasnova, L. ∙ Wong, C.-H. Understanding the chemistry and biology of glycosylation with glycan synthesis Annu. Rev. Biochem. 2016; 85:599-630 2. Flynn, R.A. ... Mammalian Y RNAs are modified at discrete guanosine residues with N-glycans bioRxiv. 2019; 3. Flynn, R.A. ...
Paradise Unable to Overcome Deficit in Loss to One Knoxville
Published on April 4, 2026 under United Soccer League One (USL1) Sarasota Paradise News Release Two second half goals were too much for Sarasota to overcome, as the Paradise dropped Saturday's match 2-1 to One Knoxville SC The first half mirrored Sarasota's matchup with AC Boise, as each team was unable to break through the defense of the other. An early scoring chance in the 22nd minute saw Sarasota's Sean Karani float an arcing ball to Jonathan Bolanos, who couldn't find the net.
Paradise Grab Historic First Goal in Draw with Fort Wayne
Published on March 14, 2026 under United Soccer League One (USL1) Sarasota Paradise News Release Sarasota's Sander Røed scored the club's historic first goal off a free kick in the dying seconds of the first half and assisted on another in the second as the Paradise played to a well-earned 2-2 draw against Fort Wayne FC Saturday night in Sarasota.
RNA N-glycosylation enables immune evasion and homeostatic efferocytosis - Nature
Abstract Glycosylation is central to the localization and function of biomolecules1. We recently discovered that small RNAs undergo N-glycosylation2 at the modified RNA base 3-(3-amino-3-carboxypropyl) uridine (acp3U)3. However, the functional significance of N-glycosylation of RNAs is unknown.
Development and application of GlycanDIA workflow for glycomic analysis - Nature Communications
Abstract Glycans modify protein, lipid, and even RNA molecules to form the regulatory outer coat on cells called the glycocalyx. The changes in glycosylation have been linked to the initiation and progression of many diseases. Herein, we report a DIA-based glycomic workflow, termed GlycanDIA, to identify and quantify glycans with high sensitivity and precision.
Publisher Correction: irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA - Nature
Correction to: Nature https://doi.org/10.1038/s41586-025-08787-5 Published online 26 March 2025 In the version of the article initially published, in Fig. 4g, the boxes showing the EGF stimulation time points for 0, 15, 30, 60 min were inadvertently removed during the production process and have now been added to the HTML and PDF versions of the article. About this article Ducoli, L., Zarnegar, B.J., Porter, D.F. et al.
Treatment of acute myeloid leukemia models by targeting a cell surface RNA-binding protein - Nature Biotechnology
Abstract Immunotherapies for acute myeloid leukemia (AML) and other cancers are limited by a lack of tumor-specific targets. Here we discover that RNA-binding proteins and glycosylated RNAs (glycoRNAs) form precisely organized nanodomains on cancer cell surfaces. We characterize nucleophosmin (NPM1) as an abundant cell surface protein (csNPM1) on a variety of tumor types. With a focus on AML, we observe csNPM1 on blasts and leukemic stem cells but not on normal hematopoietic stem cells.
Preparing For The Potential Sale Of Your Business
Deciding that it might be time to explore a sale of a family or founder owned business can be an intimidating task, but what can make it even more daunting is being unprepared for what comes next. This article sets forth the high-level steps that should be taken early on ahead of any merger or acquisition event (whether it be assets sale, equity sale, merger, or otherwise) for such businesses to ensure as smooth of a sale as is possible.
Cell surface RNA biology: new roles for RNA binding proteins
References 1. Li, Y. ... An overview on enrichment methods for cell surface proteome profiling J. Sep. Sci. 2020; 43:292-312 2. Bausch-Fluck, D. ... The in silico human surfaceome Proc. Natl. Acad. Sci. U. S. A. 2018; 115:E10988-E10997 3. de Haan, N. ... Sensitive and specific global cell surface -glycoproteomics shows profound differences between glycosylation sites and subcellular components Anal. Chem. 2023; 95:17328-17336 4. Hentze, M.W. ... A brave new world of RNA-binding proteins Nat. Rev. Mol. Cell Biol.
irCLIP-RNP and Re-CLIP reveal patterns of dynamic protein assemblies on RNA - Nature
Abstract RNA-binding proteins (RBPs) control varied processes, including RNA splicing, stability, transport and translation1,2,3. Dysfunctional RNA–RBP interactions contribute to the pathogenesis of human disease1,4,5; however, characterizing the nature and dynamics of multiprotein assemblies on RNA has been challenging.
RNA-binding proteins and glycoRNAs form domains on the cell surface for cell-penetrating peptide entry
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Keywords RNA-binding proteins glycoRNA cell surface cell-penetrating peptides Get full text access Log in, subscribe or purchase for full access. References 1. Varki, A. ∙ Cummings, R.D. ∙ Esko, J.D. ... ... Essentials of Glycobiology Cold Spring Harbor Laboratory Press, 2022 2. Flynn, R.A. ∙ Pedram, K. ∙ Malaker, S.A. ... Small RNAs are modified with N-glycans and displayed on the surface of living cells Cell. 2021; 184:3109-3124.e22 3. Xie, Y. ∙ Chai, P. ∙ Till, N.A. ...
By Jonathan Perr, Andreas Langen, Karim Almahayni, Gianluca Nestola, Peiyuan Chai, Charlotta G. Lebedenko, Regan F. Volk, Diego Detrés, Reese Caldwell, Helena Hemberger, Namita Bisaria, Francisco J. Sanchez-Rivera, Konstantinos Tzelepis, Eliezer Calo, Leonhard Möckl, Balyn W. Zaro, Ryan Flynn, Malte Spiekermann, Toshihiko Aiba
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Cell Press
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A look at Jimmy Carter's life — from Iran to facing cancer Original
Jimmy Carter has died at the age of 100, making him the nation's longest-lived former president. Born in Plains, Georgia, Carter served as the 39th president of the United States and was awarded the 2002 Nobel Peace Prize. Jimmy Carter has died at the age of 100, making him the nation's longest-lived former president. Born in Plains, Georgia, Carter served as the 39th president of the United States and was awarded the 2002 Nobel Peace Prize.
Cell surface ribonucleoproteins cluster with heparan sulfate to regulate growth factor signaling
Abstract Receptor-ligand interactions govern a wide array of biological pathways, facilitating a cell's ability to interrogate and integrate information from the extracellular space. Here, using an unbiased genome-wide knockout screen, we identify heparan sulfate proteoglycans (HSPGs) as a major component in the organizational mechanism of cell surface glycoRNA and cell surface RNA binding proteins (csRBPs).
Compare: Physical Gold vs. Digital Gold - Which Is Best
Bitcoin and gold derive their value from their scarce monetary properties, but the value of Bitcoin is derived from its cryptographic technology, decentralization, and usability as digital gold. This article takes a comprehensive look at how these two forms of “gold” compare regarding value, accessibility, security, liquidity, and other key factors. Bitcoin is commonly referred to as digital gold by many industry experts.
From Vectors to Velocity: Unlocking Acceleration and Collision in Game Worlds!
Hey fellow game dev enthusiasts, Ryan here again! After delving into the world of vectors and their pivotal role in character movement in my last blog, today we’re going to elevate our game with the introduction of acceleration and collision detection. This is where our simple vector concepts start interacting with the real-world principles of physics, adding a whole new layer of realism to our games. First up, let’s talk acceleration.
Vector Magic in Game Development!
Hey there, game dev adventurers! It’s Ryan again, exploring the fascinating world of math in game development. Today, we’re embarking on a journey to understand how vectors breathe life into character movement. Let’s talk about vectors. Think about the classic game ‘Asteroids’. Remember how the spaceship glided across the screen? That’s vectors at work — guiding direction and speed in a seamless dance. In game development, we simplify vectors to X and Y coordinates.
NBA Leather Tour Concert Review
On a snowy night in Chicago, three rappers came together to perform at the Riviera Theatre. The NBA Leather Tour included Boldy James, Earl Sweatshirt, and Action Bronson, along with the producer The Alchemist. These rappers all come from very different backgrounds and levels of success, with their biggest commonality is extensively working with The Alchemist, all of them having multiple songs or even multiple albums with him.
Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing
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Imaging glycosylated RNAs at the subcellular scale - Nature Biotechnology
A recently discovered RNA species on the cell surface is studied by proximity ligation. Why is RNA displayed on the surface of mammalian cells? Although there have been many reported examples of extracellular RNA1, the existence of RNAs residing on the cell surface is just beginning to be appreciated, and little is known about their biological roles.
New Private Fund Adviser Regulations from the SEC
The Securities and Exchange Commission announced on August 23, 2023 that they have adopted new rules under the Investment Advisers Act of 1940 which call for greater transparency for investors who invest in private funds. While some of these rules will make investing with registered investment advisers clearer, others will make the world of venture capital a bit more challenging. A slightly stricter version of the adopted rules was originally proposed by the SEC on February 9, 2022.
Bill Pascrell: Taking Wisdom Learned at Fordham and Putting it to Use
A member of the tax-writing U.S. House of Representatives Ways and Means Committee, Rep. Bill Pascrell (D-N.J.), FCRH ’59, said he is not slowing down at all. “I may be up there in years, but I still have a fight left in me,” he said from his office in the Rayburn House Office Building on Capitol Hill in Washington, D.C. Pascrell has represented New Jersey’s 9th Congressional District for 26 years.
Rare Reg A+ Fines Reflect New Era Of SEC Enforcement
By Ryan Flynn, Matthew Moisan and William Bruno (August 17, 2023, 3:31 PM EDT) -- The U.S. Securities and Exchange Commission announced on May 16 that 10 microcap companies violated Regulation A+ and have been ordered to pay civil penalties ranging from $5,000 to $90,000.... A Law360 subscription puts you at the center of fast-moving legal issues, trends and developments so you can act with speed and confidence.
Ozempic explained: how a miracle diabetes drug became the center of a weight loss craze
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How a Record Number of Anti-LGBTQ Bills Are Spreading in the US
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Slack Ruling May Create Risks for Direct Listings and Investors
In its long-awaited decision in Slack Technologies, LLC v. Pirani, 598 U.S. ___, No. 20-200 (June 1, 2023), the Supreme Court ruled that the tracing requirement of Section 11 of the Securities Act of 1933 applies to suits brought by investors in direct listings. Although the ruling definitively resolves an ambiguity in the statutory text, it leaves the door open to adverse consequences for both companies and investors in direct listings.
Inside Putin's Secret Bunker and Billion-Dollar Palace
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How wind turbine technicians keep blades spinning from 360 feet in the air
Wind turbine technicians dangle from heights of up to 360 feet to work on wind turbines. João Sardo has been working as a wind turbine specialist for nearly 20 years. Renewable energy is booming in Europe as the Russia-Ukraine war has put a squeeze on energy. In Portugal, wind turbine technicians get paid nearly double the average salary. It is a highly specialized position, and technicians must hang from turbines the size of 35-story skyscrapers to make repairs and do inspections.
Why the Pentagon Leak Is Embarrassing for the US Government
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Why Sandstorms Are Hitting Parts of China
Chevron icon It indicates an expandable section or menu, or sometimes previous / next navigation options. HOMEPAGE 0 Subscribe Save Article Icon A bookmark Facebook Icon The letter F. Read in app Sandstorms caused thick orange clouds to blanket Beijing, China. The city gets these storms because it's close to the Gobi Desert. Pollution levels rose dangerously high as dust particles filled the air. Loading Something is loading.
China shows how it would attack Taiwan as tensions rise
These are the 15 worst places to buy a home if you want it to increase in value. Almost all of them are in the Midwest.
China Shows How It Would Attack Taiwan As Tensions Rise
Chevron icon It indicates an expandable section or menu, or sometimes previous / next navigation options. HOMEPAGE 0 Subscribe Save Article Icon A bookmark Facebook Icon The letter F. Read in app China's military conducted three days of military drills near Taiwan. The drills blocked off the island with fighter jets and war ships. It was a response to Taiwan President Tsai Ing-wen's meeting with House Speaker Kevin McCarthy. Loading Something is loading.
The Power of Human Critical Thinking and Problem...
In recent years, the rapid advancements in artificial intelligence (AI) have sparked concerns over the potential displacement of human workers, including software engineers. While AI has made significant strides in automating certain tasks and processes, it is essential to remember that the value of human critical thinking and problem-solving skills cannot be easily replaced.
Tin mining is big business in Indonesia. Here's why miners risk their lives for $13 a day. Original
Small crews spend long hours on these makeshift pontoons sifting through sand to find tin, which is used in phones, food cans, cosmetics, paints, and fuel. Makeshift pontoons for an illegal tin mine in the Indonesian sea. Ibnu Hadi Rachmat Joko Tingkir, a tin miner, dives 65 feet underwater three or four times a day. An injury caused by diving makes him walk with a limp. Joko Tingkir walks from the beach to his mining pontoon to start his work day.
Colombia Seizes 5,800 Pounds of Cocaine From a Submarine Original
The Colombian Navy seized a submarine with 5,800 pounds of cocaine on board. Authorities also found two dead bodies in the submarine and two survivors in poor health. The seized cocaine was valued at $87 million. Colombian authorities seized a submarine in the Pacific Ocean, finding 5,800 pounds of cocaine on board. They also found two dead bodies and two survivors in poor health. The submarine was on its way to Central America.
Why Silicon Valley Bank Collapsed, and Why It Matters
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An Inside Look at El Salvador's New 'Megaprison'
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The war in Ukraine by the numbers, one year later
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The War in Ukraine by the Numbers, One Year Later Original
The war in Ukraine entered its second year on February 24, 2023. At least 7,000 Ukrainian civilians have died since Russia invaded Ukraine. President Volodymyr Zelenskyy said he thinks Ukraine will win. The war in Ukraine entered its second year on February 24, 2023. At least 7,000 Ukrainian civilians have died since Russia invaded Ukraine.
Vital Javascript skills that you should know!
As a web developer, it's important to stay up-to-date with the latest developments in the industry, and to have a deep understanding of the core concepts that underpin JavaScript. We're going to run through some topics that will give you valuable insights and practical knowledge that you can apply on your web development journey. Equality is a concept in JavaScript that deals with comparing values to check if they are equal.
Rescuers pull out survivors one week after earthquake in Turkey and Syria
Rescuers continue to save victims from under collapsed buildings in Turkey and Syria. At least 36,000 people have died, and 90,000 have been injured, in the earthquake. Humanitarian efforts are shifting focus away from rescues. Rescuers pulled out at least seven survivors one week after a 7.8 magnitude earthquake hit Turkey and Syria. As fewer survivors are being found, humanitarian efforts shift to providing aid to the survivors.
French Citizens Rebel As Macron Tries to Raise Pension Age
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Why People Risk Their Lives to Make Millions of Bangles in India
Chevron icon It indicates an expandable section or menu, or sometimes previous / next navigation options. HOMEPAGE 0 Newsletters Subscribe Save Article Icon A bookmark Facebook Icon The letter F. Download the app Amar Gurung & Priyanka Mukherjee Glass bangles are popular accessories for millions of women in India. Making them exposes workers to scorching hot furnaces, broken glass, and dangerous fumes — all for less than $10 a day.
Why people risk their lives to make millions of bangles in India
1 day ago DUBAI, United Arab Emirates (AP) — Iran has enough highly enriched uranium to build “several” nuclear weapons if it chooses, the United Nations’ top nuclear official is now warning. But diplomatic efforts aimed at again limiting its atomic program seem more unlikely than ever before as Tehran arms …
Why people risk their lives to make millions of bangles in India
17 hours ago From the Andamans to Zanzibar. It doesn’t matter if you’re planning ahead for a classic summer getaway or want to swap hemispheres to escape your winter blues: The best Island vacations in the world await. Those OOO messages pretty much write themselves when you arrive at your slice of paradise, …
Developing your business acumen as a product manager
Marketing is the process of promoting a product or service to potential customers. This includes developing marketing plans, identifying target markets, and creating advertising and promotional materials. Product managers need to be familiar with different marketing techniques, such as digital marketing, content marketing, and influencer marketing, in order to effectively promote their products and reach their target audience.
What We Know About the Biden Classified Documents Drama
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