Sabine Heitzeneder

ArticleVolume 7, Issue 1102549Open access 1Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA, USA 2Department I of Internal Medicine, Center for Integrated Oncology Aachen Bonn Cologne Duesseldorf, University of Cologne, Medical Faculty and University Hospital Cologne, Cologne, Germany 3Cancer Center Cologne Essen (CCCE), Cologne, Germany 4Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany 5University of Cologne,...

Highlights • GPC2-CARs with standard 41BB designs require >3 × 104 molecules for full activation • Metastatic neuroblastomas express ∼5 × 103 GPC2 molecules/cell • CAR antigen density threshold is highly tunable using modular engineering and c-Jun overexpression • Tuned GPC2 CAR T cells mediate potent neuroblastoma regression without toxicity Summary Pediatric cancers often mimic fetal tissues and express proteins normally silenced postnatally that could serve as immune targets.

Poster Presentations - Proffered Abstracts Sabine Heitzeneder, Kristopher R. Bosse, Zhongyu Zhu, Robbie G. Majzner, Johanna Theruvath, Peng Xu, Shaurya Dhingra, Hima Anbunathan, Anya Alag, Dimiter S. Dimitrov, John M. Maris and Crystal L.