Sam Golden

Keywords opioids withdrawal addiction septum behavior neurocircuits neurotensin cell type optogenetics sequencing Get full text access Log in, subscribe or purchase for full access. References 1. Koob, G.F. ∙ Le Moal, M. Drug Addiction, Dysregulation of Reward, and Allostasis Neuropsychopharmacology. 2001; 24:97-129 2. George, O. ∙ Koob, G.F. Individual differences in the neuropsychopathology of addiction Dial. Clin. Neurosci. 2017; 19:217-229 3. Welsch, L. ∙ Bailly, J. ∙ Darcq, E. ...

Abstract As the primary source of noradrenaline in the brain, the locus coeruleus (LC) regulates arousal, avoidance and stress responses1,2. However, how local neuromodulatory inputs control LC function remains unresolved.

Neuroscience is approaching a critical juncture, transitioning from subjective behavioral observation to objective behavioral definition. This is now possible due to analytical tools using machine-guided solutions for animal markerless key-point pose tracking (see Table 1 for specialized terminology definitions) and behavioral detection. However, it is often challenging for behaviorists to adopt these approaches due to a lack of specialized computational knowledge.