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Kelsey Barcomb on Muck Rack

Kelsey Barcomb

As seen in: Color Research & Application, Nature, BioRxiv, Cell Press, The Journal of Biological Chemistry
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Articles

Heterogeneous pericoerulear neurons tune arousal and exploratory behaviours - Nature

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By Madison Martin, Kelsey Barcomb, Sarah Thai, Sam Golden, Garret D. Stuber, Liangcai Gu
| Nature Verified
Abstract As the primary source of noradrenaline in the brain, the locus coeruleus (LC) regulates arousal, avoidance and stress responses1,2. However, how local neuromodulatory inputs control LC function remains unresolved.
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Overexpression of alpha synuclein in Midbrain Dopamine Neurons Reduces Dopamine Release Without Cell Loss and Drives Mild Motor Deficits in Mice

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By Kelsey Barcomb, Julia Lemak, Xiaowen Zhuang, Jen-Tsiang Hsiao
| BioRxiv
Abstract It has proven challenging to faithfully recapitulate the key pathological, physiological, and behavioral features of Parkinson Disease (PD) in animals. Here we used adeno-associated virus (AAV) vectors to achieve cell type-specific overexpression of wild-type human α-synuclein (αsyn) and a fluorophore (mCherry) in midbrain dopamine neurons to model PD in mice. We found that AAVs drove selective expression of both αsyn and mCherry in midbrain dopamine neurons.
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A diverse population of pericoerulear neurons controls arousal and exploratory behaviors

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By Andrew T Luskin, Xiaonan Fu, Madison Martin, Kelsey Barcomb
| BioRxiv
Abstract As the primary source of norepinephrine (NE) in the brain, the locus coeruleus (LC) regulates arousal, avoidance and stress responses. However, how local neuromodulatory inputs control LC function remains unresolved. Here we identify a population of transcriptionally, spatially and functionally diverse GABAergic neurons in the LC dendritic field that receive distant inputs and modulate modes of LC firing to control global arousal levels and arousal-related processing and behaviors.
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